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目的:研究与丙型肝炎病毒(HCV)基因RNA序列同源的人染色体外环状DNA(eccDNA)序列.创新点:首次从HCV阴性者eccDNA中检测到HCV 5’-非编码区(5’-NCR)基因组RNA序列,验证了我们的假设: HCV同源DNA序列存在于人的外周血单核细胞的eccDNA组分中.方法:用分离的eccDNA进行HCV特异的聚合酶链反应(PCR),采用核苷酸序列同源性搜索分析软件(BLASTn)对测序结果进行比对分析,并检测其甲基化模式.结论:实验结果证实了我们的假设:即部分HCV 5’-NCR基因组RNA序列存在于外周血单核细胞的eccDNA组分.同时,甲基化分析结果显示了个体间的甲基化模式所代表的受遗传调控的表观遗传特征. 相似文献
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蔡从中 《重庆大学学报(英文版)》2003,2(1)
1. Introduction Experimental studies have shown that a DNA molecule with alternating pyrimidine-purine sequence can adopt a left-handed, double-helical Z-DNA conformation [1,2]. Such structural changes of DNA occur as a consequence of environmental conditions such as at salt concentration above 4 mol/L NaCl [1,2] or through certain chemical modification such as methylation [1] or bromination [2,3] of bases at physiological conditions. These structural changes and chemical modifications … 相似文献
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Hong-xing Li Lei Xiao Cheng Wang Jia-li Gao Yong-gong Zhai 《Journal of Zhejiang University. Science. B》2010,11(10):784-791
It is generally agreed that adipocytes originate from mesenchymal stem cells in what can be divided into two processes: determination
and differentiation. In the past decade, many factors associated with epigenetic signals have been proved to be pivotal for
the appropriate timing of adipogenesis progression. A large number of coregulators at critical gene promoters set up specific
patterns of DNA methylation, histone acetylation and methylation, and nucleosome rearrangement, that act as an epigenetic
code to modulate the correct progress of adipocyte differentiation and adipogenesis during adipogenesis. In this review, we
focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis. 相似文献