信息共享空间研究的知识图谱分析

以CSSCI数据库收录的以信息共享空间为主题的论文为基础数据,通过Citespace3.8R1软件对相关引文数据和主题词数据进行处理,绘制出信息共享空间领域的知识图谱,并对其进行分析,得出我国信息共享空间领域的重要学术文献及学术代表人物、主要研究热点及研究前沿等。     

AR阻断剂对运动骨骼肌ERK1/2信号通路的影响

目的:通过阻断AR,以探讨雄激素对运动骨骼肌ERK1/2通路的影响特点。方法:7周龄雄性SD大鼠30只,随机分为对照组、AR阻断剂组、运动组、AR阻断剂运动组、假手术组。AR阻断剂组于颈部皮下包埋氟他胺释缓剂,运动组进行10 d中等强度运动,于末次运动后6 h取趾长伸肌进行指标测定。结果:与对照组相比,AR阻断剂组趾长伸肌湿重、肌纤维横截面积、AR mRNA及p-ARSer210均显著下降(p<0.01-0.05),MEK1/2、ERK1/2、P90RSK的mRNA及蛋白磷酸化水平未有显著变化。运动组AR及ERK1/2通路的mRNA及蛋白磷酸化水平则显著增加(p<0.05),而其趾长伸肌湿重、肌纤维横截面积并未有显著变化。AR阻断剂运动组各指标与运动组相比均显著下降(p<0.01-0.05),而与AR阻断剂组相比均未有显著变化。结论:阻断AR可显著抑制运动骨骼肌湿重、横截面积及AR的基因和磷酸化表达,证实雄激素对运动骨骼肌的促蛋白合成作用主要经AR介导;AR阻断剂可显著抑制运动骨骼肌ERK1/2通路激活,提示雄激素经AR介导发挥非基因作用。该研究对雄激素促进运动骨骼肌蛋白合成的非基因作用提供一定实验依据。     

CRP,but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Objective

The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy.

Methods

The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m². Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m².

Results

In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced.

Conclusion

The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.

     

基于多变量优化MGM(1,n)模型的郑州市用水量预测

用水量是城市发展水平的重要评价指数。鉴于用水量系统复杂性和非线性的特征,结合郑州市居民用水量的历史数据,通过建立优化背景值的MGM(1,n)模型,实例预测郑州市2008至2015年用水量需求并指出城市居民用水量发展趋势。     

Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells

Due to their toxicity, the increased distribution of microcystins (MCs) has become an important worldwide problem. MCs have been recognized as inhibitors of protein phosphatase 2A (PP2A) through their binding to the PP2A catalytic subunit. However, the exact mechanism of MC toxicity has not been elucidated, especially concerning the cellular response and its autoregulation. To further dissect the role of PP2A in MC-induced toxicity, the present study was undertaken to determine the response of PP2A in human amniotic epithelial (FL) cells treated with microcystin-LR (MCLR), one of the MC congeners. The results show that a low-dose treatment of MCLR in FL cells for 6 h induced an increase in PP2A activity, and a high-dose treatment of MCLR for 24 h decreased the activity of PP2A, as expected. The increased mRNA and protein levels of the PP2A C subunit may explain the increased activity of PP2A. Furthermore, MCLR altered microtubule post-translational modifications through PP2A. These results further clarify the underlying mechanism how MCLR affects PP2A and may be helpful for elucidating the complex toxicity of MCLR.     

Preparation of glucosamine by hydrolysis of chitosan with commercial α-amylase and glucoamylase

Objective  

In order to overcome the defects of chemical hydrolysis approach to prepare glucosamine, an enzymatic hydrolysis method was developed.     

Sm_(1-x)Zn_xFeO_3半导体材料的制备和气敏性能研究

用化学共沉淀法制备了Sm1-xZnxFeO3(0≤x≤0.10)半导体气敏材料。对其固相组成、导电行为和气敏性能进行了研究。结果表明:该系列粉体为正交晶系钙钛矿型结构;6%Zn掺杂SmFeO3导电优于纯相;在160℃工作温度下,6%Zn掺杂微粉制作的元件对0.1%丙酮的灵敏度高达568,是相同工作条件下纯相SmFeO3元件的8.5倍,响应-恢复时间分别为4S,和4min。     

特殊职业技术教育对赫哲鱼皮文化传承的研究

在特教学校结合职业技术教育,探讨了赫哲鱼皮文化的学习和传承。通过特教学校设为校本课程,进行了赫哲鱼皮画技艺的理论教学和实践教学,研究了传承赫哲鱼皮文化的"1+2+3"模式,论述了在文化知识、制作工艺、操作技术、艺术品质方面的传承内涵,总结了几年来的教学经验和特教职教启示,展望了赫哲鱼皮文化发展远景。     

0-1整数规划最优模型在物品设计中的应用

以储药柜的设计为例介绍了0-1整数规划数学模型在物品设计方面的应用。药房内的盒装药品种类繁多,药盒尺寸规格差异较大,一般的储药柜为横纵向等距的设计方案,药盒与两侧竖向隔板之间的间隙会造成宽度冗余,药盒与上面隔板的间隙会造成高度冗余。增加竖向隔板的间距类型数量可以有效地减少宽度冗余,但会增加储药柜的加工成本,同时降低了储药槽的适用范围。研究确定储药柜横纵向隔板间距的类型数量,使得储药柜的总平面冗余量尽可能地小,对现实中储药柜的设计具有重要的指导意义。     

语义翻译和交际翻译视角下《红楼梦》中诗歌英译探析

该文从语义翻译和交际翻译的维度对《红楼梦》中的诗歌英译进行分析,探究两个英译本所采用的翻译策略,从而为翻译教学中诗歌的翻译提供借鉴意义以及为翻译实践提供理论支撑与实践依据。