基于RSS的Web信息发布和集成技术

就Web信息发布的及时性要求和集成问题，论述了RSS （RDF Site Summary）在解决这一问题时的综合运用。     

OAI注册服务器功能的探讨

OAI注册服务器提供了数据提供方和服务提供方基本信息的发布平台。本文首先说明了注册服务器存在的必要性，接着对一个完整的注册服务器的主要功能模块进行了介绍，并对注册服务器今后的发展进行了探讨。     

强迫症心理治疗方法的新进展

强迫症以反复出现的强迫观念或强迫行为为主要特征,是一种病因复杂、病情多变的常见精神疾病。本文对强迫症的心理治疗方法的最新进展进行了回顾总结,主要介绍了认知行为疗法、精神分析疗法、森田疗法对强迫症的治疗方式,并在最后介绍了心理治疗与药物治疗相结合的方法。发现对于强迫症的治疗多采用药物治疗和心理治疗相结合的方法。     

缓控释技术的研究进展

结合临床应用对缓控释制剂的类型进行综述,主要介绍骨架缓控释技术、渗透泵技术、定位释放技术、生物黏附技术、脉冲释放技术在制剂中的应用发展。     

吸毒人群增量的社会结构因素研究

自20世纪最后十年起,吸毒在中国日益成为一个显著的社会问题。中国社会科学界关于吸毒现象的研究,以定性研究和政策评估为主,且大多从吸毒者个体层面出发,去理解这一成瘾行为获得和戒除的社会机制。本文则尝试去回答这样一个问题,即在县级建制区层面,究竟哪些结构性因素决定了区域内毒情的发展趋势。利用公安部禁毒局网络数据终端“禁毒效果评估平台”中“区县信息”板块2006—2008三个年度的相关信息,采用负二项分布模型,以“新增吸毒人口数”这个反映区域毒品流行趋势的高效度指标为因变量,本文对理论假设的多组自变量———区域经济发展水平、区域（有助于毒情扩散的）风险因素和区域毒品社会控制力度———进行检验。作为以行政区域为分析单位的一个尝试性定量研究,为毒品控制这一研究领域贡献了初步的可积累知识。     

青少年吸毒的社会建构及其治理

我国每年登记在册的吸毒人数近年来整体呈现上升趋势,其中青少年吸毒人数的攀升更不容忽视。本文运用“个人是社会的产物而非起源”的视角展现了青少年吸毒同家庭结构与功能不完整、学校教育受损与同辈群体交往异常等因素之间的关联,分析青少年吸毒“心瘾”本质上呈现出麻木的快感、丧失自制、逃避现实等畸形心理特征。总体而言,青少年吸毒是由于其社会化过程中社会整合纽带受损或缺席导致。     

药品监管数字化的价值评估与实现途径

在深入剖解药品监管部门经费短缺且能力不足、制药企业刻意隐瞒、其他药评资料私密化等导致传统药监实效不彰之动因的基础上,阐明大数据环境下广域数据挖掘在实现药监元数据巨量化、引领药效认知科学化、减少涉药违规行为等方面的重要价值,提出包括改进用药数据挖掘技术、构筑病患信息加密认证系统、完善相关政策法规、适用惩罚性赔偿制度及提高第三方公开药评的物质奖励等在内的一系列推进药品监管数字化的具体举措。     

Molecular Mycobacteriology and Expansion in Disease Diagnosis

Molecular diagnostic tools for tuberculosis (TB) have evolved quickly with new innovations which can provide unprecedented opportunities for the rapid, sensitive and specific diagnosis of M. tuberculosis in clinical specimens and the status of its drug sensitivity. Microscopy and culture methods can not be replaced but the molecular assays can be applied in parallel with any new molecular tests for the diagnosis of TB. For extra pulmonary specimens, the use of the amplification methods is advocated, since rapid and accurate laboratory diagnosis is critical. Customization of the diagnostic usefulness of a molecular assay, according to the ease, reliability and need for health care sector is of immense value in a modern clinical mycobacteriology laboratory.     

Plasma Voriconazole Estimation by HPLC

Voriconazole, an antifungal drug exhibiting wide inter-individual variability, is an ideal candidate for therapeutic drug monitoring (TDM). The aim of the present study was to standardize a simple, sensitive and rapid high performance liquid chromatography (HPLC) method with ultraviolet detection to determine plasma voriconazole concentration. The HPLC method consisted of a combination of acetonitrile and water (7:3) as mobile phase with 1 ml/min flow rate and detection at 255 nm. Plasma protein precipitation was carried out using perchloric acid and the filtered supernatant was passed through C18 column (250 × 4.6 mm, 5 μm) for the separation of voriconazole. The limit of quantification of voriconazole was 0.2 mg/L. The assay was validated with a linearity of 0.2–15 mg/L and used clinically for TDM in patient samples. The inter-assay precision was below 15 % for routine quality control samples. Weight based voriconazole doses were prescribed to 26 patients for empirical treatment of invasive fungal infections. Voriconazole therapy was managed from the baseline drug levels and follow up analysis reflected achievement in clinical efficacy. Routine TDM of voriconazole may reduce adverse events and improve the treatment response in invasive fungal infections.     

Pharmacokinetic Models for Active Learning of Differential Equations

Abstract

We present adaptable activities for models of drug movement in the human body – pharmacokinetics – that motivate the learning of ordinary differential equations with an interdisciplinary topic. Specifically, we model aspirin, caffeine, and digoxin. We discuss the pedagogy of guiding students to understand, develop, and analyze models, progressing in complexity to a system of differential equations. We investigate the effects of parameter values that distinguish various health levels, and dosing that may have toxic effects. Our assignments include modeling in a student-centered, active, and increasingly inquiry-oriented setting through which the mathematics and biology inform and reinforce each other. We include supplemental information regarding inquiry methods, student learning outcomes, a student’s commentary about our activities, and support through mathematical communities such as POGIL and SIMIODE.