基于Pro/E的压铸模设计及制造

基于Pro/E的CAD/CAM模块,以减速箱体为例介绍了压铸模的设计过程,利用Pro/E进行设计,大大缩短了产品研发周期、模具设计周期和加工周期,同时提高了产品设计的准确性,降低了产品开发和模具设计成本。     

管理心理学与图书馆管理工作

The article expounds how to use the basic theories and methods of manangement psychology to run the library so as to achieve good administrative result,improve work efficiency and push the work forward.     

中央信息管理与网络经济的宏观调控机制研究

在前期研究的基础上，本文探讨了构建中央信息库的必要性及其可能的构建方式与结构模型，设计了它对网络信息活动和网络经济运行的宏观调控机制。     

Attention‐Deficit/Hyperactivity Disorder Symptoms,Perceived Stress,and Resilience in College Students

This research investigated the relationships among symptoms associated with attention‐deficit/hyperactivity disorder (ADHD), perceived stress, and resilience in college students. In our study of 558 college students (175 men, 383 women), we confirmed the hypothesis that the relationship between ADHD symptoms and perceived stress is mediated by protective factors associated with resilience. The relationships were not significantly moderated by sex. Implications for increasing resilience in college students and lowering perceived stress for college students are discussed.     

高职学生在线学习投入量表构建与实证分析

学生的学习行为投入是影响学习效果的重要因素。为了了解疫情防控期间高职学生在线学习行为投入现状,在学习行为投入、在线学习行为投入内涵界定及测量研究的基础上设计了6个维度的高职学生在线学习行为投入测量量表,并基于学校电子商务学院2018级237名学生在安徽省网络课程学习中心(e会学)平台上进行在线学习的系统后台数据以及课后针对学习过程调查的问卷数据,对20个测量指标进行描述性分析、阶段性变化分析以及与终局性在线考试成绩进行相关分析。最后提出有效激发学生在线学习行为投入的实践启示,包括强化线上教学的过程管理;丰富线上教学设计,激发学生学习积极性;坚持线上教学的高要求。     

CHOP及GRP78在复发性多形性胶质母细胞瘤患者表达显著增加

目的:研究CHOP及GRP78与复发性GBM的相关性。方法:采用Western blot检测CHOP及GRP78在初发及复发GBM组织中的表达;Real-time PCR检测GRP78在初发以及复发GBM组织中的表达。结果:CHOP及GRP78在初发GBM中表达上调,而在经过原发性肿瘤切除后接受放疗和替莫唑胺化疗的复发性GBM中增加尤为显著。结论:CHOP及GRP78在GBM发病机制中起重要作用,该分子有望成为GMB潜在的诊断及预后评估标志物。     

基于系统动力学的在线学习投入度影响研究——学习生态观视角

为全面系统分析在线学习投入度影响因素,提升学习者在线学习质量,从学习生态观视角出发,使用系统动力学方法,构建学习者在线学习投入度影响因素系统动力学模型。采用层次分析法对模型进行仿真分析,结果显示：教学环境、社会交互环境、情感心理环境对学习者在线学习投入影响较强,物理环境和制度规范环境影响较弱。进一步分析表明,教学活动设计、与教师交互和情感体验是影响在线学习投入的高杠杆因素。从精心设计教学活动,优化教学环境;发挥教师主导作用,构造多边良性循环的社会交互环境;增强学习者情感体验,构建各子系统协同共建的情感心理环境等方面着手,致力于提升学习者在线学习质量,能促进在线学习系统平衡、协调和可持续发展。     

CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement

Since it was first recognized in bacteria and archaea as a mechanism for innate viral immunity in the early 2010 s,clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas) has rapidly been developed into a robust, multifunctional genome editing tool with many uses. Following the discovery of the initial CRISPR/Cas-based system, the technology has been advanced to facilitate a multitude of different functions. These include development as a base editor, prime editor, epigenetic editor, and CRISPR interference(CRISPRi) and CRISPR activator(CRISPRa) gene regulators. It can also be used for chromatin and RNA targeting and imaging. Its applications have proved revolutionary across numerous biological fields, especially in biomedical and agricultural improvement. As a diagnostic tool, CRISPR has been developed to aid the detection and screening of both human and plant diseases, and has even been applied during the current coronavirus disease 2019(COVID-19) pandemic. CRISPR/Cas is also being trialed as a new form of gene therapy for treating various human diseases, including cancers, and has aided drug development. In terms of agricultural breeding, precise targeting of biological pathways via CRISPR/Cas has been key to regulating molecular biosynthesis and allowing modification of proteins, starch, oil, and other functional components for crop improvement. Adding to this, CRISPR/Cas has been shown capable of significantly enhancing both plant tolerance to environmental stresses and overall crop yield via the targeting of various agronomically important gene regulators. Looking to the future, increasing the efficiency and precision of CRISPR/Cas delivery systems and limiting off-target activity are two major challenges for wider application of the technology. This review provides an in-depth overview of current CRISPR development, including the advantages and disadvantages of the technology,recent applications, and future considerations.     

"对分课堂"在高校课程教学中的应用与策略研究

"对分课堂"把教学划分为讲授、内化和讨论三个过程,核心理念是全责对分,以学生为中心,促进学生全面健康发展.在教学过程应用中,通过合理控制对分时间、对分模式、对分原则、对分流程,选择恰当教材、制定基于对分模式的教学设计、强调过程性考核等措施,达到教学效果最优化.     

网络环境下有效学习行为特征及影响因素研究

在网络环境下,学习者由于高度自由同时又缺乏有效的监管,学习很容易受到外界事件的干扰,并不能完全保证学习者的学习行为是有效的。为保证网络环境下学习的质量与绩效,有必要对网络环境下的有效学习行为进行深入研究。文章在“有效学习”定义基础上,提出网络环境下有效学习行为的概念及其特征,并详细讨论了网络环境下有效学习行为的主要影响因素,最后从中得到提高网络环境下学习行为有效性的启示:在课前,教师要做好学前分析,检查学习者是否已有本次学习必要的基础知识储备,并帮助学习者明确自己的学习目标,给学习者提供必要的学习环境;在课中,教师要注重学习者信息技术应用能力的培养,同时给学习者施加一定的外部动机,并结合具体情况,给予学习者有效的引导;在课后,教师需要及时对这节课进行反思总结。