冠心病患者血浆同型半胱氨酸变化及叶酸的干预治疗

目的 了解血浆同型半胱氨酸(Homocysteine，Hcy)、叶酸和维生素(Vit)B12水平与冠心病的关系；观察叶酸干预治疗高Hcy血症的疗效．方法 经冠脉造影确诊的冠心病患者97例、亚冠心病患者58例及完全正常3l例，用高效液相色谱法测血浆Hcy水平，用放免法测血浆叶酸和VitB12浓度．其中高Hcy血症病人每天服用叶酸5mg，观察4周和8周后血浆Hcy水平变化．结果 冠心病和亚冠心病患者血浆Hcy水平明显高于正常人，叶酸和VitB12水平则明显下降；冠心病患者冠脉病变支数越多，血浆Hcy升高和叶酸、VitB12下降越明显；叶酸治疗高Hcy血症患者4周和8周，分别使血浆Hcy水平下降12．5％和38．5％．结论 冠心病和亚冠心病患者血浆Hcy水平明显升高，高Hcy血症是冠心病的危险因素之一．血浆Hcy水平变化与冠脉病变程度正相关．叶酸干预治疗可使高Hcy血症患者血浆Hcy浓度明显降低．     

元胡新品种选育

对采用大田单株法筛选出的元胡大叶型和小叶型两个品种的植株性状、抗病性、品质和产量进行了比较，结果表明，大叶型元胡是一个较为理想的品种类型，其产量可比目前大田种植的农家品种提高１０％左右。     

海水鱼“白点”病引起的宿主脏器组织化学变化

本文通过对海水硬骨鱼的3种主要脏器的组织化学染色实验，研究了海水鱼“白点”病时宿主非寄生部位细胞中的糖原、蛋白质、AKP酸及线粒体含量和活性的影响；分析了组织化学变化与宿主体症的关系     

Understanding Virtual Epidemics: Children’s Folk Conceptions of a Computer Virus

Our work investigates the annual outbreak of Whypox, a virtual epidemic in Whyville.net, a virtual world with over 1.2 million registered players ages 8–16. We examined online and classroom participants’ understanding of a computer virus using surveys and design activities. Our analyses reveal that students have a mostly na?ve understanding of a computer virus influenced by mythological or anthropomorphic perspectives; only few were able to describe computational elements. The 35 students who participated in a curricular intervention in addition to the virtual epidemic shared these na?ve conceptions initially, but developed more sophisticated views after the intervention. The discussion addresses possible explanations for students’ conceptions and implications for future instructional designs.     

高速公路病害防治和水泥路面建造保养措施

通过对公路工程质量通病的病害分析和防治措施,包括软土地基处理与路基沉陷防治、路基稳定与病害防治、混凝土路面病害与防治,需加强水泥混凝土路面病害防治,提高水泥混凝土路面养护水平与质量标准。     

PBL联合CBL教学模式在动物外产科疾病教学中的应用

动物外产科疾病是动物医学及其相关专业的一门重要的职业技术课程,传统的教学方式是先理论、后实践,以教师讲解为主,缺乏学生讨论和回答问题环节,学生对学习的目的和意义不明确,对所学内容印象不深,难以和临床实际联系起来。将案例教学法（CBL）和以问题为基础的教学法（PBL）联合应用于动物外产科疾病教学中,既可培养学生独立思考、分析和解决问题的临床思维能力,又可激发学生学习的积极性,从而提高动物外产科疾病课程的教学质量。     

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese,non-hypertensive,and non-diabetic young and middle-aged Chinese population

