游泳训练对Ⅱ型糖尿病Wistar大鼠肠系膜动脉舒张功能改善作用的研究

目的:通过建立wistar大鼠Ⅱ型糖尿病动物模型,观察Ⅱ型糖尿病(T2DM)模型大鼠,经游泳训练后肠系膜动脉舒张功能的变化,并探讨其内在影响机制。方法:实验材料wistar大鼠60只,造模完成后随机分成3组:正常对照组(CON),Diabetes模型组(DI),游泳运动组(SEX),每组15只。进行游泳训练共计8周。结果:T2DM可造成肠系膜动脉血管舒张功能降低(P<0.05),且存在内皮依赖性。舒张功能的降低与eNOS-NO系统活性降低直接相关。游泳训练可有效维持内皮依赖性舒张功能(P<0.05),其上调eNOS-NO系统。另外,T2DM造成的eNOS-NO系统活性降低与该系统上游蛋白PI-3K,Akt降低有关,且在加入上游蛋白抑制剂(PI-3K)LY294002及eNOS阻断剂L-NAME后保护效应消失。结论:游泳训练能改善T2DM wistar大鼠肠系膜舒动脉舒张功。其内在保护作用可能是通过部分激活PI-3K-Akt-eNOS信号通路而实现。     

运动训练对自发性高血压大鼠心肌细胞凋亡蛋白表达的影响

目的:研究运动训练对SHR心肌细胞中HSP-72、Bcl-2和蛋白激酶β(PKB)、Bax、糖原合成激酶-3(GSK-3)的影响,以探讨其对运动引起心肌细胞凋亡的作用。方法:以SHR大鼠中等强度训练为实验模型,采用Western bloting技术检测了大鼠心肌细胞中调控蛋白HSP-72、Bcl-2和蛋白激酶β(PKB)、Bax、糖原合成激酶-3(GSK-3)的表达。结果:长期中等强度训练可以提高心肌细胞中抑凋亡蛋白HSP-72、Bcl-2和蛋白激酶β(PKB)的表达,凋亡蛋白Bax、糖原合成激酶-3(GSK-3)表达显著降低,Bcl-2/Bax的表达没有显著变化,从而抑制心肌细胞的凋亡。结论:心肌细胞中HSP-72、Bcl-2和蛋白激酶β(PKB)、Bax、糖原合成激酶-3(GSK-3),Bcl-2/Bax在运动后的不同表达对心肌细胞凋亡的发生有明显的抑制作用。     

TGMD-3在中国3~12岁儿童基本运动技能测试中的信效度研究

目的: 验证TGMD-3在中国3~12岁儿童基本运动技能测试中的可靠性和有效性。方法: 选取上海、深圳、重庆、洛阳、长沙的512名3~12岁儿童为研究对象进行TGMD-3测试,对测试的难度、区分度、一致性信度、重测信度和评价者信度、结构效度进行统计检验。结果: TGMD-3的13个项目难度范围为0.27~0.78,区分度范围为0.38~0.49。每个年龄组儿童基本运动技能测试(TGMD-3)的内部一致性系数范围为0.808~0.902,其中男女生的内部一致性系数均为0.95;总体的基本运动技能评价者信度(肯德尔协同系数)w为0.944, 2值为28.331,达到显著性水平;重测检验中,移动式运动技能(组内相关系数)ICC为0.755、球类运动技能(组内相关系数)ICC为0.741、总的基本运动技能(组内相关系数)ICC为0.743,均达到了较高水平。通过探索性因子分析验证了TGMD-3的双因子结构,并通过验证性因子分析支持双因子模型(χ²(64)=103.28,p<0.001,CFI=0.960,TLI=0.952,RMSEA=0.049,SRMR=0.043)。结论: TGMD-3儿童基本运动技能测试具有良好的项目难度、区分度,以及可靠的内部一致性信度、重测信度和结构效度,对我国3~12岁儿童具有良好的适用性,可以作为我国儿童基本运动技能发展评价的有效工具。     

