急性脑梗死患者CD4+、CD8+-T淋巴细胞和肿瘤坏死因子-α变化的研究

目的:探讨脑梗死患者外周血CD4 、CD8 -T淋巴细胞亚群和血清肿瘤坏死因子-α(TNF-α)在脑梗死发病中的作用及两者的相关关系。方法:运用流式细胞仪及酶联免疫检测仪,对45例急性脑梗死患者(观察组)和30名健康体检者(对照组)外周血CD4 、CD8 -T淋巴细胞百分率和血清中TNF-α浓度进行检测,并分析两者的相关性。结果:急性脑梗死患者外周血中CD8 -T淋巴细胞和血清中TNF-α浓度均比对照组显著增加,CD4 -T淋巴细胞及CD4 /CD8 明显减低,且随病情加重而显著改变。结论:急性脑梗死时,患者外周血中CD4 、CD8 -T淋巴细胞和血清中TNF-α浓度异常改变,参与了急性脑梗死的异常病情反应,在脑梗死发病中起重要作用。     

DL-α-丙氨酸合成工艺的新进展及其应用

介绍了国内外目前制备DL－α－丙氨酸的几种工艺，并提出了多元溶剂循环合成和反馈式离子膜法分离DL－α－丙氨酸的生产新工艺。该工艺避免了使用大量有毒溶剂－甲醇，降低能耗50％以上，减少了设备投资，提高了产品质量，并能回收氯化铵副产物，显著降低了原料成本，基本消除了三废。同时介绍了DL－α－丙氨酸的应用。     

硫磺矿硫化叶菌耐酸α-淀粉酶基因的克隆及其在枯草芽孢杆菌中的表达

以硫磺矿硫化叶菌基因组DNA为模板进行PCR扩增,得到其淀粉酶基因.将该片段与载体pSBPYF连接后转化枯草芽孢杆菌DB1342,得到重组菌株DB1342(pSBA),对该菌株进行培养,经蔗糖诱导表达,在其上清中可检测到α-淀粉酶活力,比空载体的淀粉酶活力高了3倍多.该酶作用的最适pH值为4.3,最适作用温度为80℃,在酶液中添加不同的金属离子均降低酶活.     

＜α,T＞凸函数初探

首先定义了一类新的凸函数:＜α,T＞凸函数,它是通常的中点凸函数的一般形式,并推出了＜α,T＞凸函数的一系列不等式,它们是凸函数中某些相应的著名不等式的推广.     

α—硫羧基硫代甲酰胺与丁炔二酸二乙酯的反应探索

本文研究了α－硫代苯甲酰基硫代甲酰吗啉与丁炔二酸二乙酯的反应。结果表明生成的产物为取代噻吩。     

慢性幽门螺旋杆菌感染、血清TNF-α变化与脑梗死相关研究

目的:检测血清中TNF-α含量的变化,用以研究慢性幽门螺旋杆菌(Helicobacter pylori,Hp)感染与脑梗死的关系。方法:采用病例对照的研究方法,选择急性脑梗死患者65例为病例组,健康体检者50例为对照组。用13C-尿素呼气实验检测Hp感染,用酶联免疫吸附法定量检测血清中TNF-α的含量。结果:①病例组与对照组的Hp阳性率分别是32.3%和14.0%,病例组明显高于对照组,两组比较有统计学意义;②28例Hp阳性者血清中TNF-α的含量平均值20.08±8.82pg/ml。87例Hp阴性者是15.07±5.30pg/ml,Hp阳性组明显高于Hp阴性组,两组比较有统计学意义。结论:慢性Hp感染是急性脑梗死的一个危险因素,慢性Hp感染可引起血清中TNF-α的含量增高,后者是导致急性脑梗死的发病机制之一。     

Projectively flat exponential Finsler metric

INTRODUCTION One century ago, Hilbert announced his famous 23 problems. The Hilbert’s Fourth Problem is to characterize the (not-necessarily-reversible) distance functions on an open subset in ún such that straight lines are shortest paths. Distance functions induced by a Finsler metric are regarded as smooth ones. Thus Hilbert’s Fourth Problem in the smooth case is to characterize Finsler metric on an open subset in ún whose geodesics are straight lines. Finsler metric on an ope…     

Basic fibroblast growth factor alleviates brain injury following global ischemia reperfusion in rabbits

The aim of this study was to explore the protective effect of basic fibroblast growth factor (bFGF) on brain injury following global ischemia reperfusion and its mechanisms. Brain injury following global ischemia was induced by four vessels occlusion and systemic hypotension. Twenty-four rabbits were randomized into three groups: group A, only dissection of vessels; group B, intravenous infusion of normal saline after reperfusion for 6 h; group C, 30 μg/kg bFGF injected intravenously at the onset of reperfusion, then infused with 10 μg/(kg·h) for 6 h. Serum neuron specific enolase (NSE), S-100B, tumor necrosis factor-α(TNF-α), interleukin-1 (IL-1), interleukin-8 (IL-8) were measured before ischemia, 30 min after ischemia, 0.5, 1, 3, 6 h after reperfusion. Brain water content was determined and cerebral histopathological damages were compared. NSE and S-100B were increased 1 h after reperfusion and reached their peaks 6 h after reperfusion, but were much higher in group B than those in group C 3, 6 h after reperfusion. In groups B and C, TNF-a was increased after ischemia and IL-1 and IL-8 were increased significantly 0.5 h after reperfusion, then reached their peaks 6 h, 3 h, 6 h after reperfusion respectively. TNF-a and IL-8 at the time points of 1 h and 3 h and IL-1 at 3 h and 6 h in group C were correspondingly lower than those in group B. These indices in group A were nearly unchanged. There were less severe cerebral histopathological damages in group C compared with group B, but no difference in brain water content. It could be concluded that bFGF alleviates brain injury following global ischemia and reperfusion by down-regulating expression of inflammatory factors and inhibiting their activities.     

修正α—亏量及满亏量问题

本文讨论超亚纯函数的修正α-亏量,得到亏量关系:并解决了一个满亏量问题:若则f(z)的级是整数。