Thomson Reuters Integrity助力药物研发

详细介绍了Thomson Reuters Integrity数据库的信息源、整合的知识领域、服务人群以及数据库的特点和检索方式、统计分析功能、数据导出及跟踪管理等,总结了Thomson Reuters Integrity在药物研发各个阶段所起的作用,以便用户更便捷、更有针对性地使用。     

硝苯地平缓释胶囊释放度方法的建立

目的：建立硝苯地平缓释胶囊的释放度检查方法。方法：以盐酸溶液（9→100mL）1000mL溶出介质,转速为60r.min-1,取样时间为1h,4h,8h,采用释放度第一法,溶出度第二法测定。结果：硝苯地平在1.834-22.008μg.mL-1的浓度范围内,线性相关性良好。线性方程为：A=70580.3C-4008.4（r=0.9999）;平均回收率为100.4%,（RSD=1.14%）;6批样品在1h,4h,8h的释放量分别为标示量的15%-40%,30%-65%,50%-80%。结论：本方法便捷、准确、重现性好,可用于硝苯地平缓释胶囊的质量控制。     

办公楼节能环保设计

随着社会经济的迅速发展,能源问题也越发的迫切。倡导＂低碳生态、科技节能＂的建筑思想已经引起了人们的高度重视,在保证用电质量和用电安全的情况下,节约电能、降低能耗、提高经济效益,是当前急需解决的问题。笔者介绍了一个办公楼在设计过程中采用地源热泵系统、热水供应系统、LED照明灯具、太阳能光伏并网发电技术,实现零碳排放目标。     

学术文章更正内容和方式刍议

对已发表文章中的错误及时进行更正很少受到重视。通过错误类型和更正内容的分析,发现错误类型虽多,但更正内容却多以文字类和事实类等错误为主,较少关注影响较大的学术性错误。因此,在总结更正方式的基础上,进一步探讨了学术性错误的发现、更正方式,同时建议制定规范的更正制度以降低文字类和事实类的错误。     

某医院眼科2018-2019年Ⅰ类切口预防性使用抗菌药物调查分析

[目的]观察和分析眼科Ⅰ类切口围手术期预防使用抗菌药物的情况,为制定抗菌药物相关的管理制度提供相应的依据,进一步促进医生合理使用抗生素。[方法]采用回顾性的调查方法,选取2018年1月至2019年12月眼科Ⅰ类切口围手术期病例作为观察、分析的群体。采用随机的选择原则,每月选择5%眼科出院病人数,统计全身和局部抗生素的使用情况。[结果]眼科围手术期入选病例127例,共有29类眼科手术。全身预防性使用抗菌药物7例(5.51%),头孢呋辛选用率最高。给药途径包括静脉给药(6例)和口服给药(1例)。局部预防使用抗菌药物120例(94.49%),庆大霉素31例(24.41%),万古霉素14例(11.02%),红霉素27例(21.26%)。红霉素为点眼置于结膜囊,万古霉素和庆大霉素主要为冲洗。[结论]该医院眼科Ⅰ类切口围手术期患者使用抗生素预防感染以局部为主。不合理用药主要包括无需全身用药、药物品种选择不当、首次给药时机不适宜、用药疗程过长、无依据交替换药等问题,有待进一步规范。     

Molecular modeling: A powerful tool for drug design and molecular docking

Molecular modeling has become a valuable and essential tool to medicinal chemists in the drug design process. Molecular modeling describes the generation, manipulation or representation of three-dimensional structures of molecules and associated physico-chemical properties. It involves a range of computerized techniques based on theoretical chemistry methods and experimental data to predict molecular and biological properties. Depending on the context and the rigor, the subject is often referred to as ‘molecular graphics’, ‘molecular visualizations’, ‘computational chemistry’, or ‘computational quantum chemistry’. The molecular modeling techniques are derived from the concepts of molecular orbitals of Hückel, Mullikan and ‘classical mechanical programs’ of Westheimer, Wiberg and Boyd.     

鞍山地区毒品问题及对策研究

依据鞍山地区毒品状况 ,提出禁毒工作的对策和方法     

Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy

Red blood cell (RBC)-mimicking nanoparticles (NPs) offer a promising platform for drug delivery because of their prolonged circulation time, reduced immunogenicity and specific targeting ability. Herein, we report the design and preparation of RBC membrane-bound NPs (M@AP), for tumoral photodynamic-immunotherapy. The M@AP is formed by self-assembly of the positively charged aggregation-induced emission luminogen (AIEgen) (named P2-PPh3) and the negatively charged polyinosinic : polycytidylic acid (Poly(I : C)), followed by RBC membrane encapsulation. P2-PPh3 is an AIE-active conjugated polyelectrolyte with additional photosensitizing ability for photodynamic therapy (PDT), while Poly(I : C) serves as an immune-stimulant to stimulate both tumor and immune cells to activate immunity, and thus reduces tumor cell viability. When applied in tumor-bearing mice, the M@AP NPs are enriched in both the tumor region as a result of an enhanced permeability and retention (EPR) effect, and the spleen because of the homing effect of the RBC-mimicking shell. Upon light irradiation, P2-PPh3 promotes strong ROS generation in tumor cells, inducing the release of tumor antigens (TA). The anti-tumor immunity is further enhanced by the presence of Poly(I : C) in M@AP. Thus, this strategy combines the PDT properties of the AIE-active polyelectrolyte and immunotherapy properties of Poly(I : C) to achieve synergistic activation of the immune system for anti-tumor activity, providing a novel strategy for tumor treatment.     

Student Searches Policy Guidelines for Secondary Principals

In this article we argue that interactive writing (IW), an approach to writing instruction, is uniquely supportive of secondary content-area teachers working to integrate meaningful writing instruction without sacrificing time or attention to content. Drawing on research and our experiences with IW in middle school settings, we explain the roots of IW and its potential to support powerful writing instruction in the disciplines because of its emphasis on externalizing thought, negotiating meaning, and teaching conventions of writing and language in the context of real writing.     

Persons with Drug Addiction as Knowledge Providers: Their Contribution to Social Work Education

Social work students' stereotypical perceptions of excluded populations could be decisive in the way they treat those who are excluded. In an attempt to change such perceptions and enhance knowledge about how to work with an excluded population, a dialogue-in-class model was implemented between students of social work in Israel and persons with drug addiction. The experiences of 292 students were evaluated by utilizing a semi-structured instrument. The findings indicated the potential of this model (in which representatives of an excluded population are the knowledge providers) to expand and enrich the unidimensional and stereotypical way in which students may perceive persons with drug addiction. The participants drew implications for future practice with excluded populations. These included both the importance of coming to a fuller understanding of the unique difficulties and needs of each person and the necessity of overcoming barriers hindering connection with persons in excluded populations, thus reducing their sense of exclusion.