试论求职者的能力培养

求职者职前的能力应通过教学活动、课外活动、自我实践活动进行培养和训练。     

教育功能:诠释,梳理

正确理解教育功能是进一步认识“什么是教育”的关键。目前,我国教育功能研究中最具代表性的两种功能观是个体功能与社会功能观和教育的正、负功能观,前者对教育功能的研究缺乏层次性、动态性和内在统一性,后者则曲解了“功能”的本义,将“功能”与“作用”混同,因而应对教育功能问题的研究进行重新审视,对教育功能重新界定,从而对教育功能进行结构改造,让教育功能的讨论与研究回归到教育本真意义上去。     

试论《雷雨》的音乐语言

曹禺以巴赫的作为贯穿<雷雨>序幕和尾声的背景音乐,是别有深意和匠心的.但是几乎没有研究者注意到这一音乐语言与文本的深层结构、精神内涵之间的深刻联系.巴赫是"西方音乐之父",其的复调、和声、对位等多种手法的高超运用所营造出的极为复杂的音乐结构和相当深刻的思想情感,对曹禺的文学创作发生了潜移默化的影响.<雷雨>有着明显的宗教氛围,突出了神秘与救赎的宗教精神.在戏剧结构和戏剧冲突的设置上,曹禺犹如一位交响乐指挥,以丰富复杂的复调结构把冲突推向高潮.     

The effect of marathon running on carnitine metabolism and on some aspects of muscle mitochondrial activities and antioxidant mechanisms

Carnitine is an essential co‐factor in the catabolism of fats as an energy source. The primary purpose of this study was to investigate the effect of running a marathon on the metabolism of carnitine by endurance‐trained athletes, and to evaluate the effect of carnitine administration on the performance of such exercise. The effects of marathon running on mitochondrial enzymes and cellular anti‐oxidants were also examined to assess whether the expression of these activities is altered by exercise. Subjects were 10 experienced male marathon runners aged between 19 and 25 years. Running a marathon caused a fall in the plasma content of unesterified carnitine (37%) and an increase in the level of acetylcarnitine present (288%). Loading of the athletes with L‐carnitine for 10 days before running a marathon abolished the exercise‐induced fall in plasma‐free carnitine (P<0.05) whilst amplifying the production of acetylcarnitine (P<0.05). Carnitine loading of the athletes studied made no detectable improvement in performance of the marathon (P > 0.05). Cytochrome oxidase, succinate cytochrome C reductase and Superoxide dismutase activities present in skeletal muscle were unaltered by marathon running. However, such exercise caused a large increase in the tissue content of oxidized glutathione (189%) at the expense of reduced glutathione (–18%).     

β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation

Objective

We investigated the influence of β-receptor blocker metoprolol on return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation (CPR) in rats with induced myocardial infarction (MI).

Methods

Male Sprague-Dawley rats were randomly divided into three groups: the sham-operated group, the MI group without metoprolol, which was fed the vehicle, and the MI+metoprolol group receiving intragastric metoprolol. Each group was further divided randomly into three subgroups, depending on the dosage of epinephrine administered during subsequent CPR applied after the induction of asphyxial cardiac arrest.

Results

The ROSC rate was significantly decreased in the low dose subgroup of MI group, unchanged in the medium dose subgroup of MI group, and significantly decreased in the high dose subgroup of MI group, compared with the same dose subgroup of sham-operated group. MI+metoprolol group had a lower ROSC rate than MI group in the medium dose subgroup, and a higher ROSC rate than MI group in the high dose subgroup. There was no difference in blood K⁺ values of successful rats between MI group and MI+metoprolol group. The rats with successful CPR had lower blood K⁺ values than rats with unsuccessful CPR in each of the three treatment groups.

Conclusions

Metoprolol administered to MI rats over a long period significantly improved ROSC rates under an appropriate dose of epinephrine during CPR. An increasing high blood K⁺ value would attenuate the rate of a successful CPR.     

