大学创业生态系统的架构与构建路径

大学创业生态系统是促进学术创业和创业教育实现良性可持续发展的基石,但构建大学创业生态系统仍缺乏理论指导。兼顾组织和制度层面,采用一个双元分析框架,对芬兰阿尔托大学和瑞典隆德大学两所大学案例进行深入分析,在理论上提出大学创业生态系统的架构与构建路径,深化大学创业生态系统的研究。     

论债权人兼股东的主银行

文章从债权人兼股东的角度对日本的主银行制进行了理论研究。第一 ,分析了债权人兼股东、债权人、股东这三个主体的利害关系 ,阐明了债权人兼股东的利益中立性是主银行制存在的前提。第二 ,分析了信息非对称时主银行的信号传递机制及其协作机制 ,并导出了债权人兼股东的性质是主银行发挥其作用的必要保证等结论。日本持股主银行制对中国有参考价值     

卡思卡特城堡

It is worthy of noting that, whilst Crookston Castle witnessed the earlier and happier portion of Mary's variegated life,     

在日语教学中对文化导入的研究与实践

语言教学是文化传播的重要途径。任何语言都是某种文化的特定反映,是文化传播的载体,不能离开文化独立存在。因此在日语教学中对跨文化知识要有足够的重视。在语法、词汇等语言基础知识讲授中适度的文化导入能帮助学生更准确地掌握所学的语言知识,提高学生实际运用语言的能力,使课堂教学更加直观生动,提高教学效率。     

实践取向的西部农村职业教育发展策略探讨

近年来西部经济社会发展迅速,但是,农村职业教育中问题较多,特别是西部农村职业教育专业结构不合理、学生实践技能培养不到位、教育导向背离农村发展实际等,严重制约着西部农村经济的持续快速发展。为此,必须通过围绕西部农村建设需要尽快调整农村职业教育专业结构、开发项目课程,突出实践导向、加强工学结合,强化职业技能和政府提供农村职业教育经费等措施,实现西部农村职业教育与区域经济的协调持续快速发展。     

供应链政策与企业技术创新 ——来自政府认定供应链创新试点企业的经验证据

利用2018年9月商务部等8部门联合启动的“全国供应链创新与应用试点”为准自然实验场景,采用双重差分倾向得分匹配法（PSM-DID）探究供应链政策对企业技术创新的影响。研究发现：供应链创新试点项目实施后的第二年,试点企业的技术创新水平显著提升;进一步研究发现对于非国有企业、成熟期企业、冗余资源较多以及供应链集中度高的企业,这种提升作用更为显著。此外,采用事件研究法和Heckman两阶段模型,从资本市场反应的视角证实了供应链创新试点影响企业技术创新过程中的信号传递机制,且这种信号的有效性受企业生命周期和供应链集中度影响。     

Improvement of a gene targeting system for genetic manipulation in Penicillium digitatumQian XU,Cong-yi ZHU,Ming-shang WANG,Xue-peng SUN,Hong-ye LI简

Penicillium digitatum is the most important pathogen of postharvest citrus. Gene targeting can be done in P. digitatum using homologous recombination via Agrobacterium tumefaciens mediated transformation (ATMT), but the frequencies are often very low. In the present study, we replaced the Ku80 homolog (a gene of the non-homologous end-joining (NHEJ) pathway) with the hygromycin resistance cassette (hph) by ATMT. No significant change in vegetative growth, conidiation, or pathogenicity was observed in Ku80-deficient strain (ΔPdKu80) of P. digitatum. However, using ΔPdKu80 as a targeting strain, the gene-targeting frequencies for both genes PdbrlA and PdmpkA were significantly increased. These results suggest that Ku80 plays an important role in homologous integration and the created ΔPdKu80 strain would be a good candidate for rapid gene function analysis in P. digitatum.     

前列腺癌:亟待肿瘤标志物和治疗新靶点(英文)简

Prostate cancer （PCa） incidence and mortality have decreased in recent years. Nonetheless, it remains one of the most prevalent cancers in men, being a disquieting cause of men＇s death worldwide. Changes in many cell signaling pathways have a predominant role in the onset, development, and progression of the disease. These include prominent pathways involved in the growth, apoptosis, and angiogenesis of the normal prostate gland, such as an- drogen and estrogen signaling, and other growth factor signaling pathways. Understanding the foundations of PCa is leading to the discovery of key molecules that could be used to improve patient management. The ideal scenario would be to have a panel of molecules, preferably detectable in body fluids, that are specific and sensitive biomarkers for PCa In the early stages, androgen deprivation is the gold standard therapy. However, as the cancer progresses, it even- tually becomes independent of androgens, and hormonal therapy fails. For this reason, androgen-independent PCa is still a major therapeutic challenge. By disrupting specific protein interactions or manipulating the expression of some key molecules, it might be possible to regulate tumor growth and metastasis formation, avoiding the systemic side effects of current therapies. Clinical trials are already underway to assess the efficacy of molecules specially designed to target key proteins or protein interactions. In this review, we address that recent progress made towards under- standing PCa development and the molecular pathways underlying this pathology. We also discuss relevant molecular markers for the management of PCa and new therapeutic challenges.     

澜湄合作机制下中柬水资源合作路径

目前,中柬水资源合作以技术援助、试点示范、水文信息共享和产能合作为主,但总体上合作水平层次还不高,合作范围还有较大的扩展空间.在构建中柬命运共同体的双边合作历史机遇和新型的澜湄多边合作框架下,未来如何深入推进中柬水资源合作?本文通过构建跨境河流合作动因—阶段分析框架,在系统梳理柬埔寨水资源开发利用、水旱灾害防治、水...