猪链球菌分离株的分群鉴定及药敏试验

2001至2003年,从安阳、邯郸等6个地区采取180份猪的病料,从中分离到50株链球菌,对其中20株典型分离株进行了生化分群鉴定、兰氏分群A—G诊断试剂鉴定和药敏试验。结果表明,6个地区发生的猪链球菌病主要由C群(6/20),D群(4/20),E群(5/20)和G群(2/20)链球菌引起,其分布无明显地域性。药敏试验结果表明,对环丙沙星、强力霉素等高度敏感,敏感菌株达95%以上,可作为防治猪链球菌病的首选药物。     

Drug prevention for young people with social,emotional and behavioural difficulties attending special education provision

The levels of drug use amongst school‐aged young people have risen over the past decade. Prevention initiatives have been developed using empirical evidence obtained from school‐based surveys. The empirical evidence base of drug use amongst young people with social, emotional and behavioural difficulties (SEBD) attending special education provision is very limited. The implications of this knowledge gap for addressing drug use amongst these young people are explored in this paper. Proposals for the way forward are suggested, for developing a framework for targeted evidence‐based interventions for young people attending emotional and behavioural difficulty units.     

黄冈职院附属医院抗菌药物应用情况分析

目的了解黄冈职院附属医院抗菌药物的使用情况,为规范医院使用抗菌药物提供依据。方法收集附属医院近三年来抗菌药物的用药品种、销售金额、使用频率,日均消费进行统计和分析。结果抗菌药物用药品种、金额、频率、日均消费、剂型较为规范,但国家基本药物抗菌药物品种的应用在逐年下降。结论附属医院对抗菌药物的临床应用基本合理,但是对国家基本药物应用的逐年下降趋势,应引起重视,及时调整。     

论齐梁药名诗

齐梁药名诗的出现标志着药名诗在诗歌史上的确立,它体现了诗歌发展过程中的一个必然阶段,推动了诗歌的成熟;反映了齐梁诗人的活动状况,展示了士人的学识素养;传播了学科知识,拓展了诗歌的功用。它用自身的形态和价值丰富了诗歌的百花园,是中华民族宝贵的文化遗产。     

数据挖掘技术在连锁药店管理中的应用研究

以亳州盖福祥连锁药店为例,利用关联规则对数据库中药品的销售信息进行挖掘及利用NK—means聚类算法对顾客忠诚度进行聚类分析研究,找出影响连锁药店盈利的主要因素,为连锁药店改进营销策略、提高服务质量提供参考依据。     

民族地区药管专业实训教学面临的困境与对策--以广西民族师范学院为例

实训教学是技能培养的重要组成部分,在人才培养过程中越来越发挥出它的重要作用。民族地区药管专业在实训过程中遇到了实训机会较少,市场容量有限、管理不到位,学生难以“走出去”,实训岗位单一化,实训效果难以考核等各种困境,因此,必须采取行之有效的对策,应用创新的眼光去摸索一种符合实际的实训教学模式,以提高药管专业的实训教学效果。     

Exploring adverse drug reactions of diabetes medicine using social media analytics and interactive visualizations

The aim of this study is to propose an automatic and real-time social media analytics framework with interactive data visualizations to support effective exploration of knowledge about adverse drug reaction (ADR) surveillance. This proposed framework has been prototypically implemented on the basis of social media data. A longitudinal diabetes patient online community data (AskaPatient.com) as well as FDA Adverse Event Reporting Systems (FAERS) data as a benchmark were used to evaluate our proposed approach’s performance. Based on the results, our approach significantly increases the precision and accuracy for ADR extraction. The number of ADR cases, the time when the ADRs occurred, and the rating of Glucophage have been visualized that resulted by mining a collection of 870 ADRs posted in Askapatents.com over a certain time period (from 2001 to 2015). The results have important implications for pharmaceutical companies and hospitals wishing to monitor ADRs of medicines.     

School exclusion,substance misuse and use of weapons: an interpretative phenomenological analysis of interviews with children

The study presents data drawn from semi-structured interviews with five young people permanently excluded from schools in North East England. The research aimed to investigate the risk factors that lead to the children using illegal drugs, to determine the drivers and implications for drug misuse and the carrying of knives into school. The research also hoped to elicit from the young people, the solutions that could have prevented their exclusion from school. The interviews were analysed using interpretative phenomenological analysis to understand how a homogenous sample made sense of their lived experiences. The findings highlight the importance of prompt identification and support for children with learning and subsequent mental health needs as the evidence suggests they lead to perceived negative behaviours by teachers. The research provides further evidence that behaviour sanctions in mainstream schools such as detention and isolation booths do not improve behaviour but make it worse. Original to this research is the finding that children are consuming drugs before school to cope with their inability to access the learning, to aid their concentration and to medicate themselves to reduce the likelihood of being sanctioned by teachers.     

利用STN解决药物研发过程中的信息需求

药物研发是一个漫长、复杂、且花费昂贵的科研活动过程,其文献信息支持工作非常关键,并贯穿于药物研发的全过程。利用STN国际联机数据库,可解决药物研发过程中的信息需求。     

白藜芦醇/富勒烯纳米组装体的制备——在胆管支架抗炎涂层中的应用评估

采用白藜芦醇(Res)和富勒烯(C60)结合制备Res/C60纳米组装体并验证其安全性和抗炎性。通过扫描电子显微镜(SEM)、拉曼光谱和X射线衍射研究了纳米组装体形貌、粒径大小及波谱峰值特征。其次,通过紫外分光光度法研究了Res的药物缓释行为。最后,通过MTT法在人脐静脉内皮细胞(HUVECs)层面验证了Res/C60纳米组装体的安全性以及体外的抗炎性。研究发现,Res/C60纳米组装体呈短棒状,横截面平均直径为(379.74±33.47)nm。拉曼光谱和X射线衍射特征峰显示Res/C60纳米组装体被成功制备。Res/C60纳米组装体的聚氨酯(PU)涂层中Res药物在30 d内累积释放量可达60%左右。胆管支架涂层对HUVECs细胞毒性较低,且通过释放Res可显著抑制炎症因子的释放。