我国水污染的防治及其相关问题的思考

水资源是基础自然资源,同时又是战略性经济资源,为综合国力的有机组成部分,水资源已经成为我国社会经济发展的短缺资源,成为制约我国全面建设小康社会的瓶颈之一,加大水污染防治工作力度刻不容缓;针对我国水质污染状况严重、污水排放量逐年增加的现状,提出了水污染防治的相关措施;强调实施污水资源化战略应作为水资源供需矛盾的主要手段。     

海州露天矿矿山地质灾害成因及主要治理措施探讨

介绍了海州露天矿已发生及潜在的地质灾害状况,通过分析地质灾害的成因和特征,进一步探讨对地质灾害应采取的有效治理措施。     

对1927——1937年南京国民政府发行公债的再认识——以统一公债为核心

抗战前十年,南京国民政府发行了巨额的国内公债。它是中国当时社会政治、经济的产物和统治阶级进行阶级统治的需要。这些公债的发行使国民政府的工业、国防基础设施的建设成为可能。为中国坚持抗战并最终取得胜利打下了物资基础。其历史作用是应该得到肯定的。     

抗战前期上海对南洋的贸易研究

从八一三战事结束到太平洋战争爆发之前，上海与南洋各地的贸易获得了前所未有的发展，并且呈现出了贸易地位提高、华商经营比重上升、转口贸易大量存在、贸易结构变动、贸易统制强化等一系列与战前不同的特点。这种贸易不仅维持了上海对外贸易的盛况，有利于上海和南洋各地的民生需要和经济发展，而且对大后方的军需民用也有一定的积极意义。     

长征对敌我心理的影响分析

长征不仅具有非凡的军事和政治意义,在由国内战争向民族战争转变之际,对社会各阶级的心理影响也是巨大的,它增强了共产党人的胜利自信心和革命使命感,提高了社会号召力,赢得民众信任,也滋长了国民党内部对“剿共”战争的抵触情绪。     

用单片机I/O引脚实现A/D功能的原理与应用

本文利用现行有些单片机输入，输出(I／O)引脚的输入阻抗高、输出驱动能力强的特性，分析了用I／O引脚实现模数转移的原理，并在此基础上，提出了这种方法在电阻测量、键盘检测中的应用。通过该方法的讨论可开阔解决问题的思路。     

抗战时期陈垣先生的史学成就

抗战期间，陈垣先生撰写了《明季滇黔佛教考》等宗教史作和最能代表他学术成就的史注研究专《通鉴胡注表微》，贡献出一批精审的史学研究成果。他的研究在考证方法和材料运用诸方面有新的突破，同时由于倡导有意义的史学，将史考与史义紧密结合起来，努力发挥史学的社会功能，使他的学术研究进入了一个新的境界。     

中华民族的英勇抗战与中国共产党的领导能力--纪念抗日战争胜利60周年

抗日战争胜利的决定性因素为全民族的英勇抗战和共产党领导成为中流砥柱，其领导能力得到充分实现、迅速拓展和根本性升华。全民族的英勇抗战为历史悲壮性与现实残酷性所使然，亦是党有效的政治动员与组织的结果；党的领导能力的充分实现与升华，既是党的先进性的逻辑体现，又是党的革命性在伟大斗争生成的结果，源于全民族的伟大抗日斗争，又指导全民的抗日斗争。     

Dynamic resistance exercise increases skeletal muscle-derived FSTL1 inducing cardiac angiogenesis via DIP2A–Smad2/3 in rats following myocardial infarction

PurposeThe aim of this study was to investigate the potential of dynamic resistance exercise to generate skeletal muscle-derived follistatin like-1 (FSTL1), which may induce cardioprotection in rats following myocardial infarction (MI) by inducing angiogenesis.MethodsMale, adult Sprague-Dawley rats were randomly divided into 5 groups (n = 12 in each group): sham group (S), sedentary MI group (MI), MI + resistance exercise group (MR), MI + adeno-associated virus (AAV)–FSTL1 injection group (MA), and MI + AAV–FSTL1 injection + resistance exercise group (MAR). The AAV–FSTL1 vector was prepared by molecular biology methods and injected into the anterior tibialis muscle. The MI model was established by ligation of the left anterior descending coronary artery. Rats in the MR and MAR groups underwent 4 weeks of dynamic resistance exercise training using a weighted climbing-up ladder. Heart function was evaluated by hemodynamic measures. Collagen volume fraction of myocardium was observed and analyzed by Masson''s staining. Human umbilical vein vessel endothelial cells culture and recombinant human FSTL1 protein or transforming growth factor-β receptor 1 (TGFβR1) inhibitor treatment were used to elucidate the molecular signaling mechanism of FSTL1. Angiogenesis, cell proliferation, and disco interacting protein 2 homolog A (DIP2A) location were observed by immunofluorescence staining. The expression of FSTL1, DIP2A, and the activation of signaling pathways were detected by Western blotting. Angiogenesis of endothelial cells was observed by tubule experiment. One-way analysis of variance and Student''s t test were used for statistical analysis.ResultsResistance exercise stimulated the secretion of skeletal muscle FSTL1, which promoted myocardial angiogenesis, inhibited pathological remodeling, and protected cardiac function in MI rats. Exercise facilitated skeletal muscle FSTL1 to play a role in protecting the heart. Exogenous FSTL1 promoted the human umbilical vein vessel endothelial cells proliferation and up-regulated the expression of DIP2A, while TGFβR1 inhibitor intervention down-regulated the phosphorylation level of Smad2/3 and the expression of vascular endothelial growth factor-A, which was not conducive to angiogenesis. FSTL1 bound to the receptor, DIP2A, to regulate angiogenesis mainly through the Smad2/3 signaling pathway. FSTL1–DIP2A directly activated Smad2/3 and was not affected by TGFβR1.ConclusionDynamic resistance exercise stimulates the expression of skeletal muscle-derived FSTL1, which could supplement the insufficiency of cardiac FSTL1 and promote cardiac rehabilitation through the DIP2A–Smad2/3 signaling pathway in MI rats.