Combination of Se-methylselenocysteine,D-α-tocopheryl succinate, β-carotene,and L-lysine can prevent cancer metastases using as an adjuvant therapy

ObjectivePrimary tumor treatment through surgical resection and adjuvant therapy has been extensively studied, but there is a lack of effective strategies and drugs for the treatment of tumor metastases. Here, we describe a functional product based on a combination of compounds, which can be used as an adjuvant therapy and has well-known mechanisms for inhibiting cancer metastases, improving anti-cancer treatment, and enhancing immunity and antioxidant capacity. Our designed combination, named MVBL, consists of four inexpensive compounds: L-selenium-methylselenocysteine (MSC), D-‍α‍-tocopheryl succinic acid (VES), β‍-carotene (β‍-Ca), and L-lysine (Lys).MethodsThe effects of MVBL on cell viability, cell cycle, cell apoptosis, cell migration, cell invasion, reactive oxygen species (ROS), and paclitaxel (PTX)-combined treatment were studied in vitro. The inhibition of tumor metastasis, antioxidation, and immune enhancement capacity of MVBL were determined in vivo.ResultsMVBL exhibited higher toxicity to tumor cells than to normal cells. It did not significantly affect the cell cycle of cancer cells, but increased their apoptosis. Wound healing, adhesion, and transwell assays showed that MVBL significantly inhibited tumor cell migration, adhesion, and invasion. MVBL sensitized MDA-MB-231 breast cancer cells to PTX, indicating that it can be used as an adjuvant to enhance the therapeutic effect of chemotherapy drugs. In mice, experimental data showed that MVBL inhibited tumor metastasis, prolonged their survival time, and enhanced their antioxidant capacity and immune function.ConclusionsThis study revealed the roles of MVBL in improving immunity and antioxidation, preventing tumor growth, and inhibiting metastasis in vitro and in vivo. MVBL may be used as an adjuvant drug in cancer therapy for improving the survival and quality of life of cancer patients.     

两岸高职教育主要特色分析及其思考

对海峡两岸高职教育的教育体系、课程设置、产学结合三个主要方面的特色进行了比较分析,从另外的视角,有针对性地对高职教育的发展提出了看法。     

制约文化创意产业人才发展的问题分析

人才是文化创意产业发展的关键,优秀人才的匮乏成为目前制约产业发展的瓶颈.本文目的在于分析人才培养及使用过程中出现的问题,为创新人才培养模式提供参考.     

计算机编程在医学物理实验《转动惯量的测量》中的应用

通过对复杂的转动惯量计算过程进行程序化,并且利用条件判断实现对实验环节差错的识别,增强了学生对医学物理实验的兴趣,减轻了教师负担,提高了教学效率和效果,培养了学生解决实验问题的能力.     

新课改背景下的初中化学作业设计

以“激发兴趣，尊重和促进个性发展，培养合作精神，激发创新潜能，提高实践能力”为宗旨，初中化学作业设计应体现人文性、实用性、探究性、合作性，从而提高学生各方面的素质，达到新课程标准的要求．     

数学中的发现与突破

作者着重从几个角度来探讨数学中发现的契机、思想与技巧,同时探讨了发现问题以后如何带着目的进行完善性的理论构建.     

采用有效的控制,提高实验教学质量

控制理论是管理学重要原理之一,在实验教学中应用控制理论,采用有效的控制方法和手段,能够更好地提高实验教学的管理水平和教学质量。     

微分方程解的唯一性定理的再证明

在文[1]的基础上运用序列的一致收敛性及两个区间相合的概念再给出微分方程解的唯一性定理的三种证法．     

论教师的实践智慧

教学活动的复杂多变需要教师拥有实践智慧,而教师的实践智慧因其具有动态生成、不可言说、独一无二等主要特征,与教学经验、教学理论有着密切关系,但又完全不同。在教学中,它通常外显为对知识传授的超越、教学机智以及教师对自我完善的不懈追求。     

多样性与未来文化的可持续发展

当文化的同一性减少我们的快乐和我们智力的、情感的、物质的财富时,多样性是有益的。文化多样性可以为所有人提供扩大文化选择权的机会。如果文化的多样性及其自由能够得到保证,那么文化也就获得了可持续发展的前提、动力和资源。