初中数学解题中侧向思维的有效应用

提高学生的解题能力是初中数学教学的重点。初中数学习题灵活多变,解题方法多种多样,为促进学生解题能力更好地提升,教师会为学生讲解相关的解题思维。其中侧向思维是一种迂回思维,既能帮助学生更好地破题,又能简化解题步骤,提高解题效率,因此,教学中应结合具体例题,为学生讲解侧向思维的具体应用,给其以后的解题带来良好的指引。     

侧面波的研究

当球面声波由介质1进入介质2时,如果波速c1相似文献   

宝兴大厦地震反应分析

文章采用SATWEI和ETABS等软件对宝兴大厦进行内力分析,获得有价值的地震响应参数,从而了解扭转效应,即对于部分框支剪力墙结构,当转换层层高较大时,转换层以上结构抗侧刚度由最大层间位移角控制。     

2008年欧洲杯足球赛横、回传球应用研究

对2008年欧洲杯各参赛队在比赛中使用横、回传球情况进行研究和分析,探索它在对掌握控球权、控制比赛节奏,在进攻时避开对方的紧逼围抢、吸引对方在后场尤其是罚球区附近采用多人、多层次的密集防守力量,在防守时延缓、瓦解对方凌厉攻势,最大限度地减轻后防压力等方面所具有的价值,为更好地进攻打下一定的坚实基础,从而为我国足球教学训练和指导比赛提供一定的参考依据。     

Input associativity underlies fear memory renewal

Synaptic associativity, a feature of Hebbian plasticity wherein coactivation of two inputs onto the same neuron produces synergistic actions on postsynaptic activity, is a primary cellular correlate of associative learning. However, whether and how synaptic associativity are implemented into context-dependent relapse of extinguished memory (i.e. fear renewal) is unknown. Here, using an auditory fear conditioning paradigm in mice, we show that fear renewal is determined by the associativity between convergent inputs from the auditory cortex (ACx) and ventral hippocampus (vHPC) onto the lateral amygdala (LA) that reactivate ensembles engaged during learning. Fear renewal enhances synaptic strengths of both ACx to LA and the previously unknown vHPC to LA monosynaptic inputs. While inactivating either of the afferents abolishes fear renewal, optogenetic activation of their input associativity in the LA recapitulates fear renewal. Thus, input associativity underlies fear memory renewal.     

网球运动对男性青少年骨密度的影响

采用美国Hologic QDR4500型双能X线吸收仪对广州市46名男性学生进行测量,结果：运动组与对照组全身BMC、BMD无显著性差异（P〉0.05）,运动组优势侧BMC高于非优势侧22.4%,高于对照组优势侧8.7%,而运动组优势侧BMD高于非优势侧9.8%,高于对照组优势侧6.0%,运动组下肢BMD高于对照组,但无统计学意义。结论：长期规律网球运动对男性青少年全身骨密度的影响较小,长期规律网球运动对上肢骨密度的影响显著大于下肢。     

Assessment of causal effects of physical activity on neurodegenerative diseases: A Mendelian randomization study

BackgroundPhysical activity has been hypothesized to play a protective role in neurodegenerative diseases. However, effect estimates previously derived from observational studies were prone to confounding or reverse causation.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to explore the causal association of accelerometer-measured physical activity with 3 common neurodegenerative diseases: Alzheimer''s disease (AD), Parkinson''s disease (PD), and amyotrophic lateral sclerosis (ALS). We selected genetic instrumental variants reaching genome-wide significance (p < 5 × 10⁻⁸) from 2 largest meta-analyses of about 91,100 UK Biobank participants. Summary statistics for AD, PD, and ALS were retrieved from the up-to-date studies in European ancestry led by the international consortia. The random-effect, inverse-variance weighted MR was employed as the primary method, while MR pleiotropy residual sum and outlier (MR-PRESSO), weighted median, and MR-Egger were implemented as sensitivity tests. All statistical analyses were performed using the R programming language (Version 3.6.1; R Foundation for Statistical Computing, Vienna, Austria).ResultsPrimary MR analysis and replication analysis utilized 5 and 8 instrumental variables, which explained 0.2% and 0.4% variance in physical activity, respectively. In each set, one variant at 17q21 was significantly associated with PD, and MR sensitivity analyses indicated them it as an outlier and source of heterogeneity and pleiotropy. Primary results with the removal of outlier variants suggested odds ratios (ORs) of neurodegenerative diseases per unit increase in objectively measured physical activity were 1.52 for AD (95% confidence interval (95%CI): 0.88–2.63, p = 0.13) and 3.35 for PD (95%CI: 1.32–8.48, p = 0.01), while inconsistent results were shown in the replication set for AD (OR = 1.06, 95%CI: 1.01–1.12, p = 0.02) and PD (OR = 0.99, 95%CI: 0.88–0.12, p = 0.97). Similarly, the beneficial effect of physical activity on ALS (OR = 0.51, 95%CI: 0.29–0.91, p = 0.02) was not confirmed in the replication analysis (OR = 0.96, 95%CI: 0.91–1.02, p = 0.22).ConclusionGenetically predicted physical activity was not robustly associated with risk of neurodegenerative disorders. Triangulating evidence across other studies is necessary in order to elucidate whether enhancing physical activity is an effective approach in preventing the onset of AD, PD, or ALS.     

