Oxidants and antioxidants in hypoxic ischaemic encephalopathy

In the present study, the role of serum lipid peroxide and serum nitric oxide as oxidants and erythrocytic superoxide dismutase & serum vitamin E as antioxidants were determined in the 50 neonates with hypoxic ischaemic encephalopathy. (HIE) as against 25 healthy neonates as controls 50 patients of HIE were further divided into two groups i. e. mild and moderate HIE patients. All subjects were in the age group of 37–41 weeks of gestation. The levels of serum lipid peroxide, serum nitric oxide and erythrocytic superoxide dismutase were significantly elevated in both groups of neonates with HIE than those of controls (P<0.001), whereas serum vitamin E levels were significantly decreased in both groups of HIE patients than those of controls (P<0.001). A positive correlation was obtained between serum lipid peroxide and erythrocytic superoxide dismutase (r=+0.86). Alterations in the status of oxidants and antioxidants indicate role of free radicals in the development of HIE.     

肝性脑病中医药治疗近况

近年来中医药在防治肝性脑病方面凸显出明显优势。为较全面的了解十几年来中医药在防治肝性脑病概况,文章收集了近十年左右相关的文献报道,通过归纳、分析、总结大量文献。先说明肝性脑病渊源,后分中医辨证论治、中药保留灌肠和其他复方治疗三个方面进行论述,以较全面地了解肝性脑病中医药治疗近况。     

Session - 6 December 19, 2007 Respiratory signal transduction mechanisms

In a prospective study of 47 patients of subclinical hepatic encephalopathy in cirrhosis of liver, aged between 23 and 60 years, 49% showed Helicobacter pylori positivity by rapid urease test. The baseline characters of patients (mean age, serum creatinine, sereum albumin, serum bilirubin, prothrombin time) were similar among patients with and without Helicobacter infection in all the patients. There was no statistically significant difference in blood ammonia levels in either group of patients. Blood ammonia values showed good correlation with the functional state of liver function but they did not show statistically significant difference between two groups of patients in any of Child Pugh classes. It is concluded that Helicobacter pylori does not contribute significantly to blood ammonia levels and the severity of hepatic encephalopathy.     

微生态制剂治疗肝性脑病的研究进展

肝性脑病（hepatic encephalopathy,HE）是由急、慢性肝功能衰竭或各种门-体分流（porto-systemic venous shunting,PSS）引起的以代谢紊乱为基础的、并排除了其它已知脑病的中枢神经系统失调综合征。常以神经精神症状,如性格改变、行为异常、智力减退等为突出表现,发病机制复杂,但经过合理、及时治疗后,该综合征具有潜在的可逆性。如何选择合理有效的药物预防和防止肝性脑病复发,逆转患者的精神神经系统失调已经成为目前研究热点。笔者针对目前微生态制剂药物组成、作用机制、临床疗效及其对治疗肝性脑病的研究进展做一综述。