Off-pump coronary artery bypass grafting versus on-pumpcoronary artery bypass grafting: which is better in patients with chronic obstructive pulmonary disease?

INTRODUCTION Conventional coronary artery bypass graftin(CCABG) with cardiopulmonary bypass (CPB) habeen accepted as an effective and safe treatment fomulti-vessel coronary heat disease. CPB may stilcontribute to the operation field because of threlatively easier technical requirement; but it alscauses a serious systematic inflammatory reactiowhich will lead to dysfunction of important organand higher cost for the patients. Off-pump coronarartery bypass grafting (OPCABG) has r…     

指导学生制作OTP单片机型脉搏心率计

单片机是计算机发展的一个方面,是现代智能化仪器的核心.51单片机是我国大力推行的一种单片机机型,OTP单片机是与51机兼容而且具有加密功能的一次性编程单片机,指导学生用汇编语言编程,有利于熟悉和掌握单片机的工作原理及编程步骤.EWB电子工作平台为外围硬件电路设计提供仿真.     

阿尔兹海默症患者的语义记忆损伤:表现、理论及展望

图片命名、范畴流畅性等神经心理学测验表明,阿尔兹海默症(AD)患者普遍存在语义记忆的损伤,并随着病程的发展表现出进行性与弥散性特点。AD患者语义记忆的损伤既可能由语义知识的存储障碍造成,也可能由语义知识的提取障碍引发,还可能由存储与提取的双重损伤造成。未来研究应开发出对早期AD检测更为敏感的语义记忆测验,并采用横向与纵向多种研究技术与手段,考虑不同语言文化背景下AD患者语义损伤的情况,以综合分析AD患者语义记忆损伤的实质及其发展趋势。     

试论南唐词的儒家文化意蕴

“诗言志”与中和雅正是儒家诗教的重要内容。南唐词因受儒家文化的影响而具有儒家文化意蕴，其具体表现一是运用清乐词调，变花间促碎之音为清和雅缓之乐；二是抒写忧患意识和人生感慨；三是典雅的艺术风貌。南唐词因此对宋词题材的扩大和词的“雅化”产生了较大影响，它是从花间词到北宋词过渡的重要环节。     

"脑死亡"的价值与挑战

脑死亡是由当代科学和医学技术进步给我们带来的一个全新问题，也涉及到复杂的经济、社会、伦理和法律等问题。脑死亡的提出意味着对于生和死的判别由经验转向了科学；凸显了大脑和心脏在人的生命系统和自我认同中的不同地位。在相当长的时期内，对于大多数社会成员来说，脑死亡标准不一定意味着对于心死亡标准的截然取代。而是将与其并存。脑死亡的实施提出了抢救生命的价值、代价和极限问题，将对生命终结标准的选择权和宣判权提出挑战，也将对人们通常的“孝”和“敬”等观念提出挑战。脑死亡的一个重要价值是有利于器官移植，而让生命以此种方式得以延续值得提倡。因此应当以一种更加开放的和进步的心态来积极推进有关脑死亡的立法。     

非人灵长类模型

全球有近10亿脑疾病患者,每年约带来经济负担1万亿美元。目前,绝大部分脑疾病尚无有效治疗方法。因此,脑疾病机理研究和新药开发十分迫切。由于进化上相近,非人灵长类的脑在结构、功能活动等多方面与人类高度相似。因此,相对于其他实验动物,非人灵长类具有解决人类问题,特别是脑相关问题的独特优势。它们除了是研究人类正常脑高级功能的关键实验动物外,还是最好的研究脑疾病机理和治疗方法的模型动物。中国不但有丰富的非人灵长类资源,而且在猕猴建模方面有很好的积累,尤其在转基因疾病猕猴模型创建方面,目前处于世界领先的地位。文章分析了脑疾病领域的国家战略需求,总结了国内外非人灵长类的应用情况,以及国内非人灵长类模型现状。在此基础上,对我国非人灵长类模型领域下一步发展的重点提出了建议。     