运动通过改善PD模型小鼠纹状体D2MSN-D1MSN侧抑制效应调节基底神经节信息输出

目的:通过研究运动及多巴胺II型受体(dopamine type II receptor,D2R)激动剂干预对PD模型小鼠纹状体D2MSN-D1MSN侧抑制效应的影响,揭示运动在改善PD小鼠基底神经节信息输出中的作用及机制。方法:选用4周龄雄性D2-Cre小鼠,右侧纹状体注射兴奋性光敏感蛋白病毒(rAAV-Ef1α-DIO-ChR2-EYFP-WPRE-pA),通过光遗传技术精准操控D2MSN。小鼠随机分为对照组(D2-Cre)和模型组,纹状体分别注射生理盐水和神经毒素6-羟基多巴胺(6-Hydroxydopamine hydrobromide,6-OHDA),经鉴定符合PD标准的模型组小鼠再分为PD组(PDD2-Cre)和PD运动组(PD+Ex D2-Cre)。采用4周匀速跑台运动(18 m/min,40 min/天,连续5天/周)和D2R激动剂分别对各组小鼠进行干预。实验结束后,制备离体脑片,利用全细胞膜片钳结合光遗传技术检测各组小鼠纹状体D2MSN-D1MSN侧抑制效应及黑质网状部的信息输出,并验证侧抑制效应的变化是否由D2R介导。结果:光刺激D2-MSN后,D1-MSN动作电位发放个数PDD2-Cre组显著低于D2-Cre组(P<0.05);PD+ExD2-Cre组显著高于PDD2-Cre组,但仍低于D2-Cre组(P<0.05)。光刺激D2-MSN诱发D1-MSN抑制性突触后电流(Optogenetic stimulation evoked inhibitory postsynaptic currents,oIPSC)的幅值与基线比值,PDD2-Cre组显著高于D2-Cre组(P<0.05),PD+ExD2-Cre组显著低于PDD2-Cre组,但高于D2-Cre组(P<0.05);光刺激D2-MSN诱发黑质网状部(SNr)抑制性突触后场电位(field inhibitory post synaptic potential,fIPSP)最大幅值,PDD2-Cre组显著低于D2-Cre组(P<0.05),PD+ExD2-Cre组显著高于PDD2-Cre组,但低于D2-Cre组(P<0.05)。结论:PD模型小鼠纹状体D2MSN-D1MSN侧抑制效应异常,并影响了SNr的信息输出,这可能是导致PD基底神经节功能紊乱的重要原因之一。4周运动干预通过改善PD模型小鼠纹状体D2MSN-D1MSN侧抑制效应,调节了SNr的信息输出。D2R在运动改善PD小鼠纹状体D2MSN-D1MSN侧抑制效应和调节基底神经节信息输出中起重要作用。     

重载铁路桥墩运营性能研究

重载铁路运输线中桥墩类型多为圆柱型、圆端型以及矩形板型,随着重载铁路运输干线列车轴重以及载运量的增加,给桥墩也带来了许多不利影响,如横向振幅过大、振动加剧等,严重影响了线路运营安全。以圆柱型和圆端型桥墩为研究对象,通过理论计算并结合朔黄铁路多座桥梁运营性能试验,对两种类型桥墩横向振动特性进行了系统研究。     

High-order lateral buckling analysis of submarine pipeline under thermal stress

It is of importance to study and predict the possible buckling of submarine pipeline under thermal stress in pipeline design.Since soil resistance is not strong enough to restrain the large deformation of pipeline,high-order buckling modes occur very easily.Analytical solutions to high-order buckling modes were obtained in this paper.The relationships between buckling temperature and the amplitude or the wavelength of buckling modes were established.Analytical solutions were obtained to predict the occurrence and consequence of in-service buckling of a heated pipeline in an oil field.The effects of temperature difference and properties of subsoil on buckling modes were investigated.The results show that buckling will occur once temperature difference exceeds safe temperature;high-order pipeline buckling occurs very easily;the larger the friction coefficients are,the safer the submarine pipeline will be.