对事业部体制下企业核心能力管理问题的探讨

事业部制自产生以来就日益在产业界得到了广泛的应用，并成为企业组织结构的标准模式之一。然而欧美、日本等国家的一些大企业在其事业部制实践中逐渐认识到传统事业部制在核心能力管理上存在着一定的缺陷，并通过一些探索性的实践对事业部制的修正与发展进行了努力。本文对事业部制下企业核心能力管理问题进行了进一步的分析和探讨，以期为我国事业部体制的发展和完善提供借鉴与参考。     

我国“十四五”时期高质量发展的国土空间治理与区域经济布局

"十四五"时期,空间治理现代化和区域经济布局优化是规划和发展的重要内容。改革开放以来,我国区域经济布局采用"部分地区先富起来"的指导思想,迅速带动了国力整体提升,但区域间发展差距持续拉大;开放经济与非国有经济发展迅猛,但经济体系安全性和高级化存在"短板",国有经济领域改革尚有不足。我国空间治理进步显著,但在法制化和科学化、学习型政府和民主化治理及治理体系化等方面,同现代化要求差距较大。"十四五"时期,空间治理现代化的重点是:完善政府、市场、社会组织、公众共同参与的空间治理模式,健全公平与效益并重、政府调控与市场优化配置并重、问题与目标并重、约束与激励并重的区域政策体系,形成适应高质量发展要求的区域协调新机制。区域经济布局的重大举措是:不断增强城市群、都市圈和区域中心城市的能级,践行人口经济集聚过程中实现区域均衡协调发展的新模式。以重构我国相对完整的产业体系为契机,打造重大生产力布局的新形态。启动大西北地区高质量开发的伟大工程,培育相对贫困地区发展致富的新动力。     

“十四五”时期行政区划设置与空间治理的探讨

行政区划一直都是国家进行地方治理的基础支撑单元。近年来,行政区划调整成为优化资源配置和空间治理的重要抓手。行政区划设置在完善城市布局、优化城市结构、提高空间治理效率、调节空间发展秩序、促进区域均衡发展和实现区域优化重组等方面发挥重要作用。建议在"十四五"期间,充分发挥行政区划的资源优化配置作用,推进城市群专区行政管理体制改革、因地制宜推进各级中心城市建设步伐,提高中心城市综合承载和资源优化配置能力,优化县级行政区设置与布局,激发地方发展活力,推进扁平化管理,提高空间治理效率。同时,提出进行政区划调整的配套政策与建议,为中国新时期的空间治理和区域协调发展作出应有的贡献。     

Cr12MoV模具钢激光涂层的耐磨性能分析

分析Cr12MoV模具钢激光涂层的耐磨性能。本文通过摩擦磨损实验测出经过激光熔覆处理后的Cr12MoV模具钢耐磨性和没有经过处理的Cr12MoV模具钢耐磨性的数据,再对数据进行计算、观察、分析作出相应的对比曲线图,以此来研究Cr12MoV模具钢图层的耐磨性。     

Overexpression of Aldose Reductase Render Mouse Hepatocytes More Sensitive to Acetaminophen Induced Oxidative Stress and Cell Death

Acetaminophen (APAP) a commonly used drug for decrease the fever and pain but is capable to induced hepatotoxicity at over dose. This study was carried out to investigate the effect of APAP on the expression of anti-apoptotic and antioxidative defense genes, and whether aldose reductase over-expressing plasmid capable to protect against APAP-induced oxidative stress and cell death. APAP treatment induced oxidative stress and hepatotoxicity, and significantly increased aldose reductase mRNA and protein expression in mouse hepatocyte (AML-12). Unexpectedly, AML-12 cells over-expressing aldose reductase augmented APAP-induced reduction in cell viability, reactive oxygen species (ROS) production, glutathione (GSH) depletion and glutathione S-transferase A2 expression. Moreover, over-expression of aldose reductase potentiated APAP induced reduction on proliferating cell nuclear antigen, B cell lymphoma-extra large (bcl-x_L), catalase, glutathione peroxidase-1 (GPx-1) and abolished APAP-induced B-cell lymphoma 2 (bcl-2) inductions. Further, over-expression of aldose reductase significantly abolished AMP activated protein kinase (AMPK) activity in APAP-treated cells and induced p53 expression. This results demonstrate that APAP induced toxicity in AML-12, increased aldose reductase expression, and over-expression of aldose reductase render this cell more susceptible to APAP induced oxidative stress and cell death, this probably due to inhibition AMPK or bcl-2 activity, or may due to competition between aldose reductase and glutathione reductase for NADPH.     

