不同抗阻训练方案对T淋巴细胞亚群迁移和凋亡的影响*

研究旨在探讨一次不同抗阻训练方案对外周血CD4＋和CD8＋T淋巴细胞亚群迁移和凋亡的影响。通过实验法15名无训练经历的健康青年男性分别进行一次以促进肌肉肥大（H-RT组,方案：70%1RM,10RM,3组,组间间歇1.5 min）和以改善肌肉耐力（E-RT组,方案：60%1RM,15RM,3组,组间间歇1 min）为目的的抗阻训练方案。并于训练前、训练后即刻、训练后2 h和24 h利用流式细胞仪测定表面标志物CX3CR1和annexin V表达量检测CD4＋、CD8＋T淋巴细胞亚群迁移和凋亡（用阳性表达率表示）。得出以下数据：（1）CD4＋T细胞在H-RT组运动后即刻和运动后24 h,annexin V和CX3CR1阳性表达率显著性升高（P<0.05）。E-RT组annexin V阳性表达率在运动后即刻降低（P<0.05）,24 h显著性升高（P<0.05）;CX3CR1阳性表达率仅在运动后即刻升高（P<0.05）。（2）CD8＋T细胞在H-RT组和E-RT组运动后即刻和运动后24 h,annexin V和CX3CR1阳性表达率均显著性升高（P<0.05）。通过对以上数据的分析,研究得出以下结论：CD4＋T淋巴细胞亚群对于急性抗阻训练的免疫反应存在运动方案依赖性。     

Blood flow restriction in human skeletal muscle during rest periods after high-load resistance training down-regulates miR-206 and induces Pax7

BackgroudBlood flow restriction (BFR) with low-intensity resistance training has been shown to result in hypertrophy of skeletal muscle. In this study, we tested the hypothesis that BFR during the rest periods between acute, high-intensity resistance exercise sessions (70% of 1 repetition maximum, 7 sets with 10 repetitions) enhances the effects of the resistance training.MethodsA total of 7 healthy young men performed squats, and between sets BFR was carried out on one leg while the other leg served as a control. Because BFR was applied during rest periods, even severe occlusion pressure (approximately 230 mmHg), which almost completely blocked blood flow, was well-tolerated by the participants. Five muscle-specific microRNAs were measured from the biopsy samples, which were taken 2 h after the acute training.ResultsDoppler data showed that the pattern of blood flow recovery changed significantly between the first and last BFR. microRNA-206 levels significantly decreased in the BFR leg compared to the control. The mRNA levels of RAC-β serine/threonine-protein kinase v22, nuclear respiratory factor 1, vascular endothelial growth factor, lupus Ku autoantigen protein p70 genes (p < 0.05), and paired box 7 (p < 0.01) increased in the BFR leg. The protein levels of paired box 7, nuclear respiratory factor 1, and peroxisome proliferator-activated receptor γ coactivator 1α did not differ between the BFR leg and the control leg.ConclusionBFR, during the rest periods of high-load resistance training, could lead to mRNA elevation of those proteins that regulate angiogenesis, mitochondrial biogenesis, and muscle hypertrophy and repair. However, BFR also can cause DNA damage, judging from the increase in mRNA levels of lupus Ku autoantigen protein p70.     

略论李烈钧的抗日主张

“九·一八”事变后,由于南京国民政府奉行不抵抗政策,日本侵略者气焰更加嚣张。这时李烈钧便提出“开放政权”、“实行民治”、“内部一致”、共同抗日,以及挽救民族危亡的主张,并向政府与蒋介石对日侵略所采取的态度和政策提出了批评。     

珙桐生理学研究进展

珙桐(Davidia involucrate Baill)是中国特有的单属单种植物,国家一级保护物种,具有重要的学术、经济价值.因其分布范围窄、适应性弱、种子萌发率较低,人为破坏严重,使其有濒临灭绝的危险.致其引种、异地保护困难,进一步的开发和利用不能深入进行.珙桐的抗性生理、种子休眠、萌发生理等的研究进展,为珙桐的引种驯化,提高其种子萌发、幼苗成活等提供一定的理论基础.     

运动对GLUT4影响的研究进展

葡萄糖跨膜转运是机体利用葡萄糖的首要步骤。葡萄糖载体(GLUT)是细胞膜上介导葡萄糖跨膜转运的蛋白质,它们对机体的葡萄糖利用有重要意义。运动可有效增加外周组织(主要为骨骼肌和脂肪组织)细胞膜葡萄糖载体4(GLUT4)的数量,使细胞内GLUT4的囊泡数量增多,GLUT4mRNA的表达增强,有效地加快血糖的转移、吸收和利用,解除外周组织胰岛素抵抗,调节血糖平衡,对糖尿病人的治疗有积极的作用和意义。     

