柳氮磺吡啶片近红外一致性检验方法研究

本文通过收集共32个批次的柳氮磺吡啶片样品,经实验室检验后,扫描其近红外光谱,结合实验室的检测结果,运用OPUS 5.0软件,建立柳氮磺吡啶片的一致性检验模型,并用新的样品来验证模型的准确性。本方法简便快捷,可以在不破坏包装的情况下准确鉴别柳氮磺吡啶片的真伪。     

Concatenated Trellis Coding and CPM for DS/SSMA Communications in Rayleigh Fading Channel

本文在衰落信道下将级联网格编码调制（ＴＣＭ）和连续相位调制（ＣＰＭ）应用于直接序列扩频多址（ＤＳ／ＳＳＭＡ）系统中．作者分别采用了理论分析和数值模拟两种方法研究了级联ＴＣＭ／ＣＰＭＤＳ／ＳＳＭＡ系统的性能，结果表明在相同的条件下采用级联ＴＣＭ／ＣＰＭ编码调制方式的ＤＳ／ＳＳＭＡ系统的错误概率远小于采用单一ＴＣＭ或ＣＰＭ的ＤＳ／ＳＳＭＡ系统的错误概率．     

Design and development of VR learning environments for children with ASD

Basic social interaction and executing certain tasks can be difficult for children with autism spectrum disorder (ASD). The symptoms of such behaviour include inappropriate gestures, body language and facial expressions, lack of interest in certain tasks, cognitive disability in coordination of limbs, and a difficulty in comprehending tasks’ requirements. This paper will discuss our efforts to develop virtual learning environments for children with ASD to improve their gestures and their interests in comprehending tasks’ requirements. Virtual environments are ideal for imparting skills necessary for independence before encouraging children with ASD to try these out in the real world and gain real-life experience. A high-end solution and a simplified solution will be presented together with a discussion on their comparison study.     

宁夏太阳辐射资源时空变化规律研究

本文用功率谱方法和最小二乘法研究了宁夏太阳辐射资源的时空变化规律。研究结果表明，太阳辐射资源在空间变化上呈现出明显的地域分异规律，日照时数、日照百分率及太阳辐射总量在地区分布上呈现出明显的南少北多、南小北大的地域分异规律；太阳辐射资源呈现出明显时间变化规&功率谱、最小二乘法、太阳辐射资源、宁夏     

The disease burden of childhood adversities in adults: a population-based study

Objectives

There is much evidence showing that childhood adversities have considerable effects on the mental and physical health of adults. It could be assumed therefore, that the disease burden of childhood adversities is high. It has not yet been examined, however, whether this is true.

Method

We used data of a large representative sample (N = 7,076) of the general population in the Netherlands. We calculated the disability weight (DW) for each respondent. The DW is a weight factor that reflects the severity of a disease or condition on a scale from 0 (perfect health) to 1 (equivalent to death). We used an algorithm based on the SF-6D to estimate DW. Because the DW indicates the proportion of a healthy life year that is reduced by the specific health state of the individual, it also possible to calculate the total number of years lost due to disability (YLD) in the population. We calculated the years lived with disability (YLD) for 9 different childhood adversities (in the areas of parental psychopathology; abuse and neglect; major life events), as well as for major categories of mental disorders and general medical disorders.

Results

All 9 adversities resulted in a significantly increased DW, except death of a parent before the age of 16. Adversities in the category of abuse and neglect are associated with the highest DWs (0.057), followed by parental psychopathology (0.031) and life events during childhood (0.012). All adversities (46.4% of the population reports one or more adversity) are associated with 20.7 YLD/1,000, which is more than all mental disorders together (12.9 YLD/1,000). The category of abuse/neglect has the highest YLD/1,000 (15.8), which is also higher than all mental disorders together. Adjustment for the presence of mental and general medical disorders resulted in comparable outcomes.

Conclusions

Childhood adversities are more important from a public health point of view than all common mental disorders together, and should be a priority for public health interventions.     

