NO对黄曲霉产毒的影响研究

研究了不同浓度NO供体SNP和NO清除剂cPTIO对黄曲霉菌产毒的影响．结果表明：在黄曲霉培养过程中添加SNP能导致黄曲霉菌体内NO量增多,产毒量减少;当添加NO清除剂cPTIO时黄曲霉菌体内NO量降低,产毒量增加．SNP浓度为0．200mmol／L时,黄曲霉产黄曲霉毒素的量为0．87μg／mL,比不添加时降低了16．35μg／mL,而且添加SNP的黄曲霉菌体NO荧光值明显增高．说明NO对黄曲霉产毒有一定的抑制作用．     

Relaxing Design Students’ Sketch Inhibition: Experiences with Theoretical Grounding and Impermanent Media

This article reports about a study developed to understand the effectiveness of instructional strategies to manage sketch inhibition in design students through studio-based pedagogy. Sketch inhibition among students and recent graduates of design programs is a prominent aspect of the prevailing digitization of the design industry and education. While traditional and digital media are ideally complementary tools to facilitate the complex process of designing, studio instructors struggle to effectively integrate both into their students’ conceptions and practices. Primary data sources were ethnographic fieldnotes, semi-structured interviews, and students’ responses to open-ended survey questions. Whiteboards used as an impermanent medium, requests for quantity of sketches, and gentle enforcement of time limits were incorporated into studio practices on the foundation of theoretical grounding. Students understood the purpose and advantages of using hand sketches at strategic moments during the design process. Inhibited students responded to this combination of interventions by relaxing enough to focus on engaging with the relevant design tasks rather than focusing on how best to avoid them. Production of rich records, documenting their projects’ progression, served as supporting evidence that sketching had become a more normal and accepted part of the design process than for previous studio cohorts. The authors suggest more experimentation with these strategies and propose that sketching instructors prioritize and nurture ‘thinking sketches’ over ‘persuasive sketches’ to transfer attention from the representation of design solutions toward the design process and the development of mature design solutions.     

注意力缺损多动障碍的两种评估取向的整合及评估模式的建立

有关注意缺损多动障碍的评估一直存在着生理 -心理学测评和学校心理学的行为评价的不同取向。本文分别介绍了生理 -心理学中对抑制功能的认知加工能力测评的取向和学校心理学中重视适应环境的行为水平的测评取向 ,指出了两种取向的优点和不足。并在整合两个取向的基础上 ,提出了新的评估注意力缺损多动障碍的理论模式。     

递增负荷运动过程中雌性大鼠生殖激素水平的变化特点及其机制

对递增负荷运动过程中及恢复期大鼠HPG轴功能激素水平进行了连续、系统的动态观察。结果表明，在长期持续大负荷训练影响下，HPG轴功能全面受抑，激素水平降低，以低促性腺激素及低性腺类固醇水平为特征；恢复期HPG轴功能呈现逐渐恢复态势。     

第二语言习得中的语言迁移现象筒析

在借鉴语言迁移研究成果的基础上,分析了第二语言习得过程中出现的"前摄干扰"(汉式英语)和"后摄干扰"(夹生汉语)现象,以便认识语言迁移的发展规律,从而促进外语教学工作的开展。     

聚众淫乱不应规定为犯罪

我国刑法把聚众淫乱行为规定为妨害社会秩序的犯罪,但由于这种行为本身所具有的隐蔽性特征,司法实践中作为有罪处理的案件很少。从刑事立法的角度考察,聚众淫乱罪是否具有合理性,是否符合刑法保护法益的目的,是否背离刑法谦抑性的要求,这些都需要法学界予以理性的回答。     

The Dilemma of English Teaching in the EFL Classroom in a Vocational Technical Institute

English teachers are commonly confronted with the dilemma in the EFL classroom. However, Ellis (2009) mentioned that less attention has been paid to this domain. The aim of this paper is to examine sou...     

Pure total flavonoids from Citrus paradisi Macfadyen actmsynergistically with arsenic trioxide in inducingmapoptosis of Kasumi-1 leukemia cells in vitro

To investigate the potential effects of pure total flavonoid compounds (PTFCs) from Citrus paradisi Macfadyen separately or combined with arsenic trioxide on the proliferation of human myeloid leukemia cells and the mechanisms underlying the action of PTFCs. The effects of PTFCs separately or combined with arsenic trioxide on the proliferation and apoptosis of leukemia cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), fluorescence microscopy, and flow cytometry. Their effects on the expression levels of apoptosis-related regulators were determined by Western blot assay. PTFCs combined with arsenic trioxide significantly inhibited the growth of Kasumi-1 cells, and apoptosis was confirmed by flow cytometry analysis. Hoechst 33258 staining showed more significant morphological changes and more apoptosis following the combined treatment. Western blots showed changes in the expression of genes for poly ADP-ribose polymerase (PARP), caspase 3/9, and P65. The results indicated that PTFCs separately or combined with arsenic trioxide inhibited proliferation of leukemia cells in vitro and induced their apoptosis by modulating the expression of apoptosis-related regulator genes.     

土酸介质中锌单组分缓蚀剂的筛选

选取了数十种化合物,用失重法分别对其在土酸溶液中对锌的缓蚀性能进行了研究,结果发现在土酸介质中对锌起缓蚀作用的化合物主要是季铵盐类(苯扎溴胺、十六烷基三甲基溴化铵)、杂环化合物(溴代十六烷基吡啶)和含硫化合物(十二烷基磺酸钠)等。     

黄芩苷对小鼠抗炎作用的研究

昆明种小鼠100只随机均分10组：分别为口服和腹腔注射黄芩苷制剂大（2．0g／kg）、中（1．og／kg）、小（0．5g／kg）剂量组、阳性对照组（口服和腹腔注射地塞米松注射液0．01g／kg）和空白对照组（口服和腹腔注射等量生理盐水）,每天给药1次,连续给药7d,最后一次给药后30min,用二甲苯致小鼠耳廓肿胀,致炎1h后颈椎脱臼致死,冲下左右两耳片分别称重,测定小鼠耳廓的肿胀率和肿胀抑制率。结果：与生理盐水对照组比较,口服黄芩苷大剂量组小鼠耳廓的肿胀率显著降低（P〈0．01）;腹腔注射黄芩苷大剂量组小鼠耳廓肿胀率显著降低（P〈0．01）,中、小剂量组肿胀率降低（P〈0．05）。表明黄芩苷口服或腹腔注射对小鼠均具有一定的抗炎作用,呈现量效关系,且腹腔注射抗炎效果强于口服。