我国体育产业发展的双重阻力

我国GDP水平偏低，导致大众体育消费的有效消费不足；体育产业基础薄弱，体育产业结构不合理；体育人口众多与设施场地总量不足的矛盾：是我国体育产业发展的客观阻力。政府在体育产业中的职能定位存在偏差，职能转变缓慢，体育消费市场的实物消费远远大于体育劳务消费，则是我国体育产业发展的主观阻力。提出了在双重阻力作用下我国体育产业发展的思路。     

Physical Inactivity,Obesity, and Type 2 Diabetes: An Evolutionary Perspective

Physical inactivity (and unhealthy nutrition) has distorted body composition and, in turn, reordered the proportions of myocyte and adipocyte insulin receptors. Insulin acting on adipocyte receptors produces less glucose uptake than does comparable interaction with myocyte receptors. Accordingly, in individuals with disproportionate muscle/fat composition, any given glucose load requires greater-than-normal pancreatic insulin secretion for adequate disposal. This hyperinsulinemia then becomes the leading cause of type 2 diabetes (T2DM) as insulin-sensitive tissues become desensitized. Because T2DM is rooted in potentially reversible lifestyle factors, rather than focusing on the intricacies of glucoregulation at the molecular level and on testing new drugs to control blood sugar, this article calls for a new prevention and treatment paradigm, in which exercise and weight control are essential and for which an inexpensive and acceptably accurate measure of body muscle and fat proportions is needed.     

大剂量补充亮氨酸对抗阻运动所致骨骼肌损伤的影响

摘要：目的：探讨补充亮氨酸对无训练史被试进行抗阻运动所致骨骼肌损伤的影响。方法：16名青年男性大学生据体重随机分为补充亮氨酸组与安慰剂对照组,亮氨酸和安慰剂组被试从测试日深蹲抗阻运动前3周直至运动后4 d分别以每千克体重150 mg剂量摄入150 mL亮氨酸或糊精溶液。测试日各组被试以50% 1RM负荷完成5组深蹲运动,每组20次,组间间歇2 min。深蹲运动前于肘正中静脉采集血样,测量大腿围、纵跳高度、膝关节活动幅度与肌肉酸痛程度,并于运动后即刻、24 h、48 h、72 h和96 h重复测试。ELISA法检测血清CK-MM、Mb与血浆IL-6,胶乳增强免疫比浊法检测血清CRP。结果：与安慰剂组被试相比,补充亮氨酸显著降低了亮氨酸组被试运动后延迟性肌肉酸痛水平、大腿中段周长及血清CK-MM、Mb、CRP与血浆IL-6含量,而深蹲1-RM值、纵跳高度及膝关节ROM组间差异则并无统计学意义。结论：1）每千克体重150 mg剂量亮氨酸能够削弱抗阻运动所导致的骨骼肌损伤与疼痛,该效应可能与对炎症反应的抑制有关,且推测亮氨酸对骨骼肌蛋白质代谢平衡的调节作用在其中亦有贡献;2）该剂量亮氨酸不能明显促进工作肌机能恢复。     

全身振动介入抗阻力训练对能量消耗的影响研究

探讨全身性振动介入抗阻力训练对能量消耗的影响,为体重控制及健身减肥者制定有效的运动处方提供依据。方法：以我院体育教育专业健康男性为对象,利用气体代谢分析仪及心率表对"振动介入+抗阻力训练"（实验组,Resistance exercise+Vibration,REV）及单纯"抗阻力训练"（对照组,Resistance exercise, RE）模式下的摄氧及能量消耗等指标进行监测,并运用SPSS17.0对相关指标进行统计分析。结果：1）REV组在训练中及训练后0-25分、25-50分的总每分钟能量消耗及每分钟最大摄氧显著高于RE组;2）抗阻力训练结束后相当长的时间内以脂肪消耗供能为主,表现为REV组脂肪供能比例明显高于RE组;3）抗阻力训练能显著提升训练中呼吸交换率及换气量,表现为REV组提升率高于RE组。结论：全身性振动介入抗阻力训练可比单纯抗阻力增加更多能量消耗,且在训练后恢复期能提升脂肪供能比例,故控体重运动员及健身减肥者将振动作为辅助训练手段是非常有效的。     

The power of circulation: digital technologies and the online Chinese fans of Japanese TV drama

Focusing on the online Chinese fans of Japanese TV drama, this paper explores the way in which the fan subculture, in connection with digital technologies, has carved out alternative practices in the circulation, production and consumption of Japanese TV drama. As ‘minority audiences’ who are not targeted as the objects of capitalist interests, online Chinese fans invent spaces for Chinese transnational networking with self‐help and sharing, as a way of resisting the aloofness from marketing strategies of Japanese TV distributors in Asia. This case study reveals that the online Chinese fan clubs, the websites for downloads, pirated VCD markets, digital file conversion, and private VCD burning – all of these have linked endless networks for the digitalized circulation and consumption of Japanese TV drama. The online Chinese fans are guerrilla fighters in the politics of autonomy, network and low‐cost digital technology; they are attempting to break down time–space constraints and the official distribution hierarchy. Such fan practices shed light on the new trends of audio‐visual consumption via digitalization.