Background and objective: Non-alcoholic fatty liver disease (NAFLD) is associated with arterial stiffness in the general population. Age, obesity, hypertension, and diabetics are risk factors for arterial stiffness. In this study, we aimed to investigate the association between NAFLD and arterial stiffness as measured by brachial-ankle pulse wave velocity (baPWV) in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population. Methods: A cross-sectional study with 1296 non-obese, non-hypertensive, and non-diabetic young and middle-aged (20–65 years) subjects undergoing routine medical check-ups in the International Health Care Center of the Second Affiliated Hospital of School of Medicine of Zhejiang University was carried out. Fatty liver was diagnosed by ultrasonography, and baPWV was measured using an automatic waveform analyzer. The subjects were classified into two groups according to the presence of NAFLD, and divided into a further two groups according to their baPWV. Results: The overall incidence of NAFLD was 19.0%, and NAFLD patients had a significantly higher level of baPWV than the controls ((1321±158) cm/s vs. (1244±154) cm/s; P<0.001). The incidence of NAFLD was clearly higher in the increased baPWV group than in the normal baPWV group (29.3% vs. 16.9%; P<0.001), and the incidence increased in line with the increase of baPWV quartiles in the normal range as well as with the severity of arterial stiffness (both P for trend <0.001). Multiple linear logistic regression analysis showed that the presence of NAFLD was positively and independently associated with baPWV. Conclusions: Our results suggest that the presence of NAFLD is associated with arterial stiffness as measured by baPWV in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population.     

Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis简

Objective

Many investigations have studied the associations between matrix metalloproteinase-9 (MMP-9) C1562T polymorphisms and coronary artery disease (CAD). However, the conclusions of these studies were inconsistent. Therefore, this study was aimed at clarifying the association between MMP-9 C1562T polymorphisms and CAD in a large-scale meta-analysis.

Methods

The PubMed and Embase databases were retrieved to collect all publications on the association between MMP-9 C1562T polymorphisms and CAD. Then the odd ratios (ORs) and 95% confidence intervals (95% CIs) for C1562T TT+TC versus CC genotype between CAD and the control groups were evaluated. Subgroup analysis was also performed according to different races. The meta-analysis was performed by Stata 10.0.

Results

Sixteen case-control studies were included in our meta-analysis, involving 11 032 CAD patients and 4628 non-CAD controls. Compared with C allele carriers, East Asian T allele carriers TT+TC had a significantly higher risk of CAD (OR=1.43; 95% CI: 1.03–1.99; P=0.031); however, there were no significant associations in Western populations (OR=1.06; 95% CI: 0.96–1.18; P=0.240) or West Asians (OR=1.13; 95% CI: 0.75–1.70; P=0.565). When further analyzing the association between C1562T polymorphisms and myocardial infarction (MI, the most serious type of CAD), the risk of TT+TC genotype versus CC genotype for MI was significantly higher for the overall (OR=1.21; 95% CI: 1.04–1.40; P=0.012) and for East Asians (OR=1.58; 95% CI: 1.26–1.97; P=0.000) but not in Western populations (OR=1.12; 95% CI: 0.99–1.26; P=0.078).

Conclusions

Our meta-analysis suggested an obvious ethnic difference in the association between MMP-9 C1562T polymorphisms and CAD. MMP-9 C1562T polymorphism was significantly related to CAD in East Asians. However, no significant associations were observed in either West Asians or Western populations.     

先天性心脏病患儿的整体护理

研究目的：关于先天性心脏病患儿的整体护理。研究方法：对先天性心脏病患儿的药物护理、心理关怀、外科手术及家庭健康指导。研究原因：现如今许多的先天性心脏病患儿没有得到更好更有效的护理,影响着先天性心脏病患儿的患后健康,对先天性心脏病患儿的自身成长不利。研究结果：得到先天性心脏病患儿的整体护理的情况。     

口腔牙椅冷光灯刺眼问题与解决方法的调查报告

目的:调查了解口腔疾病患者对治疗中牙椅冷灯光刺眼程度的感受及运用牙椅光源遮挡板解决后的不同看法。方法:通过问卷对150例我市不同诊所的口腔疾病治疗患者进行调查,以期从多个方面反映不同年龄段及不同职业的人对冷光灯灯光刺眼程度的感受及对应用牙椅光源遮挡板来解决该问题的看法。结果:大部分的被调查者感受到治疗过程中灯光强烈刺眼并意识到这对眼睛有所损害,与此同时他们认为牙椅光源遮挡板对这一问题的解决可以起到良好的作用,应用效果值得肯定。结论:可以将牙椅光源遮挡板应用于临床治疗当中来解决冷光灯灯光刺眼的问题。