False negativity to carbohydrate-deficient transferrin and drugs: a clinical case

Introduction:

In this work we report on the possible effect of the medical therapy on CDT concentration in a chronic alcohol abuser, with known medical history (July 2007 – April 2012) and alcohol abuse confirmed by relatives.

Case history:

At the end of 2007, patient displayed the following laboratory results: AST 137 U/L, ALT 120 U/L, GGT 434 U/L, MCV 101 fL and CDT 3.3%. On December 2007, after double coronary artery bypass surgery, he began a pharmacological treatment with amlodipine, perindopril, atorvastatin, isosorbide mononitrate, carvedilol, ticlopidine and pantoprazole. In the next months, until may 2011, the patient resumed alcohol abuse, as confirmed by relatives; however, CDT values were repeatedly found negative (0.8% and 1.1%) despite elevated transaminases and GGT, concurrent elevated ethyl glucuronide concentration (> 50 mg/L) and blood alcohol concentration (> 1 g/L). Alcohol consumption still continued despite increasing disulfiram doses ordered by an Alcohol Rehab Center. On May 2011, the patient was transferred to a private medical center where he currently lives.

Conclusions:

This study suggests the possibility that a medical therapy including different drugs may hamper the identification of chronic alcohol abusers by CDT.     

Comparison of digoxin concentration in plastic serum tubes with clot activator and heparinized plasma tubes

Introduction:

Sample type recommended by the manufacturer for the digoxin Abbott assay is either serum collected in glass tubes or plasma (sodium heparin, lithium heparin, citrate, EDTA or oxalate as anticoagulant) collected in plastic tubes. In our hospital samples are collected in plastic tubes. Our hypothesis was that the serum sample collected in plastic serum tube can be used interchangeably with plasma sample for measurement of digoxin concentration. Our aim was verification of plastic serum tubes for determination of digoxin concentration.

Materials and methods:

Concentration of digoxin was determined simultaneously in 26 venous blood plasma (plastic Vacuette, LH Lithium heparin) and serum (plastic Vacuette, Z Serum Clot activator; both Greiner Bio-One GmbH, Kremsmünster, Austria) samples, on Abbott AxSYM analyzer using the original Abbott Digoxin III assay (Abbott, Wiesbaden, Germany). Tube comparability was assessed using the Passing Bablok regression and Bland-Altman plot.

Results:

Serum and plasma digoxin concentrations are comparable. Passing Bablok intercept (0.08 [95% CI = −0.10 to 0.20]) and slope (0.99 [95% CI = 0.92 to 1.11]) showed there is no constant or proportional error.

Conclusion:

Blood samples drawn in plastic serum tubes and plastic plasma tubes can be interchangeably used for determination of digoxin concentration.     

新工科背景下通过竞教结合提高交通工程专业人才培养质量研究

近年来,教育部大力推进新工科建设,鼓励高校探索形成领跑全球工程的中国教育模式,促进国家人才培养和强国建设,而学科竞赛的开展正好可以为教学改革及创新人才培养带来积极的促进作用。文章针对交通工程教学环节中存在的问题,结合交通工程专业特点,探索本科课堂教学与学科竞赛相互促进、学科竞赛与实践教学互联互通等多种培养模式,进而形成学科竞赛驱动下的交通工程专业教学改革措施,旨在提高交通工程专业教学质量,培养学生的实践能力、创新能力以及分析解决问题的能力。     

机场管制模拟练习设计方法初探

模拟机训练是空管实践教学最重要的组成部分,是提高空管学员管制技能最重要的手段。本文针对机场管制模拟练习设计,在分析国内外现状的基础上,提出了适应我国空管教学的模拟练习设计方法。     

论如何完善交通事故认定的规则

近年来,随着机动车保有量的不断增长,交通事故与公众的联系日渐密切。而作为交通事故处理的关键环节,交通事故认定存在着规则不清晰、不统一的局面,引发了大量的争议。通过分析可知,交通事故认定实质上是一种行政确认行为,而行政确认是要式行政行为、羁束行政行为的特点,也迫切需要制定完善统一明确的技术规范。交通事故认定规则的完善,需要避免和道路交通行政执法观念重叠,而“险情避让理论”较为符合交通事故形成的客观原理。根据这个理论模型推导,结合法律条文,交通事故认定的基本原则可概括为因果关系原则和过错责任原则。交通事故认定的因果关系原则,指交通事故当事人责任的确定,应该在与交通事故的发生及损害后果有因果关系的行为范围内确定。过错责任原则,指在认定当中,要根据当事人主客观过错的大小,来划分当事人的责任。     

意象对话技术治疗强制隔离戒毒人员抑郁症个案报告

本文是用意象对话技术对一名企图自杀的抑郁症强制隔离戒毒人员进行心理治疗的个案研究。通过积极干预、意象呈现、修改意象、改变或重构意象等技术,鼓励来访者勇敢地面对问题,消除不合理的期望,最终实现生活态度的转变和自我人格的积极成长。     

基于Apriori算法的船舶交通事故关联规则分析

为有效分析船舶交通事故的潜在因果关系,预防和控制事故的发生,采用关联规则方法对相关数据进行有效挖掘,制定船舶交通事故关联规则挖掘流程,建立船舶交通事故关联规则分析模型.基于Apriori算法对船舶交通事故数据进行关联规则分析,挖掘事故间的强关联规则.对所挖掘出的强关联规则进行分析,发现事故致因因素间的潜在关系,并提出事故防范对策以保障海上交通安全.     

一种移动话务的潮汐效应解决方案

本文提出了一种移动话务的潮汐效应智能化解决方案,提出了一种基带资源池技术,以达到提高基站利用率和降低建网成本、降低能耗的目的。     

城市公交车对双车道混合交通流的影响

城市道路上的车流主要是公交车和小汽车混合流,而一般交通流理论都是以小汽车流为对象进行研究和建模。基于运动波理论和线性元胞自动机模型,本文提出了一种宏观与微观空间表现尺度相结合的双车道混合交通流组合建模方法分析。     

高等体育院校校医院药品管理的实践探讨

根据药品管理的理论及法规,结合北京体育大学校医院的特点,探讨了高等体育院校校医院药品管理的特点,认为:药品具有特殊用途,并且是治疗的重要工具之一,药品管理应该把握好购药原则与规划,利用各种手段完善药库管理,把握好不同药品的管理,更好的满足教职员工和学生的医疗需要.