跑台运动通过p38信号上调FNDC5激活Akt改善Ⅱ型糖尿病小鼠认知功能障碍

目的:探讨8周跑台运动对db/dbT2DM小鼠认知功能的影响及其分子机制。方法:24只8周龄db/dbT2DM小鼠和8只同龄对照m/m小鼠,将db/db小鼠随机分为:模型组(db/db)、运动干预组(db+Exe)、运动联合p38抑制剂组(db+Exe+SB203580)。db+Exe组进行8周跑台训练,db+Exe+SB203580组进行8周跑台运动联合SB203580抑制剂灌胃处理(5mg/kg,3d/W,8W)。每周定时检测小鼠的体重和空腹血糖;干预结束后,取全脑及海马组织,免疫组织化学染色观察海马不同区域的神经元损伤状态;Western Blot检测海马组织中AD样病理、神经炎症、突触可塑性、过氧化物酶体增殖物激活受体γ辅激活因子1α(PGC-1α)/Ⅲ型纤连蛋白组件包含蛋白5(FNDC5)、Akt激酶等蛋白的表达。结果显示:(1)跑台运动可明显改善db/db小鼠的认知功能障碍。(2)减轻db/db小鼠的海马神经元损伤。(3)降低海马内AD样病理、神经炎症蛋白的表达,增加突触蛋白的表达水平。(4)通过p38信号上调PGC-1α/FNDC5的表达。(5)跑台运动可激活Akt激酶,而p38抑制剂可降低跑台运动对Akt激酶的激活作用。结论:8周跑台运动可明显改善db/db小鼠的认知功能障碍,其机制可能是通过p38上调PGC-1α/FNDC5,激活Akt激酶,减弱AD病理进程,降低炎性反应,增加突触可塑性,改善其空间学习记忆能力。     

Digital ITEMS Module 1: Reliability in Classical Test Theory

In this ITEMS module, we provide a two‐part introduction to the topic of reliability from the perspective of classical test theory (CTT). In the first part, which is directed primarily at beginning learners, we review and build on the content presented in the original didactic ITEMS article by Traub and Rowley (1991). Specifically, we discuss the notion of reliability as an intuitive everyday concept to lay the foundation for its formalization as a reliability coefficient via the basic CTT model. We then walk through the step‐by‐step computation of key reliability indices and discuss the data collection conditions under which each is most suitable. In the second part, which is directed primarily at intermediary learners, we present a distribution‐centered perspective on the same content. We discuss the associated assumptions of various CTT models ranging from parallel to congeneric, and review how these affect the choice of reliability statistics. Throughout the module, we use a customized Excel workbook with sample data and basic data manipulation functionalities to illustrate the computation of individual statistics and to allow for structured independent exploration. In addition, we provide quiz questions with diagnostic feedback as well as short videos that walk through sample exercises within the workbook.     

Evaluation of Dimensionality in the Assessment of Internal Consistency Reliability: Coefficient Alpha and Omega Coefficients

In the lead article, Davenport, Davison, Liou, & Love demonstrate the relationship among homogeneity, internal consistency, and coefficient alpha, and also distinguish among them. These distinctions are important because too often coefficient alpha—a reliability coefficient—is interpreted as an index of homogeneity or internal consistency. We argue that factor analysis should be conducted before calculating internal consistency estimates of reliability. If factor analysis indicates the assumptions underlying coefficient alpha are met, then it can be reported as a reliability coefficient. However, to the extent that items are multidimensional, alternative internal consistency reliability coefficients should be computed based on the parameter estimates of the factor model. Assuming a bifactor model evidenced good fit, and the measure was designed to assess a single construct, omega hierarchical—the proportion of variance of the total scores due to the general factor—should be presented. Omega—the proportion of variance of the total scores due to all factors—also should be reported in that it represents a more traditional view of reliability, although it is computed within a factor analytic framework. By presenting both these coefficients and potentially other omega coefficients, the reliability results are less likely to be misinterpreted.