What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor?

This article is to summarize the molecular and functional analysis of the gene “suppression of tumorigenicity 13” (ST13). ST13 is in fact the gene encoding Hsp70 interacting protein (Hip), a co-factor (co-chaperone) of the 70-kDa heat shock proteins (Hsc/Hsp70). By collaborating with other positive co-factors such as Hsp40 and the Hsp70-Hsp90 organizing protein (Hop), or competing with negative co-factors such as Bcl2-associated athanogen 1 (Bag1), Hip facilitates may facilitate the chaperone function of Hsc/Hsp70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and regulators of proliferation or apoptosis. Although the nomenclature of ST13 implies a role in the suppression of tumorigenicity (ST), to date available experimental data are not sufficient to support its role in cancer development, except for the possible down-regulation of ST13 in gastric and colorectal cancers. Further investigation of this gene at the physiological level would benefit our understanding of diseases such as endocrinological disorders, cancer, and neurodegeneration commonly associated with protein misfolding.     

Assignment of <Emphasis Type="Italic">CCR7</Emphasis> gene to chicken chromosome 27 by radiation hybrid panel mapping

The protein encoded by CC chemokine receptor 7 （CCR7） is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus （EBV）, and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. To map the CCR7 gene in chicken chromosome, a 6000 rads chicken-hamster radiation hybrid panel （ChickRH6） was used. PCR of samples from ChickRH6 revealed that the location of CCR7 gene is linked to the maker SEQ0347 （6 cR away） with LOD score of 16.6 and that the marker SEQ0347 is located on chromosome 27 at 27 cR of RH （radiation hydrid） map. We compared the corresponding human mRNA sequence with the predicted coding sequence of chicken CCR7 gene, and found that the assembled contig shared a high percentage of similarity with that of the human gene.     

新形势下中小学校长绩效评价研究

中小学校长绩效效标是两个维度的,包括任务完成绩效与关系管理绩效;中小学校长绩效评价标准及相应的测验,既包括判断性测量指标,也包括非判断性测量指标.中小学校长绩效在性别、中小学区别、任职年限、城乡分布上均不存在显著性差异,但在一些维度上存在差异:在关系管理维度,小学校长的得分显著高于中学校长,乡村中小学校长的分数要显著性...     

胃癌ZAC基因的杂合性缺失检测

以30例胃癌组织和正常组织为研究对象,通过STR-PCR技术,对6号染色体6q24内的ZAC基因两侧的4个STR基因座进行杂合性缺失分析,统计这4个STR基因座在30例标本中的LOH频率,绘制它们的缺失图谱,得到了第4号和25号这两个样本中发生了包含ZAC基因在内的4285651bp的缺失,为进一步分析ZAC基因发生缺失的断裂点和查找ZAC基因表达下调的原因打下基础.     

萤火虫荧光素酶基困的反义RNA及其缺失片段阻抑基因表达的研究

利用离体转录载体ｐＳＰ１８、ｐＧＥＭ－３Ｚ和萤火虫荧光素酶基因（Ｌｕｃ）及其缺失片段构建了一组融合质粒。以这些质粒为模板，通过离体转录产生荧光素酶基因的ｍＲＮＡ，反义ＲＮＡ及大小和结构不同的反义ＲＮＡ缺失片段，再通过显微注射分别将其引入爪赡卵母细胞的细胞质。注射后的卵母细胞经一定时间培育，然后检测其翻译产物一荧光素酶的相对活性。结果表明，荧光素酶基因的表达受反义ＲＮＡ及其缺失片段的严重阻抑，表达抑制和反义ＲＮＡ之间存在明显的剂量效应。而且，基因表达的抑制程度主要的和反义ＲＮＡ片段的结构有关。     

Who benefits from homework assignments?

Using Dutch data on pupils in elementary school this paper is the first empirical study to analyze whether assigning homework has a heterogeneous impact on pupil achievement. Addressing potential biases by using a difference-in-difference approach, I find that the test score gap is larger in classes where everybody gets homework than in classes where nobody gets homework. More precisely pupils belonging to the upper part of the socioeconomic scale perform better when homework is given, whereas pupils from the lowest part are unaffected. At the same time more disadvantaged children get less help from their parents with their homework. Homework can therefore amplify existing inequalities through complementarities with home inputs.     

Public subsidies to private schools do make a difference for achievement in mathematics: Longitudinal evidence from Canada

Selection into private schools is the principal cause of bias when estimating the effect of private schooling on academic achievement. By exploiting the generous public subsidizing of private high schools in the province of Québec, the second most populous province in Canada, we identify the causal impact of attendance in a private high school on achievement in mathematics. Because the supply of highly subsidized spaces is much higher at the high school level than at the grade school level, 94% of transitions from the public to the private sector occur at the end of primary school, we assume that these transitions are exogenous with respect to changes in transitory unobserved variables affecting math scores conditional on variables such as changes in income and child fixed effects. Using 7 cycles of data from Statistics Canada's National Longitudinal Survey on Children and Youth (NLSCY), we estimate the effect of attending a private high school on the percentile rank and a standardized math test score with different models (child fixed effects, random effects and a pooled OLS) and restricted samples to control for the degree of selection. The results, interpreted as a treatment on the treated effect show that the effect of changing schools, from a public grade school to a private high school, increases the percentile rank of the math score between 4 and 10 points and by between 0.12 and 0.36 of a standard deviation depending on the specification and samples.     

基于进化生物学启示的企业知识创新探究

采用类比法,比照进化生物学的有关概念和理论从新的视角探究了企业知识创新有关问题。建立了基于知识的企业生物概念体系,较为深入地研究了企业专有知识(基因组)的创新机理,研究了企业专有知识的创新过程,其中重点构建和阐释了企业专有知识的持续创新系统图,并对企业专有知识持续创新的实施进行了探究。