3G时代的手机媒体与未来的期刊出版

从3G时代手机媒体的特点出发,分析其对读者的阅读行为与习惯的影响,提出了3G时代期刊界应彻底转变观念,处理好纸介质出版与数字出版、一般的数字出版与手机媒体数字出版的关系,开展传统出版与手机传媒间的整合,实现资源共享;建设各个类型的数据库,培育发展手机媒体的数字内容业务;创新商业模式,向特定读者提供个性化服务;加强内容资源的建设,提升期刊市场竞争力：为未来的期刊出版提供了新的思路。     

决策树挖掘算法在教评体系中的应用研究

对高校教学质量评估体系中学生的大量评教数据和教师的档案数据进行数据挖掘,重点研究决策树方法中的ID3算法在教学质量评估体系中的应用。利用决策树挖掘算法挖掘影响教学质量的关键因素,找出数据的内在规律,并对挖掘结果进行分析,从中提取有用信息,才能更好地为管理决策分析提供科学依据。     

Automatic generation method of geological cross-sections in dredging engineering based on 3D solid NURBS models

An automatic generation method of geological cross-sections in dredging engineering based on 3D geological solid models is presented.The 3D geological models are built applying the non-uniform rational B-splines(NURBS) technique,and a 2D profile can be calculated and generated automatically through Boolean operation to meet the demands of dredging projects.Moreover,an automatic marking method for geological attributes is put forward based on database technology,and the geological attributes include the profile name,scale,horizontal and vertical relative coordinates,geological lithology,and 2D standard lithology legend.At the same time,the automatic marking method can also provide an interactive mode for geological engineers to edit and modify the profile in the modeling system.Practical engineering applications show that the automatic generation method is a simple,flexible,fast and precise visual graphics rendering process that can create 2D standard profiles automatically and efficiently.This method also provides a convenient support tool for geological engineering digital analysis.     

A tale of two literatures: Transaction costs and property rights in innovation outsourcing

This paper investigates the relative importance of property rights and transactions cost factors in driving the decision of firms to outsource innovation. Using data for over 8000 firms from the UK Community Innovation Survey, we find that property right factors dominate over transaction cost factors. Transaction cost variables are more important for process innovation, while property rights variables are more significant for firms involved in product innovation. In addition, we find that firms involved in process innovation have a higher probability of outsourcing innovation than firms involved in product innovation.     

Openness and innovation—Home and export demand effects on manufacturing innovation: Panel data evidence for Ireland and Switzerland

Recent studies in the tradition of Schmookler have re-emphasised the potential role of demand in stimulating innovation. Here, we reconsider the role of ‘home’ and ‘export’ market demand in stimulating manufacturing innovation using comparable panel data for two small open economies - Ireland and Switzerland. Our analysis is based on the estimation of reduced form innovation production functions using panel data estimators over the sample period 1994-2005. For a range of innovation indicators, however, we find little evidence of any significant market demand effects, with innovation performance instead determined largely by firm-level capability effects and characteristics. In policy and strategy terms this suggests the continued value of measures to improve innovation capability regardless of market demand conditions. In more methodological terms our results suggest the validity of the usual assumption implicit in modelling innovation outputs that supply-side factors predominate.     

比格斯教学理论述评

爱现代科技发展的影响，教学开始有追求效率化、精确化和客观化的趋势，并把它们作为科学化的标准。这种功利主义、实证主义的教学具有工具化的倾向，容易使教学与生活相脱离。澳大利亚教学论学者比格斯在批评这种学习理论和教学理论的同时，提出了自己的学习理论和教学理论。     

基于HTML5+CSS3交互式网页布局的研究

本文主要阐述最热门交互式网页布局技术HTML+CSS的发展历程,以及HTML5+CSS3的优势,并以HTML5中新的页面交互元素应用为例讲述其新的交互功能,并通过CSS3样式表的控制功能完善交互式网页的布局的案例体现HTML5与CSS3相结合在制作交互式网页中起到的关键性作用。