PI-3 kinase pathway can mediate the effect of TGF-β1 in inducing the expression of SHARP-2 in LLC-PK1 cells

1-3 kinase pathway can mediate this effect.     

The influence of parents on undergraduate and graduate students’ entering the STEM disciplines and STEM careers

This research examines the influence of parents on students’ studying the STEM disciplines and entering STEM careers. Cases of two graduate students (one female, one male) and one undergraduate student (male) are featured. The first two students in the convenience sample are biology and physics majors in a STEM teacher education programme; the third is enrolled in computer science. The narrative inquiry research method is used to elucidate the students’ academic trajectories. Incidents of circumstantial and planned parent curriculum making surfaced when the data was serially interpreted. Other themes included: (1) relationships between (student) learners and (teacher) parents, (2) invitations to inquiry, (3) modes of inquiry, (4) the improbability of certainty, and (5) changed narratives?=?changed lives. While policy briefs provide sweeping statements about parents’ positive effects on their children, narrative inquiries such as this one illuminate parents’ inquiry moves within home environments. These actions became retrospectively revealed in their adult children’s lived narratives. Nurtured by their mothers and/or fathers, students enter STEM disciplines and STEM-related careers through multiple pathways in addition to the anticipated pipeline.     

Source preferences in the context of seeking problem-specific information

The study focuses on the ways in which people define their source preferences in the context of seeking problem-specific information for non-work purposes. The conceptual framework draws on two major concepts, that is, information source horizon and information pathways. The former denotes the ways information sources are mapped in preference order in an imaginary field, while information pathways refers to the sequences in which sources placed on the information source horizon are actually used. The empirical part of the study draws on semi-structured interviews with 18 individuals active in environmental issues. Human sources and the Internet were preferred most strongly in seeking for problem-based information. The major source preferences were content of information, and availability and accessibility. Usability of information sources and user characteristics were mentioned less frequently as preference criteria. Typically, information pathways consisted of the use of 3–4 sources. On average, human and networked sources were favored in the early phases of information seeking. Printed media such as magazines and organizational sources were often used to complement information received from human sources and the Internet. However, the source preferences varied considerably, depending on the requirements of the problem at hand.     

盈余质量对控股股东掏空的影响

传统的研究认为,会计信息的质量高低是公司治理的结果,然而本文发现,会计信息质量还可以预示公司治理的效果.具体而言,本文以应计质量为盈余质量的度量,考察了在不同控制权水平下,盈余质量对掏空行为的预示作用.研究发现,当期的盈余质量能够有效预示当年、1年后和2年后的掏空行为,而控股股东的控制权水平对盈余质量的预示作用有显著影响.     

阿维菌素生物合成及其代谢途径研究进展

阿维菌素(avermectin)是由阿维链霉菌(Streptomyces avermitilis)产生的一种具有杀虫活性的大环内酯类抗生素,在农业和畜牧业中应用广泛。本文综述了有关阿维菌素生物合成以及阿维菌素育种和代谢工程方面的最新研究进展。     

Effects of nanofibers on mesenchymal stem cells: environmental factors affecting cell adhesion and osteogenic differentiation and their mechanisms

Journal of Zhejiang University-SCIENCE B - Nanofibers can mimic natural tissue structure by creating a more suitable environment for cells to grow, prompting a wide application of nanofiber...     

从经济安全看我国的自主创新能力

冷战结束后，经济因素在国际关系中地位上升，以经济、科技为核心的综合国力竞争成为国际竞争的焦点，经济、科技发展战略便成为维护国家安全的核心内容。经济安全最终取决于自主创新能力的提高，为保障国家经济安全，我国必须走创新型国家发展道路，不断增强核心技术领域的自主创新能力。     

制度变迁的基本属性与转型路径比较

制度变迁是一个涉及制度系统内复杂的多要素及其相互“博弈”的过程 ,初始条件和路径依赖导致“制度均衡”的多样性和互补性。转型经济制度变迁过程的比较分析表明 ,制度变迁与路径选择并无固定的模式 ,但经济持续增长、社会福利最大化、资源配置符合帕累托改进性质等 ,应是包括中国在内的任何一个转型国家在制度变迁过程中追求的多重目标。     

细胞质lncRNAs与肿瘤信号调控（英文）

恶性肿瘤疾病长期作为危害人类健康的重要隐患,目前针对重要信号调控通路的一系列靶向抑制剂在临床后期业已出现耐药现象,迫切要求人们在肿瘤生物学研究和靶向治疗方向不断寻找新的可替代性靶点。长链非编码RNAs(lnc RNAs)作为最新关注的研究热点,其在肿瘤发生和转移中的重要调节功能不断被我们及相关学者重点报道。随着RNA通量深度测序等相关研究技术的推广和发展,使人们得以饱览赏析lnc RNAs作为健康和疾病重要调节因子的宏观图谱。本综述总结了胞质lnc RNAs在调节肿瘤重要信号通路中的研究进展及其在肿瘤发生发展中的作用,为癌症的预前预后和靶向治疗提供帮助。     

Internet下一代QoS信令研究

该文介绍了IETF下一代信令工作组NSIS（Next Step In Signaling）的QoS信令协议框架,分析了区分服务网络QoS信令模型-RMD（Resource Management in DiffServ）及其聚集预留状态管理算法。仿真实验证明,在负载较重的情况下,受网络时延抖动和信令分组丢失的影响,RMD难以保证聚集流的服务质量,并指出需要采用适当的分组调度策略以解决该问题。