Diagnosis of Major Organic Acidurias in Children: Two Years Experience at a Tertiary Care Centre

Organic acid disorders are inherited metabolic disorders in which organic acids accumulate in tissues and biological fluids of affected individuals. Classical organic acidurias include methylmalonic aciduria, propionic aciduria, isovaleric aciduria and maple syrup urine disease (MSUD). They are considered the most frequent metabolic disorders among severely ill children. Patients frequently present with acute symptoms early in life. 420 cases clinically suspected to have organic aciduria, with upper age limit of 12 years for a 2-year period (January 2007–December 2008) were enrolled into this study. Metabolic acidosis and neurological symptoms were the most common signs. Screening tests and thin layer chromatography were done for detection of organic acidurias. Identification and quantitation of organic acids in urine and quantification of amino acids in blood were done by high performance liquid chromatography. Out of 420 patients, 45 patients (10.7%) were found to have organic acidurias. 15 cases of methylmalonic aciduria, 16 cases of propionic aciduria, 13 cases of MSUD, and one case of isovaleric aciduria were diagnosed. Results demonstrate the importance of testing for organic acidurias. Since organic aciduria may cause irreversible brain damage if not treated, we recommend selective screening amongst severely ill children despite implied extra costs.     

紫外光谱法研究久效磷与碱基的相互作用

为利用组合化学原理构建核酸适体库,确定久效磷适体筛选缓冲体系的最适 pH 值及离子强度,采用紫外吸收光谱法研究了不同 pH 值及不同 Na ﹢、K ﹢和 Mg2﹢浓度的缓冲溶液中久效磷与四种碱基的相互作用。结果表明,pH 值及 Na ﹢、K ﹢和 Mg2﹢浓度对久效磷与四种碱基的作用有明显的影响,pH7.6、Na ﹢浓度200 mmol/ L、K ﹢浓度40 mmol/ L、Mg2﹢浓度15 mmol/ L 的50 mmol/ L Tris 缓冲溶液中久效磷与四种碱基的作用相对较强,可以作为久效磷适体筛选的参考缓冲体系。在此缓冲体系下,久效磷与四种碱基作用的强弱依次为胞嘧啶、胸腺嘧啶、腺嘌呤、鸟嘌呤。因此,构建核酸适体库时可以适当增加胞嘧啶、胸腺嘧啶的比例。     

高功能自闭症儿童沙盘干预的个案研究——基于自闭症谱系认知理论的分析

通过对一名高功能自闭症儿童进行为期8个月的沙盘干预,探讨沙盘对于高功能自闭症儿童的治疗效果,并用自闭症谱系认识理论进行分析。结果发现,个案使用的沙具由单一变得多样化,主动性言语增多,刻板重复言语等症状不同程度地减少。该个案的沙盘表现支持ToM及相关理论。     

酞菁铁Ⅱ与牛血清白蛋白相互作用的光谱研究

研究酞菁铁Ⅱ与牛血清白蛋白的相互作用,测定了二者相互作用的荧光光谱和紫外可见光谱.荧光光谱分析表明,随着酞菁铁Ⅱ浓度的增加,后者在345 nm处荧光有规律的发生猝灭现象.根据Stern-Vo Lmer方程可以计算得到两者相互作用的猝灭常数为1.25×104,结合位点数为1.由紫外可见光谱可知,随着酞菁铁Ⅱ浓度的增加,牛血清白蛋白在210 nm处吸光度有所上升,峰位发生红移.     

Pre-service teachers’ perceptions of simSchool as preparation for inclusive education: a pilot study

The shift towards the inclusion of students with disabilities in regular schools has meant that general classroom teachers need to be skilled in educating students with a diverse range of needs and abilities. Together with theoretical study and as a supplement to practical experience, teacher educators have begun to explore virtual and simulated classrooms to help prepare pre-service teachers for the complexity of the teaching profession. In this pilot study, we examined the perspective of pre-service teachers on a classroom simulation program called “simSchool.” Two-hour-long tutorial sessions focusing on catering for student diversity and the educational needs of students with autism spectrum disorder were conducted. The pre-service teachers’ responses to an 11-item questionnaire are discussed, highlighting the potential of simSchool as well as some current limitations of this approach in the context of Australian teacher education courses.