False negativity to carbohydrate-deficient transferrin and drugs: a clinical case

Introduction:

In this work we report on the possible effect of the medical therapy on CDT concentration in a chronic alcohol abuser, with known medical history (July 2007 – April 2012) and alcohol abuse confirmed by relatives.

Case history:

At the end of 2007, patient displayed the following laboratory results: AST 137 U/L, ALT 120 U/L, GGT 434 U/L, MCV 101 fL and CDT 3.3%. On December 2007, after double coronary artery bypass surgery, he began a pharmacological treatment with amlodipine, perindopril, atorvastatin, isosorbide mononitrate, carvedilol, ticlopidine and pantoprazole. In the next months, until may 2011, the patient resumed alcohol abuse, as confirmed by relatives; however, CDT values were repeatedly found negative (0.8% and 1.1%) despite elevated transaminases and GGT, concurrent elevated ethyl glucuronide concentration (> 50 mg/L) and blood alcohol concentration (> 1 g/L). Alcohol consumption still continued despite increasing disulfiram doses ordered by an Alcohol Rehab Center. On May 2011, the patient was transferred to a private medical center where he currently lives.

Conclusions:

This study suggests the possibility that a medical therapy including different drugs may hamper the identification of chronic alcohol abusers by CDT.     

Comparison of digoxin concentration in plastic serum tubes with clot activator and heparinized plasma tubes

Introduction:

Sample type recommended by the manufacturer for the digoxin Abbott assay is either serum collected in glass tubes or plasma (sodium heparin, lithium heparin, citrate, EDTA or oxalate as anticoagulant) collected in plastic tubes. In our hospital samples are collected in plastic tubes. Our hypothesis was that the serum sample collected in plastic serum tube can be used interchangeably with plasma sample for measurement of digoxin concentration. Our aim was verification of plastic serum tubes for determination of digoxin concentration.

Materials and methods:

Concentration of digoxin was determined simultaneously in 26 venous blood plasma (plastic Vacuette, LH Lithium heparin) and serum (plastic Vacuette, Z Serum Clot activator; both Greiner Bio-One GmbH, Kremsmünster, Austria) samples, on Abbott AxSYM analyzer using the original Abbott Digoxin III assay (Abbott, Wiesbaden, Germany). Tube comparability was assessed using the Passing Bablok regression and Bland-Altman plot.

Results:

Serum and plasma digoxin concentrations are comparable. Passing Bablok intercept (0.08 [95% CI = −0.10 to 0.20]) and slope (0.99 [95% CI = 0.92 to 1.11]) showed there is no constant or proportional error.

Conclusion:

Blood samples drawn in plastic serum tubes and plastic plasma tubes can be interchangeably used for determination of digoxin concentration.     

意象对话技术治疗强制隔离戒毒人员抑郁症个案报告

本文是用意象对话技术对一名企图自杀的抑郁症强制隔离戒毒人员进行心理治疗的个案研究。通过积极干预、意象呈现、修改意象、改变或重构意象等技术,鼓励来访者勇敢地面对问题,消除不合理的期望,最终实现生活态度的转变和自我人格的积极成长。     

高等体育院校校医院药品管理的实践探讨

根据药品管理的理论及法规,结合北京体育大学校医院的特点,探讨了高等体育院校校医院药品管理的特点,认为:药品具有特殊用途,并且是治疗的重要工具之一,药品管理应该把握好购药原则与规划,利用各种手段完善药库管理,把握好不同药品的管理,更好的满足教职员工和学生的医疗需要.     

芒市地区女性生殖道支原体感染状况及药敏分析

目的：了解芒市地区女性生殖道支原体感染情况及耐药情况。方法：采集932例女性宫颈分泌物标本分别做支原体培养及药物敏感性分析。结果：从932例标本中,检出支原体636例,阳性率为68.2%（636/932）,其中解脲脲原体单项感染447例,阳性率48.0%（447/932）,人型支原体单项感染8例,阳性率0.9%（8/932）,解脲脲原体和人型支原体混合感染182例,阳性率19.5%（182/932）。结论：当地女性生殖道支原体的感染率较高,且以解脲脲原体为主,环丙沙星和红霉素耐药率较高,推荐使用交沙霉素和美满霉素。     

县级食药品安全监管体制改革的实践探索个案分析

郧县食药监管改革从2013年下半年开始,到2014年4月基本到位,改革的过程中,紧密结合实际,不断创新思路,探索了一些有效办法,使改革按照国务院的指导意见,较好地完成了改革任务,实现了平稳有序顺利的目标,成为鄂西北山区十堰市所有县市区最先改革到位的县。但是,后续仍有许多问题需要研究解决,要经过＂学中干、干中学＂的探索过程,不断总结完善,良性发展。     

286株鲍曼不动杆菌临床分布及耐药性分析

目的 监测鲍曼不动杆菌临床分布特点及耐药性,为临床鲍曼不动杆菌导致的感染性疾病诊断与合理用药提供理论依据.方法 对2012年1至12月襄阳市第一人民医院门诊及住院部送检标本进行常规细菌分离培养和鉴定,并按照NCCLS标准用K-B法对分离的病原菌进行药物敏感试验,统计分析鲍曼不动杆菌临床分布及耐药性.结果 鲍曼不动杆菌在送检标本中主要来源于痰液（80.07％）,其次是尿液（8.04％）、脓汁（5.24％）等;其耐药性严重,耐药率最低的抗菌药物是亚胺培南,也高达49.30％,对阿米卡星、哌拉西林等其余14种抗菌药物耐药性均大于60.00％.结论 鲍曼不动杆菌分离以痰液标本为主,临床上主要引起呼吸道感染;其耐药性严重,应根据药敏试验结果合理选择抗菌药物.     

吸毒与非吸毒人员的自我监控研究

吸毒串联模式认为,吸毒起源于社会适应不良特质。为进一步探讨社会行为自我监控跟适应不良有关,该研究对686名吸毒人员和269名非吸毒人员施测了单维度自我监控量表和三维度自我监控量表。结果发现,吸毒人员与非吸毒人员在单维度自我监控量表上得分没有显著差异,但在三维度自我监控量表上存在显著差异。在他人导向和自我导向子量表上,吸毒人员得分要显著高于非吸毒人员,但在高自我监控量表上得分要明显低于非吸毒人员。该结果说明吸毒跟社会行为自我监控有关;同时证明个体与社会关系建构成三个维度,比区分为一个维度的两极更有效。     

浅谈纳米给药的现状,进展,问题和前景

通过文献中描述的药动学、毒理学研究结果得知纳米给药系统的特点及纳米给药系统在医药领域的应用中的优势,主要是在肿瘤治疗领域的作用,最后概括纳米给药系统的前景及展望。     

清热解毒法治疗玫瑰糠疹的临床观察

目的：探讨自拟中药清热解毒法治疗50例玫瑰糠疹的临床疗效。方法：将100例玫瑰糠疹患者随机分为中药治疗组50例和西药对照组50例。治疗组采用中药方剂清热解毒汤温热口服;对照组以西药治疗,用开瑞坦片10 mg/次,1次/d,口服;维生素C片100 mg/次,3次/d,口服。结果：治疗组有效率为94%,对照组为70%,二者差异有显著性（P〈0.05）。结论：清热解毒法治疗玫瑰糠疹有显著疗效。