简论书目著录标准RDA和AACR2的异同

论文先后论述了RDA的定义、RDA和AACR2的主要异同、RDA的重要性、RDA的目标与原则,最后通过与AACR2比较,归纳了RDA的五个基本特点.     

Struts2框架浅析

Struts2作为当今优秀的MVC框架,具有功能强大、使用简单灵活的优点,本文对Struts2的产生背景、运作机制、Struts2框架的搭建等进行了介绍,较全面展现了Struts2框架,以供Struts2框架学习和开发人员参考。     

江西节能减排与清洁发展机制研究

清洁发展机制是根据《京都议定书》建立的一种创新型国际合作机制,是发达国家和发展中国家的一种国际合作方式,发展清洁发展机制项目既有助于推进实现节能减排目标,也为减缓全球气候变化作出积极贡献。江西具有开展清洁发展机制项目的优势,应充分利用清洁发展机制,实现"十二五"规划节能减排目标。     

互联网金融借贷平台的法律问题研究:以P2P为例

本文主要通过介绍互联网金融P2P借贷发展的概念,详细分析了互联网金融最具代表性的P2P网络借贷平台最近的发展状况及其带来的各种法律风险。然后运用国内外互联网金融理论对我国P2P网络借贷平台的现实问题进行具体阐述,提出一系列完善法律制度、建立完善互联网金融体系的建议。     

基于鱼群的PSO粒子滤波算法

粒子群优化(PSO)粒子滤波算法比较而言,容易陷入局部最优,因此算法的准确度就会降低。本文在解决该问题时引入了一种基于鱼群的PSO粒子滤波算法。此算法是通过鱼群优化在采样过程中找到全局最优的相对位置,使其能够向全局最优的位置逐渐接近,同时提高估计有效的粒子数目,从而能够更有效的减少粒子退化与枯竭问题。实验表明,此算法与PSO粒子滤波算法相比,在估计准确度方面有了较大的提升。     

酸浆宿萼总皂苷对小鼠免疫活性的影响

本文以干燥的酸浆宿萼为实验材料,经乙醇回流提取,并通过溶剂萃取和大孔树脂进一步分离得到酸浆宿萼皂苷(TSP)。以不同剂量TPS连续20天对正常小鼠进行灌胃,探讨了TPS对小鼠免疫活性的作用。结果表明:高剂量(40mg/m L)的TPS溶液能极显著的增加小鼠的免疫器官指数(P0.05)和巨噬细胞吞噬指数;免疫球蛋白(Ig G)含量,P0.01;改善血常规指数。而低剂量(5mg/m L)的TPS溶液对小鼠上述指标有显著的正面影响,P0.05。总体上,在实验浓度范围内,TPS具有增强小鼠免疫活性的作用且呈剂量依赖性。     

Migrating product structure bill of materials Excel files to STEP PDM implementation

It is important for manufacturing companies to provide a standard for product data exchange between diverse computer systems. Past attempts to develop neutral format standards for data exchange have had limited success, and have led to the development of STEP (Standard for the Exchange of Product) as a data exchange standard. The STEP standard makes it easier to integrate systems that process various product life-cycle functions, such as design, engineering, manufacturing, logistics support, and will help to facilitate concurrent engineering. The goal of this paper is to facilitate the computer-readable exchange of the product bill of materials (BOM) information for product data management (PDM). In this paper, the STEP ISO 10303-21 is implemented to share the product data information in a manufacturing environment. A structural product bill of materials is first transformed into an Excel file format, then a PDM Schema Exporter is utilized to export a BOM Excel file to a STEP Part 21 file. A C# program decodes the STEP file into BOM information to update the PDM databases in SQL server for product data management. Also, SAS code is written to generate the indented bill of materials from the BOM information, to draw a tree diagram to present an accurate structural view of a product, and to export to PDM databases for product data structural view.     

Understanding the Internet banking adoption: A unified theory of acceptance and use of technology and perceived risk application

Understanding the main determinants of Internet banking adoption is important for banks and users; our understanding of the role of users’ perceived risk in Internet banking adoption is limited. In response, we develop a conceptual model that combines unified theory of acceptance and use of technology (UTAUT) with perceived risk to explain behaviour intention and usage behaviour of Internet banking. To test the conceptual model we collected data from Portugal (249 valid cases). Our results support some relationships of UTAUT, such as performance expectancy, effort expectancy, and social influence, and also the role of risk as a stronger predictor of intention. To explain usage behaviour of Internet banking the most important factor is behavioural intention to use Internet banking.     

基于区位拉动因素的中国企业OFDI动机的实证研究

近年来,以中国为代表的新兴国家成为推动发展中国家对外直接投资(Outward FDI,OFDI)浪潮的主要来源国。本文首先在资源基础观的基础上构建适合新兴国家跨国公司对外直接投资战略动机的理论框架,将对外直接投资的动机划分为资源强化型、资源补充型和资源开发型三类;接着从东道国区位拉动因素着手构建假设,通过逆向推理的方法探索中国企业OFDI的战略动机。运用面板数据模型,对1998-2008年间中国在53个经济体的OFDI活动进行实证研究。结果表明:中国企业对外直接投资的战略动机主要是资源强化型和资源补充型投资。投资动机随时间和国内政策的影响而发生变化,呈现出依次多元化的特点,并因东道国区位优势的不同而异。本研究不但有利于研究中国企业OFDI的成因,而且为新兴国家对外直接投资战略的一般规律性研究提供参考。     

Delineation of the Structural Elements of Oriental Liver Fluke PLA2 Isoforms for Potent Drug Designing

Clonorchis sinensis or the Chinese liver fluke is one of the most prevalent parasites affecting a major population in the oriental countries. The parasite lacks lipid generating mechanisms but is exposed to fatty acid rich bile in the liver. A secretory phospholipase A₂, an enzyme that breaks down complex lipids, is important for the growth of the parasite. The enzyme is also implicated in the pathogenesis leading up to the hepatic fibrosis and its complications including cancer. The five isoforms of this particular enzyme from the parasite therefore qualify as potential drug targets. In this study, a detailed structural and ligand binding analysis of the isoforms has been done by modeling. The overall three dimensional structures of the isoforms are well conserved with three helices and a β-wing stabilized by four disulfide bonds. There are characteristic differences at the calcium binding loop, hydrophobic channel and the C-terminal domain that can potentially be exploited for drug binding. But the most significant feature pertains to the catalytic site where the isoforms exhibit three variations of either a histidine-aspartate-tyrosine or histidine-glutamate-tyrosine or histidine-aspartate-phenylalanine. Molecular docking studies show that isoform specific residues and their conformations in the substrate binding hydrophobic channel make unique interactions with certain inhibitor molecules resulting in a perfect tight fit. The proposed ligand molecules have a predicted affinity in micro-molar to nano-molar range. Interestingly, few of the ligand binding interaction patterns is in accordance to the phylogenetic studies to thereby establish the usefulness of evolutionary mechanisms in aiding ligand design. The molecular diversity of the parasitic PLA₂ described in this study provides a platform for personalized medicine in the therapeutics of clonorchiasis.

Electronic supplementary material

The online version of this article (doi:10.1007/s12291-013-0377-1) contains supplementary material, which is available to authorized users.