消化性溃疡病患者胃窦粘膜幽门腺5-HT细胞和G细胞免疫组织化学研究

胃溃疡(Gu)、十二指肠溃疡(Du)和对照组(Con)各5例,取肉眼下非病变区胃窦粘膜,用免疫组织化学PAP双重染色法,在同一张切片上显示5-HT细胞和G细胞。结果5-HT细胞多散在于粘膜的中下1/3,呈棕褐色,形状多样,常见有突起的细胞。G细胞呈带状分布于粘膜的中1/3,大部分G细胞为蓝色,个别细胞为蓝黄混合色。它们多为圆形或锥体形。有时可见5-HT细胞和G细胞相毗邻。5-HT细胞数和G细胞数在Gu组分别为:4.17±1.21、7.87±3.13;Du组:5.45±1.96、9.21±5.72;Con组:3.21±1.64、6.19±1.72。5-HT细胞数和G细胞数在Gu组和Du组都增加。且都以Du组为最多,经相关分析二者呈正相关关系。Gu和Du组的5-HT细胞数和G细胞数与对照组相比均有高度显著性差异。Du组的5-HT细胞数和G细胞数与Gu组相比较,亦有高度显著性差异。提示5-HT细胞和G细胞可能参与了消化性溃疡病的调节,特别与Du的关系更为密切。5-HT细胞和G细胞之间的关系有待于进一步研究。     

腹腔镜十二指肠溃疡穿孔修补12例报告

目的 评价腹腔镜修补十二指肠球部溃疡穿孔的效果。方法 对12例十二指肠球部溃疡穿孔的病人行电视腹腔镜缝合修补，观察其疗效及并发症。结果12例均在腹腔镜下成功修补，术后恢复快，平均住院6天，无手术并发症。结论 电视腹腔镜十二指肠球部溃疡穿孔修补术是安全有效的手术方法。     

低频脉冲电流治疗慢性胃炎和溃疡病48例

本文报告了用低频脉冲电流治疗慢性胃炎和溃疡病48例。其中治愈38例,显著好转6例,好转2例,无效2例。文中列举了2个典型病例,并讨论了治疗机理。     

止血药的临床应用进展

大量失血已成为造成患者死亡的首要原因。因此如何快速、有效、安全的止血是挽救患者生命的关键所在。研究表明,传统止血药物在发挥止血效应时存在一定的副作用,而近年来文献报道的新型止血药物研发大多从中药与西药结合、物理与化学机制结合和凝血与抗凝血功能平衡的角度出发。本文对止血药物及其研发思路进行综述,为进一步在临床开展创伤止血提供参考。     

论几类特殊毒品流通行为的法律认定

按照部分学者的观点,贩卖毒品罪的本质属性是客观上使毒品发生流转,只要使毒品流通,一般可将该行为认定为贩卖毒品罪。事实上,这样的认定有违刑法谦抑原则,而且过于武断,以此将互易毒品行为、用毒品与其他非物质利益进行交换的行为、居间介绍买卖毒品的行为、委托他人代购毒品一概以贩卖毒品罪来论处,有失偏颇。     

Clinical Pharmacology: A Comprehensive Drug Reference

Abstract

This column discusses the point-of-care tool Clinical Pharmacology. This review is primarily intended for newer health sciences librarians who are learning about drug references and clinical decision-making support systems or health sciences librarians making collection development decisions, although any librarian will find this review useful. A sample search will be provided to highlight the database’s unique features as well as a comparison to other resources.     

高通量筛选技术中数学模型的建立

在高通量药物筛选中,数学模型被认为是实现对样品库大规模筛选及筛选过程自动化的基础。从热力学及动力学的角度对药物筛选的原理与方法进行了分析研究;同时也对药物与靶点的3种可能的作用体系进行了研究,获得了药物筛选过程的热力学与动力学综合模型和基础数学模型。     

THE RELATIONSHIP BETWEEN ULCER RECURRENCE AND HELICOBACTER PYLORI: A PROSPECTIVE ONE-YEAR FOLLOW-UP STUDY IN CHINA

ＩＮＴＲＯＤＵＣＴＩＯＮＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉａｓｏｎｅｏｆｔｈｅｍａｊｏｒｐａｔｈｏｇｅｎｔｉｃｆａｃｔｏｒｓｉｎｐｅｐｔｉｃｕｌｃｅｒｈａｄｂｅｅｎｉｄｅｎｔｉｆｉｅｄ(ＮＩＨ,1994).Ｍｏｒｅｔｈａｎ90%ｏｆｐａｔｉｅｎｔｓｗｉｔｈｄｕｏｄｅｎａｌｕｌｃｅｒａｎｄ85%ｏｆｐａｔｉｅｎｔｓｗｉｔｈｇａｓｔｒｉｃｕｌｃｅｒｈａｄａｔｔｈｅｓａｍｅｔｉｍｅＨ.ｐｙｌｏｒｉｉｎｆｅｃｔｉｏｎｉｎｇａｓｔｒｉｃａｎｔｒｕｍｗｈｉｃｈｌｅａｄｓｔｏｃｈｒｏｎｉｃａｃｔｉｖｅｇａｓｔｒｉｔｉｓ(Ｔ…     

SRB显色法用于抗癌药物敏感性试验的研究

采用ＳＲＢ显色法对９６孔培养板中短期培养的人大肠癌细胞株Ｃｏｌｏ２０５、人骨肉瘤细胞株ＯＳ７３２,人舌癌细胞株Ｔｃａ８１１３经５－ＦＵ,顺铂,蟾酥等药物处理后的活性进行了研究。结果表明,ＳＲＢ法对这些细胞株的体外抗癌药物敏感试验结果稳定,该法与其它细胞毒试验相比有一定优点,值得推广应用。     

“Tightening the Knots” of the International Drugs Trade in Brazil

Much academic analysis of media representations of drugs-related violence in Brazil has focused on their role in perpetuating violence and societal divisions. There is less research on how the country’s traditional news media can shape information in order to foster dialogue between people and potentially resolve conflict. This article aims to address this gap by exploring the possibilities and challenges for printed news media to acquire “mediated” social capital. The concept is understood here as a specific resource of power that has the potential to connect people from diverse social, cultural and economic backgrounds. In order to do so, we analyse how a popular Rio newspaper has used its symbolic power to produce social capital with an investigative series about Brazil’s involvement in the international drugs trade. It is argued here that the series paints a complex picture of its causes and consequences and is an important step towards a deliberative process about possible solutions to drugs-related violence in Rio and beyond.