血管内皮生长因子和白细胞介素-12在急性白血病中的表达及临床意义

目的 通过检测急性白血病（AL）患者静脉血清中血管内皮生长因子（VEGF）和 白细胞介素12（IL-12）的含量，探讨VEGF和IL-12在急性白血病中的含量及临床意义。方法 应用定量酶联免疫吸附实验测定10例初诊未治、10例缓解期、5例复发患者和9例正常对照血清中VEGF和IL-12的含量。结果 初诊未治组的VEGF含量（521.06±163.85pg/ml）明显高于缓解组（307.62±55.40pg/ml）及对照组（262.01±141.66pg/ml）（p均<0.05）。对照组的IL-12水平（58.96±38.11pg/ml）与初诊复发组（初诊未治组与复发组的合称32.51±14.58pg/ml）、缓解组（71.67±119.09pg/ml）之间均有显著性差异（p均<0.05）。正常对照组VEGF的含量与IL-12之间存在负相关性。结论 VEGF和IL-12与AL的病情变化有一定的关系。     

College selectivity and young adult health behaviors

Large literatures have shown important links between the quantity of completed education and health outcomes on one hand and the quality or selectivity of schooling on a host of adult outcomes, such as wages, on the other hand. However, little research attempts to produce evidence of the link between school quality and health. The paper presents the first evidence in the literature on the potential short and intermediate term effects of attending a selective college on health behaviors during and following college attendance. Using a variety of empirical methods, this paper shows strong evidence that college selectivity reduces tobacco and marijuana use but has small and possibly positive effects on binge drinking. The effects on weight behaviors are suggestive of reduced weight, potentially through diet, but not exercise change.     

Poisoning the mind: Arsenic contamination of drinking water wells and children's educational achievement in rural Bangladesh

Bangladesh has experienced the largest mass poisoning of a population in history owing to contamination of groundwater with naturally occurring inorganic arsenic. Prolonged drinking of such water risks development of diseases and therefore has implications for children's cognitive and psychological development. This study examines the effect of arsenic contamination of tubewells, the primary source of drinking water at home, on the learning outcome of school-going children in rural Bangladesh using recent nationally representative data on secondary school children. We unambiguously find a negative and statistically significant correlation between mathematics scores and arsenic-contaminated drinking tubewells at home, net of the child's socio-economic status, parental background and school specific unobserved correlates of learning. Similar correlations are found for an alternative measure of student achievement and subjective well-being (i.e. self-reported measure of life satisfaction), of the student. We conclude by discussing the policy implication of our findings in the context of the current debate over the adverse effect of arsenic poisoning on children.     

The impact of education on health knowledge

The theory on the demand for health suggests that schooling causes health because schooling increases the efficiency of health production. Alternatively, the allocative efficiency hypothesis argues that schooling alters the input mix chosen to produce health. This suggests that the more educated have more knowledge about the health production function and they have more health knowledge. This paper uses data from the 1997 and 2002 waves of the NLSY97 to conduct an investigation of the allocative efficiency hypothesis by analyzing whether education improves health knowledge. The survey design allows us to observe the increase in health knowledge of young adults after their level of schooling is increased by differential and plausibly exogenous amounts. Using nine different questions measuring health knowledge, we find weak evidence that an increase in education generates an improvement in health knowledge for those who ultimately attend college. For those with high school as the terminal degree, no relationship is found between education and health knowledge. These results imply that the allocative efficiency hypothesis may not be the primary reason for why schooling impacts health outcomes.