高通量药物筛选中靶分子固定化数学物理模型的建立

通过对高能量药物筛选基本过程的分析 ,探索了靶分子固定化可能对筛选质量构成的影响 .从分子相互作用看 ,实际的过程远较理想的情况复杂 .分子间存在的静电力、疏水作用力及氢键力能对固定化的机理构成较大影响 ,甚至可能诱发多层吸附的固定化模式 .基于固定化过程中可能存在的靶分子与靶分子、靶分子与微球、体相与表面相之间的相互作用 ,构筑了相应的数学物理模型 ,为实际的筛选工作提供了可参考的理论依据 .     

Overview of Preventive Conservation Research Work on Seismic Mitigation and Subway Vibration Control in Chengdu Museum of China

ABSTRACT

The 2008 Wenchuan earthquake brought numerous issues to the attention of researchers of seismic mitigation in Chinese museums. After the Wenchuan earthquake, the structural design team of Chengdu Museum conducted a series of research projects on seismic mitigation and subway vibration control design of buildings. These projects included the following topics: optimization of design, numerical simulation of seismic performance, analysis of key technologies for the base isolation structure, in-depth studies on structural vibrations caused by the nearby subway, and proposals for reducing structural vibrations. In 2015, after the superstructure of Chengdu Museum was completed, conservators evaluated the safety of permanent exhibitions under earthquake conditions. Seismic protection devices were installed on the showcases according to the preventive conservation requirements for museum collections. Reinforced measures were used for museum collections according to the methods suggested in the document ‘Specification for seismic protection of museum collection’ (WW/T 0069-2015). The conservators also built a systematic platform for earthquake monitoring for museum collections. Preventive conservation studies on seismic protection and subway vibration control in Chengdu Museum are summarized and forecasted.     

老子"道"的社会意义

老子思想的核心概念是"道",而道最根本的性质是"自然"、"无为而无不为".落实到社会问题上,最好的治国之道是"功成事遂,百姓皆谓我自然." "无以为"与"无不为"应该是老子无为思想的两个方面,缺一不可,互相补充.在此基础上,老子对儒家的仁、义、礼等作了评论和批判.在当时人们特别是统治者太"有为"的情况下,老子的这一思想有着解毒剂的作用,但它也容易招致误解,而且这一思想本身也并非无可挑剔.     

国家级预防医学实验教学示范中心的建设与展望

为满足当今社会对卫生防病人才的更高要求,更新传统的实验教学观念,构建全新的实验教学体系。教学内容以三基训练为基础,以培养学生的能力为重点,经过10年的建设与探索,总结出成功的经验。为适应我国公共卫生事业的发展,按照预防医学实验教学新体系和构筑宽口径实验教学平台的整体构思,在全国率先组建涵盖多学科的预防医学实验教学示范中心,对各学科开设的实验教学内容打破学科界限,有机整合,统筹安排,提高了学生的实验操作、设计和创新能力,中心建设的总体思路、运行机制得到了国内外40多所高校专家的认可。建立了涵盖多学科的实验教学示范中心;构建了新的实验教学体系;改革预防医学实验教学内容、方法、方式等,提高了学生的整体素质。中心十二五将在智能化、网络化的实验教学和实验室管理信息方面有突破。     

Action groups as a participative strategy for leading whole-school health promotion: Results on implementation from the INCLUSIVE trial in English secondary schools

Education policy increasingly promotes action groups as a key strategy for student and/or staff participation in school improvement and whole-school health promotion. Such groups can coordinate multi-component interventions, increase participation and engagement, and enable local adaptations, but few process evaluations have assessed this. We evaluated fidelity, feasibility and acceptability of action groups as part of a trial of a whole-school intervention to reduce bullying and aggression and promote health in English secondary schools, which reported multiple health and educational impacts. Action groups involved students and staff, supported by external facilitators, and drew on data on student needs. They aimed to: coordinate implementation of restorative practices and a social and emotional competencies curriculum; review policies and rules; and enact local decisions to modify school environments. Our process evaluation used interviews, focus groups, observations and questionnaires to assess action groups’ fidelity, role in coordination, role in local adaptation, support from external facilitators and data on student needs, and acceptability in engaging members. Fidelity was high in the first two years but lower in the third year when external facilitators withdrew. Student needs data were perceived as useful, but views on external facilitators were mixed. Groups successfully reviewed policies and rules, planned activities and coordinated restorative practices, but were less successful in implementing the curriculum. Success was facilitated by the involvement of school leaders. Members reported high satisfaction and empowerment. Action groups are a promising strategy for leading whole-school health promotion. Implementation is supported by external facilitation, local data and involvement of senior managers.     

高校设备采购工作廉政风险探讨

从业务流程、制度机制、外部环境等方面认真分析了高校设备采购过程中存在或潜在的风险点,结合工作实际对风险点的防治措施进行了详细探讨,并阐述了笔者工作中的具体做法。     

基于行为链模式对汉英动宾结构构建的研究

通过行为链模式对比分析汉、英动宾结构的构建过程,发现汉、英动宾结构存在普遍相似性,除典型动宾结构呈现对称性特征外,英语动宾结构在构建过程中也体现了语义结构的兼容能力,出现代体宾语的现象,进一步证实了思维的隐喻性与转喻性是人类所共有的普遍认知方式;另一方面,汉、英动宾结构的构建过程也存在明显差异性,行为链模式相逆相异,表现为英语缺少施事宾语,而汉语少见同源宾语等,另外,英语的代体宾语数量远远低于I汉语,说明各民族虽然具有相仿的认知方式,但认知过程均有所不同。     

唤起理性思考引发行动变化

教研活动是教师职后培训的重要形式,是教师个人发展的重要途径。研训教师应该走出去,学习新理论,接收新观念,开拓新思维,以理性思考来引发行动变化。     

刘应秋《一砚斋集》用典论略（下）

在《一砚斋集》中,刘应秋能够灵活使用不同典故来表达丰富多彩的情感内容,或抒情言志,或送别赠友,或写景记事,或唱和宴饮,同时通过一典多用、类典叠用、活用化用等不同手法的运用,取得了很好的修辞效果,也显示了刘应秋扎实的文学功底和高超的艺术表现力。     

浅谈影响水工混凝土质量的几种病害和预防措施

水工混凝土的质量直接影响工程的使用寿命、加固费用、效益发挥和运行安全。分析水工混凝土的几种病害,并从工程设计、工程原材料、施工工艺、运行管理等方面提出预防措施,以提高水工混凝土建筑物的耐久性。