抗体药物的研究进展

随着人们对抗体的结构与功能的了解不断深入,抗体不仅在抵抗外来生物物质方面有着重要作用,而且利用它本身的特点来防治疾病更是人们的研究热点。特别是单克隆抗体技术的问世,使得研究和生产单抗药物成为现实。本文就单抗药物的历史、现状、存在的问题及未来展望做一简要综述。     

基于深度学习的智能服药管理平台设计及应用

服药依从性差一直是药物治疗过程中面临的一大难题,尤其对中老年慢性病患者而言,遗忘是影响其服药依从性最主要的因素。据此设计一款基于深度学习的智能服药管理平台,该平台以物联网、数据挖掘技术为依托,以智能药盒为基础,联合手机APP、微信公众号和小程序等,具有用药计划创建、智能服药提醒、服药记录反馈等功能,还可以向患者提供用药资讯及多方服务监督功能。应用该智能服药管理平台可显著改善患者不规律服药的情况,减少漏服现象。     

高校校园文化信息发布体系流程再造的探索与实践

校园文化宣传是高校的重点工作之一,改变传统纸质、单一的文化信息发布形式,如何利用信息技术和流程再造的思想来完善校园文化信息发布体系,是各个高校需要去研究的内容。江苏农林职业技术学院通过构建多媒体信息发布系统,构建新型高校文化信息发布体系,完成对传统信息发布体系的改造,取得很好的效果。     

United States National Library of Medicine Drug Information Portal

The Drug Information Portal is a free Web resource from the National Library of Medicine (NLM) that provides a user-friendly gateway to current information for more than 15,000 drugs. The site guides users to related resources of NLM, the National Institutes of Health (NIH), and other government agencies. Current drug-related information regarding consumer health, clinical trials, AIDS, MeSH pharmacological actions, MEDLINE/PubMed biomedical literature, and physical properties and structure is easily retrieved by searching on a drug name. A varied selection of focused topics in medicine and drugs is also available from displayed subject headings. This column provides background information about the Drug Information Portal, as well as search basics.     

风对标枪飞行初始条件及远度的影响

根据标枪气动力风洞实验的数据 ,建立数学模型对不同风向和风速条件下的标枪飞行远度和最佳初始条件进行了计算机模拟计算和分析 ,为标枪运动员和教练员了解在有风条件下标枪的最佳出手角度和飞行远度的变化提供了定量数据     

关于标枪出手速度的效果测度灰色关联分析

通过对我国优秀女子标枪运动员投枪出手速度的效果测度灰色关联分析，揭示其有关因素对标枪出手速度所起的作用及地位。结果表明：影响标枪出手速度的首要因素是标枪离手时的左膝角，说明左腿迅速而充分的蹬伸对出手速度起着重要的影响作用。     

单杠上飞行动作撒手技术的运动学分析

着重从人体多环节链的相对运动来分析撒手时人体质心运动和翻转角动量的大小 ,并推导出了理论计算公式。研究认为 ,人体质心运动与翻转角动量大小由各环节之间复杂的相对运动关系所决定 ,随着人体运动环节数目的增加 ,分析这些环节的相对运动对人体质心运动和角动量的协同作用效果 ,将变得十分复杂。     

Moral Economies in Science: From Ideal to Pragmatic

In the following pages we discuss three historical cases of moral economies in science: Drosophila genetics, late twentieth century American astronomy, and collaborations between American drug companies and medical scientists in the interwar years. An examination of the most striking differences and similarities between these examples, and the conflicts internal to them, reveals constitutive features of moral economies, and the ways in which they are formed, negotiated, and altered. We critically evaluate these three examples through the filters of rational choice, utility, and American pragmatism, using the latter to support the conclusion that there is no single vision of moral economies in science and no single theory—moral, political, social—that will explain them. These filters may not be the only means through which to evaluate the moral economies examined, but aspects of each appear prominent in all three cases. In addition, explanations for decisions are often given in the language of these theories, both at the macro (policy) level and at the local level of the moral economies we discuss. In light of such factors, the use of these frameworks seems justified. We begin with an attempt to define the nature of moral economies, then move to a consideration of scientific communities as moral communities operating within material and other constraints which we relate to wider questions of political economy and societal accountabilities.

Properties of frictional bridging in fiber pull-out for fiber-reinforced composites

Stress equilibrium equations, boundary- and continuity-conditions were used to establish a theoretical model of progressive debonding with friction at the debonded interface. On a basis of the minimum complementary energy principle, an expression for the energy release rate G was derived to explore the interfacial fracture properties. An interfacial debonding criterion G≥Гi was introduced to determine the critical debond length and the bridging law. Numerical calculation results for fiber-reinforced composite SCS-6/Ti-6Al-4V were compared with those obtained by using the shear-lag models.     

抗人芽囊原虫药物筛选及灭滴灵对其作用机理

在体外,11种药物对人芽囊原虫作用的结果表明:人芽囊原虫对抗原虫药物灭滴灵、甲氟喹、喹碘仿敏感,对大蒜素不敏感;对抗蠕虫药物阿苯达唑、左旋咪唑、甲苯咪唑不敏感;对抗生素氯霉素和土霉素敏感,对庆大霉素和新霉素不敏感。灭滴灵作用虫体,扫描电镜观察,表面有蜂窝状凹陷及裂逢,透射电镜观察,细胞质内质网、高尔基体、细胞内膜及细胞核外膜破损,虫体细胞质出现空泡化和颗粒化。