Diagnostic and prognostic value of the urinary excretion of beta-aminoisobutyric acid in patients with urinary bladder cancer

Urinary excretion of beta-aminoisobutyric acid (BAIB), was determined in 28 active and 12 inactive bladder cancer patients. Mean excretion of BAIB was higher in active cancer patients-187.8 mg/24 hours whereas it was 120.4 mg/24 hours in inactive cancer patients. The increased BAIB excretion in both disease groups was independent of tumour stage. BAIB appears to be a useful diagnositic aid in the assessment of bladder cancer patients.     

Effect of antimalarials treatment on rat liver lysosomal function—Anin vivo study

Effects of treatmentin vivo with the antimalarials:chloroquine (CQ), primaquine (PQ) and quinine(Q) on lysosomal enzymes and lysosomal membrane integrity were examined. Treatment with the three antimalarials showed an apparent increase in the membrane stability. CQ treatment resulted in increase in both the ‘free’ and ‘total’ activities of all the enzymes i.e. acid phosphatase, RNase II, DNase II and cathepsin D. PQ treatment lowered the ‘free’ and ‘total’ activities of acid phosphatase and cathepsin D, but the DNase II activities increased. Treatment with Q resulted in increased ‘free’ and ‘total’ activities of RNase II and DNase II. While ‘free’ activities of acid phosphatase and cathepsin D were low; the ‘total’ activities increased significantly. Our results suggest that a generalized increase in free nucleases activities following prolonged treatment with antimalarials may lead to cell damage and/or necrosis.     

三子养亲汤及其味药脂肪酸成分的分析

我们在对三子养亲汤药效物质基础及其作用机理进行研究的过程中，以五种有代表性的脂肪酸（棕榈酸，硬脂酸，油酸，亚油酸，α－亚麻酸）为指标，用ＧＣ法对及其味药的脂肪酸成分进行了分析，同时也对其炮制品进行了对比测定．     

伞房花耳草中乌索酸的提取与鉴定(Ⅵ)

目的：提取分离及鉴定伞房花耳草活性成分乌索酸．方法：用“醇提凝析”法提取分离乌索酸,光谱鉴定其结构．结果：确证化合物为乌索酸,HPLC测定其含量为99．58％,得率3．12‰。结论：提取分离方法实用可行,乌索酸纯度高,安全性好。     

对甲苯磺酸催化合成氯乙酸异丙酯

本文报道了对甲苯磺酸在氯乙酸和异丙酸酯化作用中的应用，讨论中对甲苯磺酸催化合成氯乙酸异丙酯的条件，研究结果表明，其催化活性良好．     

3-氨基-4-羟基苯甲酸的合成

从3-硝基-4-氯苯甲酸,通过碱性水解、催化加氢及脱盐三步反应,合成得到3-氨基-4-羟基苯甲酸.结果表明,最佳NaOH水解量为5.0～5.5eq,时间为3.5h;正交试验催化加氢较佳条件为：H2压力为0.25Mpa,pH在5.4～5.6,反应温度为100℃,催化剂5%Pd-C的用量为2.5%（3-硝基-4-羟基苯甲酸）.氢化后粗品经重结晶得白色结晶体3-氨基-4-羟基苯甲酸盐酸盐,调pH至2,得3-氨基-4-羟基苯甲酸,纯度（HPLC）≥99.5%,反应总得率为84.3%.     

中国当前的主要环境问题

中国的环境污染日趋严重，其中全国性的，与国人关系最密切的主要问题是水体污染，土地危机和酸雨沉降，本文以数据说明这几个环境问题短期内就将影响到国人的生存，若不加大治理力度，我们将面临生存危机。     

二级微商法准确测定酸的含量

利用二级微商法对醋酸、草酸、柠檬酸等3种样品含量进行了测定,对此分析结果表明,该方法是一种理想的、快速简便的、准确度高的电位滴定方法.     

H_2O_2-抗坏血酸均相催化氧化法处理甲基橙

采用一种新的均相催化氧化体系——H2O2-抗坏血酸体系处理高浓度甲基橙模拟偶氮染料废水。通过改变过氧化氢、抗坏血酸投加量及溶液pH值、反应温度、时间等影响因素的实验与分析,研究了该体系对甲基橙脱色率的影响,并初步探讨了氧化降解的机理。结果表明,该体系能有效地使高浓度(1900mg/L)甲基橙溶液脱色,脱色率大于98%。     

微波辐射相转移催化合成对羟基苯甲酸杉酯的研究

以对羟基苯甲酸和氯化苄等为原料,以十六烷基溴化铵为相转移催化剂合成对羟基苯甲酸苄酯。通过实验考察了催化剂用量及物料配比等因素对酯化反应的影响。结果表明:微波辐射功率350W,辐射时间3min,n(对羟基苯甲酸)∶n(氯化苄)=1∶2,n(正十六烷基三甲基溴化铵)∶n(对羟基苯甲酸)=0.025,产率可达96.7%。