Troponin T and Heart Type Fatty Acid Binding Protein (h-Fabp) as Biomarkers in Patients Presenting with Chest Pain

Acute coronary syndrome (ACS) is a term for a range of clinical signs and symptoms suggestive of myocardial ischemia. It results in functional and structural changes and ultimately releasing protein from injured cardiomyocytes. These cardiac markers play a major role in diagnosis and prognosis of ACS. This study aims to assess the efficacy of heart type fatty acid binding protein (h-FABP) as a marker for ACS along with the routinely used hs-TropT. In our observational study, plasma h-FABP (cut-off 6.32 ng/ml) and routinely done hs-Trop T (cutoff 0.1 and 0.014 ng/ml) were estimated by immunometric laboratory assays in 88 patients with acute chest pain. Based on the clinical and laboratory test findings the patients were grouped into ACS (n = 41) and non-ACS (n = 47). The diagnostic sensitivity, specificity, NPV, PPV and ROC curve at 95 % CI were determined. Sensitivity of hs-TropT (0.1 ng/ml), hs-TropT (0.014 ng/ml) and h-FABP were 53, 86 and 78 % respectively and specificity for the same were 98, 73 and 70 % respectively. Sensitivity, specificity and NPV calculated for a cut-off combination of hs-TropT 0.014 ng/ml and h-FABP was 100, 51 and 100 % respectively. These results were substantiated by ROC analysis. Measurement of plasma h-FABP and hs-TropT together on admission appears to be more precise predictor of ACS rather than either hs-Trop T or h-FABP.     

自然"国心"鸡心岭"爱国游"的开发建议

在挖掘自然"国心"鸡心岭"爱国游"内涵的基础上,提出两点开发建议:第一,将镇坪烈士陵园列为爱国主义教育基地,使之成为对青少年学生进行革命传统教育的第二课堂;第二,在鸡心岭战场的制高点处,修建"陕西省全境解放纪念碑",进一步增强"祖国在我心中"的爱国情.     

Cell therapy in congestive heart failure

Congestive heart failure （CHF） has emerged as a major worldwide epidemic and its main causes seem to be the aging of the population and the survival of patients with post-myocardial infarction. Cardiomyocyte dropout （necrosis and apoptosis） plays a critical role in the progress of CHF; thus treatment of CHF by exogenous cell implantation will be a promising medical approach. In the acute phase of cardiac damage cardiac stem cells （CSCs） within the heart divide symmetrically and/or asymmetrically in response to the change of heart homeostasis, and at the same time homing of bone marrow stem cells （BMCs） to injured area is thought to occur, which not only reconstitutes CSC population to normal levels but also repairs the heart by differentiation into cardiac tissue. So far, basic studies by using potential sources such as BMCs and CSCs to treat animat CHF have shown improved ventricular remodelling and heart function. Recently, however, a few of randomized, double-blind, placebo-controlled clinical trials demonstrated mixed results in heart failure with BMC therapy during acute myocardial infarction.     

Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention

Objective: The beneficial effect of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has been well established, but there is the problem of no-reflow phenomenon which is an adverse prognostic factor in primary PCI. In the present study the effect of a distal protection device (PercuSurge GuardWire; GW) on epicardial blood flow and myocardial perfusion was evaluated. Methods and Results: Patients with AMI were randomly divided into 2 groups, the GW and the control groups. The GW group included 52 patients with AMI who underwent primary PCI with GW protection and the control group included 60 patients who underwent primary PCI without GW protection. Epicardial blood flow in the infarct-related artery (IRA) and myocardial perfusion were evaluated according to the thrombolysis in myocardial infarction (TIMI) flow grade and the myocardial blush grade (MBG). We found TIMI score of 3 was obtained significantly more frequently in the GW group (96%) than in the control group (80%). The MBG score of 3 was obtained also significantly greater in the GW group (65%) than in the control group (33%). Conclusion: Primary PCI with GW protection can significantly improve epicardial blood flow and myocardial perfusion.