数据挖掘技术在连锁药店管理中的应用研究

以亳州盖福祥连锁药店为例,利用关联规则对数据库中药品的销售信息进行挖掘及利用NK—means聚类算法对顾客忠诚度进行聚类分析研究,找出影响连锁药店盈利的主要因素,为连锁药店改进营销策略、提高服务质量提供参考依据。     

民族地区药管专业实训教学面临的困境与对策--以广西民族师范学院为例

实训教学是技能培养的重要组成部分,在人才培养过程中越来越发挥出它的重要作用。民族地区药管专业在实训过程中遇到了实训机会较少,市场容量有限、管理不到位,学生难以“走出去”,实训岗位单一化,实训效果难以考核等各种困境,因此,必须采取行之有效的对策,应用创新的眼光去摸索一种符合实际的实训教学模式,以提高药管专业的实训教学效果。     

黄正色与《辽阳稿》

黄正色为明代官员,嘉靖时期因受人诬陷流放辽东。黄正色在辽东度过了30年的流放生活,在此期间,他教书授徒,培养人才,为辽东的文化建设作出了重要贡献。黄正色的诗,没有愁怨,没有悲情,更多的是平和与乐观,集中表现出其"不以物喜,不以己悲"的家国情怀。     

Exploring adverse drug reactions of diabetes medicine using social media analytics and interactive visualizations

The aim of this study is to propose an automatic and real-time social media analytics framework with interactive data visualizations to support effective exploration of knowledge about adverse drug reaction (ADR) surveillance. This proposed framework has been prototypically implemented on the basis of social media data. A longitudinal diabetes patient online community data (AskaPatient.com) as well as FDA Adverse Event Reporting Systems (FAERS) data as a benchmark were used to evaluate our proposed approach’s performance. Based on the results, our approach significantly increases the precision and accuracy for ADR extraction. The number of ADR cases, the time when the ADRs occurred, and the rating of Glucophage have been visualized that resulted by mining a collection of 870 ADRs posted in Askapatents.com over a certain time period (from 2001 to 2015). The results have important implications for pharmaceutical companies and hospitals wishing to monitor ADRs of medicines.     

School exclusion,substance misuse and use of weapons: an interpretative phenomenological analysis of interviews with children

The study presents data drawn from semi-structured interviews with five young people permanently excluded from schools in North East England. The research aimed to investigate the risk factors that lead to the children using illegal drugs, to determine the drivers and implications for drug misuse and the carrying of knives into school. The research also hoped to elicit from the young people, the solutions that could have prevented their exclusion from school. The interviews were analysed using interpretative phenomenological analysis to understand how a homogenous sample made sense of their lived experiences. The findings highlight the importance of prompt identification and support for children with learning and subsequent mental health needs as the evidence suggests they lead to perceived negative behaviours by teachers. The research provides further evidence that behaviour sanctions in mainstream schools such as detention and isolation booths do not improve behaviour but make it worse. Original to this research is the finding that children are consuming drugs before school to cope with their inability to access the learning, to aid their concentration and to medicate themselves to reduce the likelihood of being sanctioned by teachers.     

利用STN解决药物研发过程中的信息需求

药物研发是一个漫长、复杂、且花费昂贵的科研活动过程,其文献信息支持工作非常关键,并贯穿于药物研发的全过程。利用STN国际联机数据库,可解决药物研发过程中的信息需求。     

水杨酸钠-葡甘聚糖／壳聚糖／聚乙烯醇缓释药膜的研究

采用溶液共混法将水杨酸钠（NaSal）包埋在魔芋葡甘聚糖（KGM）、壳聚糖（CTS）与聚乙烯醇（PVA）共混物中,制备了Nasal—KGM／CTS／PVA缓释药膜．用红外光谱表征了药膜的结构,考察了KGM,CTS与PVA三者的质量比以及NaSal的用量对膜的耐水性、水蒸气透过率的影响,测定了水杨酸钠的释放率．结果表明：当KGM,CTS,PVA的质量比为2：2：1时,制备的缓释药膜具有较好的耐水性和较低的水蒸气透过性能,NaSal的缓释性能良好．     

白藜芦醇/富勒烯纳米组装体的制备——在胆管支架抗炎涂层中的应用评估

采用白藜芦醇(Res)和富勒烯(C60)结合制备Res/C60纳米组装体并验证其安全性和抗炎性。通过扫描电子显微镜(SEM)、拉曼光谱和X射线衍射研究了纳米组装体形貌、粒径大小及波谱峰值特征。其次,通过紫外分光光度法研究了Res的药物缓释行为。最后,通过MTT法在人脐静脉内皮细胞(HUVECs)层面验证了Res/C60纳米组装体的安全性以及体外的抗炎性。研究发现,Res/C60纳米组装体呈短棒状,横截面平均直径为(379.74±33.47)nm。拉曼光谱和X射线衍射特征峰显示Res/C60纳米组装体被成功制备。Res/C60纳米组装体的聚氨酯(PU)涂层中Res药物在30 d内累积释放量可达60%左右。胆管支架涂层对HUVECs细胞毒性较低,且通过释放Res可显著抑制炎症因子的释放。     

色谱法在药物分析中的应用

文中简要阐述了色谱法的起源和原理,并介绍了气相色谱法、液相色谱法包括高效液相色谱法、离子色谱法以及反相高效液相色谱法在药物分析领域的应用研究．     

科研信息化助力合理药物设计新发展

大数据时代,超级计算机促进了合理药物设计研发,这种药物研究模式的转变推动了创新新药发现又一个春天的到来。科研信息化基础设施的升级,包括高性能计算机处理器技术的不断更新,新的资源模式的出现,使得超算技术与计算生物学、计算化学密切结合,进一步为传统的药物发现和计算机辅助药物设计增添了新功能,加速了分子动力学模拟和虚拟筛选等的研究进程。文章从药物设计学方法研究、药代动力学模型设计和药物设计方法的具体应用三个方面对当今合理药物设计领域的新发展进行了评述,详尽阐释了科研信息化在提高效率、降低成本、加快进程、管控风险及提升研发价值和创新能力方面的优势。