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51.
Yildirim K Uzkeser H Keles M Karatay S Kiziltunc A Kaya MD Yildirim A 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):109-113
Introduction:
The aim of this study was to investigate whether serum levels of interleukin-1β (IL–1β) has any possible correlation on inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen concentration in patients with familial Mediterranean fever (FMF) patients during attack-free period.Materials and methods:
The serum levels of IL-1β, as an indicator of cytokines status, and the acute phase response proteins, CRP, ESR and fibrinogen levels were evaluated in 35 attack-free patients with FMF and 25 healthy volunteers.Results:
Serum IL-1β levels were significantly higher in patients with FMF than control subjects (P = 0.018). There was no statistically significant difference in the serum levels of ESR, CRP and fibrinogen between two groups (P = 0.181, P = 0.816, P = 0.686, respectively). There was a significant correlation between IL-1β and CRP (r = 0.513, P = 0.002) values of FMF group.Conclusions:
In conclusion, our results confirm the presence of increased IL-1β levels in FMF patients during attack-free period. Serum IL-1β values seems to correlate with CRP levels. The elevation of IL-1β levels may be important in monitoring subclinical inflammation of attack free period in FMF patients. 相似文献52.
Joseph Henson Charlotte L. Edwardson Danielle H. Bodicoat Kishan Bakrania Melanie J. Davies Kamlesh Khunti 《Journal of sports sciences》2018,36(14):1586-1593
Although high levels of sitting time are adversely related to health, it is unclear whether moving from sitting to standing provides a sufficient stimulus to elicit benefits upon markers of chronic low-grade inflammation in a population at high risk of type 2 diabetes (T2DM). Three hundred and seventy two participants (age = 66.8 ± 7.5years; body mass index (BMI) = 31.7 ± 5.5kg/m2; Male = 61%) were included. Sitting, standing and stepping was determined using the activPAL3TM device. Linear regression modelling employing an isotemporal substitution approach was used to quantify the association of theoretically substituting 60 minutes of sitting per day for standing or stepping on interleukin-6 (IL-6), C-reactive protein (CRP) and leptin. Reallocating 60 minutes of sitting time per day for standing was associated with a ?4% (95% CI ?7%, ?1%) reduction in IL-6 (p = 0.048). Reallocating 60 minutes of sitting time for light stepping was also associated with lower IL-6 levels (?28% (?46%, ?4%; p = 0.025)). Substituting sitting for moderate-to-vigorous (MVPA) stepping was associated with lower CRP (?41% (?75%, ?8%; p = 0.032)), leptin (?24% (?34%, ?12%; p ≤ 0.001)) and IL-6 (?16% (?28%, 10%; p = 0.036). Theoretically replacing 60 minutes of sitting per day with an equal amount of either standing or stepping yields beneficial associations upon markers of chronic-low grade inflammation. 相似文献
53.
Sweta T. Kothari Ranjana A. Deshmukh 《Indian journal of clinical biochemistry : IJCB》2006,21(1):15-26
Cytokines, viral load and opportunistic infections play an important role in HIV-disease progression. Hundred children vertically
infected with HIV were enrolled to determine mRNA levels of TNF-α, IL-10, IL-4 and IFN-γ. These levels were estimated by amplifying
cytokine mRNA from peripheral blood mononuclear cells. Severity of HIV was staged by the reduction in CD4
+ T cells and the onset of opportunistic infections. IL-10 mRNA levels were observed to increase with the severity. Despite
the rising IL-10 mRNA levels, TNF-α mRNA levels increased with severity of HIV and decrease in CD4
+ T cell counts. IL-4 mRNA levels increased with the reduction in CD4
+ T cell numbers. Depleting mRNA levels of IFN-γ contributed to the worsening of HIV disease. Increase in TNF-α and IL-4 levels
appended to the disease severity by upregulation of the viral replication. Increased IL-10 levels and decreased IFN-γ levels
predisposed the children to HIV associated opportunistic infections, which in return contributed to cytokine disarray. 相似文献
54.
Pathogens, especially Gram-negative bacteria or bacterial endotoxin, along with other classical factors, may be involved in
inflammatory response within the aortic endothelium during the progression of cardiovascular disease. Studies have shown that
bacterial endotoxin activates various inflammatory processes in the body. Our study aims to establish a correlation between
endotoxemia and vascular expression of antioxidant enzymes. Swiss albino mice (4 weeks old) were fed a high fat diet for 24
weeks and then were administered Escherichia coli endotoxin intraperitonealy, for 4 weeks. Tissue antioxidant enzymes, serum
levels of IL-6 and TNF alpha were measured from the mice. We report that i.p. administration of endotoxin to hyperlipidemic
mice resulted in elevation of superoxide dismutase and catalase enzymes, which was paralleled by a systemic reduction of serum
cholesterol and LDL expression. Myeloperoxidase levels were also found to be elevated in aortic tissue, while an increase
was also observed in the serum cytokine levels. 相似文献
55.
