Cell membrane-covered nanoparticles as biomaterials

Surface engineering of synthetic carriers is an essential and important strategy for drug delivery in vivo. However, exogenous properties make synthetic nanosystems invaders that easily trigger the passive immune clearance mechanism, increasing the retention effect caused by the reticuloendothelial systems and bioadhesion, finally leading to low therapeutic efficacy and toxic effects. Recently, a cell membrane cloaking technique has been reported as a novel interfacing approach from the biological/immunological perspective, and has proved useful for improving the performance of synthetic nanocarriers in vivo. After cell membrane cloaking, nanoparticles not only acquire the physiochemical properties of natural cell membranes but also inherit unique biological functions due to the presence of membrane-anchored proteins, antigens, and immunological moieties. The derived biological properties and functions, such as immunosuppressive capability, long circulation time, and targeted recognition integrated in synthetic nanosystems, have enhanced their potential in biomedicine in the future. Here, we review the cell membrane-covered nanosystems, highlight their novelty, introduce relevant biomedical applications, and describe the future prospects for the use of this novel biomimetic system constructed from a combination of cell membranes and synthetic nanomaterials.     

网络关系强度与企业技术创新关系实证研究

网络关系强度是企业技术创新过程中需要考虑的重要因素。在回顾已有文献的基础上,构建了网络关系强度、时间节奏、环境动态性和企业技术创新四者之间的理论模型,以珠三角地区企业为研究对象并进行了实证检验,结果表明:(1)强关系、弱关系对渐进式创新和突破式创新均有显著正向影响。(2)时间节奏在强关系、弱关系与渐进式创新关系中以及在强关系与突破式创新关系中均发挥了完全中介作用,在弱关系与突破式创新关系中发挥了部分中介作用。(3)环境动态性在弱关系与突破式创新关系中具有显著的正向调节作用。     

环境工程大学生创新能力及课程设置探索

讨论了为提高环境工程专业大学创新能力而进行的课程体系设置改革的问题.基于对环境工程专业特点的认识,讨论了对环境工程专业大学生创新能力的要求,提出了改革本专业课程体系的基本原则,并认为不同学校可以为形成自己的专业特色而有较大的差别.     

An improved method for computing Hankel transform

The purpose of this paper is to compute the Hankel transform F_n(y) of order n of a function f(x) and its inverse transform using rationalized Haar wavelets. The integrand is replaced by its wavelet decomposition. Thus representing F_n(y) as a Fourier-Bessel series with coefficients depending strongly on the local behavior of the function , thereby getting an efficient algorithm for their numerical evaluation. Numerical evaluations of test functions with known analytical Hankel transforms illustrate the proposed algorithm.     

西方国家建立社会保障制度时机选择对我国的启示

完善的社会保障制度是社会和谐发展的客观基础与必要条件。我国已经进入经济社会发展转型和人口转型的特殊阶段,建立普惠型社会保障制度刻不容缓。历史经验表明。西方社会保障发达国家之所以在某个关键时期选择建立或完善社会保障制度．就是因为社会保障不仅对社会发展具有积极的指引作用,还能有效地促进和推动经济健康发展。作为一个快速发展的工业化国家。我国只有建立起健全、完备的社会保障制度,来解决老百姓的各种生活后顾之忧。社会才能实现和谐,经济才能持续发展,文明才会不断进步。而当前正是推动我国建立普惠型社会保障制度的良好时机。     

机械制造企业的生产能力及能力计划研究

本文从技术的角度出发，分别研究了宏观和微观两种情况下，生产过程中各因素对生产能力的贡献，以及它们综合作用的效果，进而形成生产能力的定义，明确了提高生产能力必须处理的两个关键问题，最后用基于优先等级的方法来解决CIMS下能力需求计划的制定问题。     

The effect of periodized resistance training on accelerative sprint performance

The purpose of this study was to assess the effect of periodized resistance training on accelerative sprint performance. Sixteen physically active men participated in a randomized controlled study. An experimental group (n = 10) completed an 8-week periodized resistance training intervention, while a control group (n = 6) did not train. Pre- and post-training measures of 20-m straight-line sprint time, including a 10-m split, maximum strength, and explosive strength, were recorded. Flight time, stance time, stride length, and stride frequency were quantified from digitized video recordings of the first three strides of the 20-m sprint. Resistance training resulted in significant increases in maximum strength (parallel back squat: 19%) and explosive strength (6–10%). However, both groups increased 0–10 m sprint times (experimental group = 6%; control group = 3%) while 10–20 m times were reduced (experimental group = 7%; control group = 4%), highlighting the mechanical differences between the distinct sprint phases. The change during the 0–10 m interval was accompanied by a reduction in stride frequency during the first three strides. Strength coaches should be aware that the potential benefits of increased muscular strength during short sprints are likely to be affected by mechanical specificity and that improvements in sprinting performance may not occur immediately after a period of resistance training.     

医学科普文章标题的时代特征分析

通过统计1983、1988、1993、1998和2001年<家庭医生>发表文章的标题的变化,分析医学科普文章标题的时代特征,认为医学科普文章的标题应适应时代的变化.     

西亚北非局势动荡与大学生国情教育

近期,西亚北非多个国家发生局势动荡,一些国家的青年大学生在动荡中扮演了主要角色。必须加强对中国大学生国情教育,抵制西亚北非外溢效应的影响。本文阐述了当前大学生国情教育必须把握的四个关键问题：第一,中国发展的成就大于存在的问题;第二,稳定发展才能解决中国的问题;第三,中国与西亚北非的根本区别;第四,中国发展要抓住重要的战略机遇期。     

基于Q-learning的飞行自组织网络QoS路由方法

针对无人机自组网等高动态飞行自组织网络中,网络拓扑的快速变化导致通信链路断裂和路由重建频繁的问题,研究一种基于Q-learning的QoS(quality of service)路由方法.该方法以Q-learning强化学习框架为基础,将邻居节点数量、链路持续时间和链路可用带宽作为路由度量信息,设计一种提供QoS保证的...