复杂网络在蛋白质折叠中的应用

简述了复杂网络的静态几何量及其机制模型,然后列举了复杂网络在蛋白质研究领域的应用进展．     

"折叠问题"解法探究

阐述折叠问题是重要的几何应用问题，其本质是轴对称；说明解题要利用特殊图形的知识、代数技巧、转化的思想。     

中学生心理折叠能力的发展性及其与智力的相关性研究

中学生心理折叠能力的发展特点及其与智力的相关性有以下几方面:(1)总体而言,中学生的心理折叠能力随年级(或年龄)的增长而提高;(2)一般而言,男性优于女性,但差异不明显;(3)个体心理折叠能力与智力有非常显著的正相关性.     

Medical student retention of embryonic development: Impact of the dimensions added by multimedia tutorials

The purpose of this project was to develop Web‐based learning modules that combine (1) animated 3D graphics; (2) 3D models that a student can manipulate independently; (3) passage of time in embryonic development; and (4) animated 2D graphics, including 2D cross‐sections that represent different “slices” of the embryo, and animate in parallel. These elements were presented in two tutorials, one depicting embryonic folding and the other showing development of the nervous system after neural tube formation. The goal was to enhance the traditional teaching format—lecture combined with printed diagrams, text, and existing computer animations—with customized, guided, Web‐based learning modules that surpassed existing resources. To assess module effectiveness, we compared quiz performance of control groups who attended lecture and did not use a supporting module, with study groups who used a module in addition to attending lecture. We also assessed our students' long‐term retention of the material, comparing classes who had used the module with students from a previous year that had not seen the module. Our data analysis suggests that students who used a module performed better than those given only traditional resources if they used the module after they were already somewhat familiar with the material. The findings suggest that our modules—and possibly computer‐assisted‐instruction modules in general—are more useful if used toward the later stages of learning, rather than as an initial resource. Furthermore, our data suggest that the animation aids in long‐term retention. Both medical students at the University of Cincinnati and medical faculty from across the country commented favorably on their experiences with the embryonic development modules. Anat Sci Ed 1:252–257, 2008. © 2008 American Association of Anatomists.     

几何教学与学生空间想象能力关系的调查研究

几何教育在高职美术专业学生空间想象力发展过程中所起的作用有如下几方面:几何教育与学生空间想象力发展密切相关;几何教育对学生的折叠能力、展开能力和心理旋转能力的发展影响较为显著,但对学生图形识别能力影响较弱;一定的几何知识,几何概念,几何体的性质、空间关系等知识的掌握以及运用正确的解题策略,这4者的有机整合是发展学生空间想象力的有效途径.     

中学数学主题教学的实践探索——以“多面体剪折”课程方案为例

在数学新课程标准提出模块和主题学习的要求下，通过立体几何中“多面体剪折”课程方案的实践与尝试，对中学数学主题教学进行初步探索，并就数学主题教学设计的关键环节以及进一步实践拓展，进行理论思考与研究。     

中学生心理展开能力与心理折叠能力发展的对比研究

对中学生心理展开能力与心理折叠能力发展进行对比研究,发现:(1)从总体上看,中学生的心理展开、心理折叠能力随年级(或年龄)的增长而提高.初一至初二年级两种能力均快速发展,发展速度和发展水平几乎没有差别,从初三开始,心理展开能力快于心理折叠能力的发展;(2)重点中学学生心理展开能力、心理折叠能力无论是在发展速度还是在发展水平上均显著地高于普通中学学生;(3)几何教学对两种认知能力的发展具有明显的影响,但是作用在不同认知水平或不同智商水平的群体上,短期内会出现完全不同的结果.     

Heuristic algorithm for off-lattice protein folding problem

Enlightened by the law of interactions among objects in the physical world, we propose a heuristic algorithm for solving the three-dimensional （3D） off-lattice protein folding problem. Based on a physical model, the problem is converted from a nonlinear constraint-satisfied problem to an unconstrained optimization problem which can be solved by the well-known gradient method. To improve the efficiency of our algorithm, a strategy was introduced to generate initial configuration. Computational results showed that this algorithm could find states with lower energy than previously proposed ground states obtained by nPERM algorithm for all chains with length ranging from 13 to 55.     

分子伴侣及其功能的研究进展

分子伴侣是一类能够协助其它多肽进行正常折叠、组装、转运、降解的蛋白质,并在DNA的复制、转录、细胞信号转导及微管的形成和修复过程中发挥重要作用的蛋白质。