不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制研究

目的：探讨不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制。方法：将雄性Wistar大鼠50只随机均分为5组：安静对照组（C）、低负荷运动训练组（LT）、中等负荷运动训练组（MT）、高负荷运动训练组（HT）和极高负荷运动训练组（ST），每组10只。各运动组分别进行6周的跑台运动训练。训练方案结束后，取腓肠肌样本，提取线粒体，测定线粒体柠檬酸合成酶（CS）、异柠檬酸脱氢酶（ICD）和α-酮戊二酸脱氢酶（α-KGDHC）活性；线粒体Ga²⁺含量、胞浆NADH、NAD⁺、ATP和ADP含量，以及ICD mRNA转录水平。结果：（1）不同负荷运动训练组线粒体CS、ICD和α-KGDHC的活性均显著高于安静对照组（P < 0.01），且CS和ICD活性由高到低顺序均为：MT组 > HT组 > ST组 > LT组 > C组，α-KGDHC活性由高到低顺序为：HT组 > MT组 > ST组 > LT组 > C组。（2）不同负荷运动训练组线粒体Ca²⁺ 含量均显著高于安静对照组（P < 0.01），其含量由高到低顺序为：MT组 > HT组 > ST组 > LT组 > C组；胞浆NADH/NAD⁺和ATP/ADP的比值均显著低于安静对照组（P < 0.01），其比值由低到高顺序为：MT组 < ST组 < HT组 < LT组 < C组。（3）不同负荷运动训练组ICD mRNA转录水平均高于安静对照组（P < 0.01），其水平由高到低顺序为： MT组 > HT组 > ST组 > LT组 > C组。结论：低负荷、中等负荷、高负荷及极高负荷运动训练均可提高大鼠骨骼肌线粒体三羧酸循环功能，且中等负荷运动训练效果最佳。其机制与胞浆NADH/NAD⁺和ATP/ADP比值、线粒体摄钙能力及限速酶基因的表达有关。     

Discrete Choice Modeling in Education: An Innovative Method to Assess Teaching Practices

Self‐reported measures are an easy, time‐efficient, and low‐cost way to collect research data compared to other assessment methods. They are, however, characterized by several limitations regarding the quality and the clarity of the data they produce, especially when they are implemented in education. The main purpose of the current study was to use a method called discrete choice modeling (DCM) in education, in order to develop a self‐reported instrument that will reduce the bias for socially desirable responses and to assess teachers’ practices in physical activity. DCM method has the ability to overcome the respondents’ tendency to answer in a socially desirable way. A nationally representative sample of 531 Greek early educators participated in this study and were administered a self‐assessment questionnaire based on DCM. Results showed that the DCM based newly developed instrument manages to assess effectively educators’ practices and provided evidence of the applicability of the method in education. Further implications and future recommendations regarding the effective application of DCM in education are discussed.     

Evaluating the international dimension in an undergraduate curriculum by assessing students’ intercultural sensitivity

This formative, outcome-oriented, theory-based evaluation research study assessed the effectiveness of requiring an international (‘I’) course by measuring students’ intercultural sensitivity (IS) at the start and end of a semester. Findings revealed that students’ IS scores did not change regardless of the type of class in which the student was enrolled and were not significantly different based on gender, age, ethnicity, undergraduate classification, or number of ‘I’ courses taken. There were significant differences in IS based on religion, traveling outside the US, participating in a study abroad course, and the number of cultural events in which the student had participated. Regression analysis confirmed that religious affiliation and number of times traveled outside the US were significant predictors of IS. This study is an example of the use of theory-based evaluation in an educational system and provides important insights into what experiences affect college students’ IS.     

高职院校顶岗实习管理机制构建探析

顶岗实习是实现高职人才培养目标的重要途径。鉴于当前高职顶岗实习中学校、学生及教师各层面都存在的问题,重新设计了顶岗实习的流程体系,通过校、企、师、生、家五方联动,构建了五途径保障实习岗位、两维度驱动实习成效、四层次规范实习管理、三主体强化实习评价的“五二四三”顶岗实习模式,实现学生、企业、教师、家长、导师和学校的六方共赢。     

A Bioethos for Bodies: Respecting a Priceless Resource

The value that willed body donors provide to medical education is priceless. Their precious gift helps to teach anatomy, spatial relationships between morphological structures, anatomical variation, and professionalism to medical students in a way that plastic models, podcasts, and lectures cannot. They are also an important resource for medical research and a wide variety of postgraduate training opportunities. While many body donation programs throughout the world are nonprofit organizations, there are body donation companies in the United States that sell donors for-profit. These “body brokers” have accumulated large profits from this business. It is incongruous that others would profit from such a priceless, freely donated gift. To prevent this incongruity, it is proposed that the international anatomical community develop a normative culture (a bioethos) for body donation programs. This would involve the conscious and systematic development of ethical principles for the day-to-day policies and practices of institutions that collect and use human bodies. With the development of this bioethos, a cultural shift in how donors are treated would occur and, over time, this would become the normal practice. These principles would become fundamental and foundational for the procurement and use of priceless human tissues.     

分层教学模式在高中体育教学中的运用

随着现代教育的不断推进,在阳光体育的背景下,体育备受教育部门和学校的关注。本文针对学校体育教学中存在的一些问题,结合学校体育的发展的特点,让分层教学模式走进学校体育的课堂,通过分层教学,打破了传统的"一锅煮"的教学模式,让不同层次的学生通过自己不懈的努力,体育成绩都能得到发展。通过这样的教学模式,不仅把学生的眼球吸引到体育教学的课堂,而且促进学生体育学习的积极性,使得体育课堂活起来,为学生的终身体育学习打下良好的基础。     

论竞技体育对学校体育的影响

举国体制下,竞技体育对我国群众体育和学校体育的发展有着重要的引领作用。在国家大力推进"体教融合"的今天,探究竞技体育对学校体育发展的影响显得尤为必要。据此,本研究分别从竞技体育对学校体育文化的影响、对学生人格发展的影响、对学校体育教学的影响3个角度进行了论述,旨在为促进我国体教融合,推动学校体育健康有序发展提供思路。     

我国现阶段乡村农民体育观念的调查与研究

采用文献研究、下乡访谈、问卷调查、数理统计、多因素分析等方法,以我国20个省、区、市部分农民(户)为研究对象,对他们参与全民健身、享受体育的现状进行调查,力求探索出一条以城市带动乡村来提高我国整体体育人口比例的道路。研究结果显示:我国9亿农民在富民政策指引下,92％基本解决“温饱”问题。“温饱”之后思什么?农民是否愿意在自己农闲时间中给体育留有一席之地?他们对健康的渴求、精神的愉悦、消费的倾向如何?需要全社会来引导与关注。     

学校体育对中小学生心理健康教育影响作用探讨

通过文献资料研究、社会调查、专家访谈和比较分析等研究方法，对我国部分地区中小学生心理健康状况进行了调查分析，并运用体育学、保健学、教育学和心理学等学科理论知识与研究成果，探讨了学校体育对中小学生心理健康教育影响的积极效应与促进作用。     

试论北京奥运会前我国青少年的奥林匹克教育问题

在我们积极准备举办2008年奥运会的时候，我们必须开展奥林匹克教育，尤其是在青少年中应把奥林匹克教育放在十分重要的位置。本文从奥林匹克思想的主线入手，阐述了教育是奥运会最重要的功能，较客观地分析了我国青少年奥林匹克教育的现状，以及在此基础上提出北京奥运会前深入开展青少年奥林匹克教育的对策和建议。