Emil List Larsen Henrik Enghusen Poulsen Cristina Michaelsen Laura Kofoed Kjær Mark Lyngbæk Emilie Skytte Andersen 《Journal of sports sciences》2020,38(18):2080-2091
ABSTRACT
Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2?-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95% CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95%CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. 相似文献
56.
57.
《European Journal of Sport Science》2013,13(1):3-14
Abstract Both carbohydrate depletion and dehydration have been shown to decrease performance whilst severe dehydration can also cause adverse health effects. Therefore carbohydrate and fluid requirements are increased with exercise. Ingestion of 200–300?g of CHO 3–4?h prior to exercise is an effective strategy in order to meet daily CHO demands and increase CHO availability during the subsequent exercise period. There is little evidence that CHO during the hour immediately prior to exercise has adverse effects such as rebound hypoglycaemia. CHO ingestion during exercise has been shown to improve performance as measured by enhanced work output or decreased exercise time to complete a fixed amount of work. Recent studies have demonstrated that exogenous CHO oxidation rates can be increased by ingesting combinations of CHO that use different intestinal CHO transporters. After exercise maximal muscle glycogen re-synthesis rates can be achieved by ingesting CHO at a rate of ~1.2?g/kg/h, in relatively frequent (e.g., 15–30?min) intervals for up to 5?h following exercise. Protein amino acid mixtures may increase glycogen synthesis further but only if relatively small amounts of CHO are ingested. Hypohydration and hyperthermia alone have negative effects on performance but their combination is particularly serious, both in terms of performance and health. Dehydration can be prevented by fluid ingestion pre exercise and during exercise. Because of large individual differences it is difficult to individualise the advice. Perhaps the best guidance for athletes is to weigh themselves to assess fluid losses during training and racing and limit weight losses to 1% during exercise lasting longer than 1.5?h. Excessive fluid intake has been associated with hyponatremia. Post exercise the volume of fluid ingested and sodium intake are important determinants of rehydration. 相似文献
58.
《European Journal of Sport Science》2013,13(3):52-66
This review will examine the effects of exercise and training on immune func-tion and will discuss the methodological problems that limit the interpretation of many exercise immunology studies. Acute bouts of exercise cause a tempo-rary depression of various aspects of immune function, such as neutrophil oxidative burst, lymphocyte proliferation, monocyte MHC class II expression, and natural killer cell cytotoxic activity, that will usually last for approximately three to 24 hours after exercise, depending on the intensity and duration of the exercise bout. Post-exercise immune function depression is most pronounced when the exercise is continuous, prolonged (<1.5 hours), of moderate to high intensity (55-75% VO2max), and performed without food intake. Periods of intensified training that result in overreaching have been shown to chronically depress immune function—i.e., immune cell functions measured at rest are still depressed 24 hours after the last exercise bout. Although elite athletes are not clinically immune deficient, it is possible that the combined effects of small changes in several immune parameters may compromise resistance to common minor illnesses such as upper respiratory tract infection. Protracted immune depression linked with prolonged training may determine susceptibility to infection, particularly at times of major competitions. 相似文献
59.
Abstract Exercise for individuals with multiple sclerosis (MS) has been shown to improve cardiovascular function, increase strength and endurance, and reduce fatigue. The impact of exercise on immune function in the disease, however, remains mostly unexplored. Ten female MS patients participated in an 8 week programme of twice-weekly progressive resistance training, with pre- and post-training assessment of serum concentrations of cytokines IL-2, IL-4, IL-6, IL-10, CRP, TNF-α and IFN-γ. After training, IL-4, IL-10, CRP and IFN-γ showed statistically reduced resting concentrations in blood, while TNF-α showed non-significant reductions and IL-2 and IL-6 remained unchanged. These results suggest that progressive resistance training may have an impact on cytokine concentrations in individuals with MS and should be confirmed in studies with stronger statistical power. The impact of these changes on overall immune function in MS and on disease status and prognosis remains to be determined. 相似文献
60.
Stanislava Petrovic Natasa Bogavac-Stanojevic Jelena Kotur-Stevuljevic Amira Peco-Antic Ivana Ivanisevic Jasmina Ivanisevic Dusan Paripovic Zorana Jelic-Ivanovic 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(2):266-272