高效液相色谱在生化药物分析中的应用与展望

高效液相色谱因为其独特的优势,在药物分析上有着巨大的作用。文章综述了近年来国内外学者对于高效液相色谱在生化药物分析中的应用进展,简述了一些新的方法和新的应用。     

槟榔嚼块对神经系统的影响及其依赖性

槟榔嚼块（betel quid）是一种由槟榔果和多种添加物组成的混合物,含有槟榔碱、槟榔次碱、去甲槟榔次碱等多种生物碱,对中枢和外周神经系统均产生明显的药理作用,具有一定的滥用潜力和依赖性。     

印尼正规小学华文教材使用及本土华文教材编写现状研究

本文通过实地调查、访谈以及文献研究等方式考察和分析了印尼小学华文教材的使用情况,指出了印尼小学在教材使用及编写上存在的问题,并依此提出相应的解决对策,以期提高教材使用及编写的效果,促进华文教学的发展。     

安阳市高新区城乡结合部土地利用结构浅析

以安阳市高新区为例,选取1996,2007和2009年3个年段,从土地利用结构现状及存在问题入手,进行了土地利用结构变化实例分析;初步总结了高新区在土地利用中存在的一些问题,并有针对性地提出了相关建议。     

基于ARM的电机动态参数检测与处理系统设计

电机运行时会产生各种电磁和共模干扰,影响电机参数的准确获取。传统的电机参数检测方法不能充分滤除现场出现的各种干扰信号,从而增大测量误差,影响测量参数的准确性。为此,本文设计了一种实用的干扰抑制技术,大大提高了测量参数的准确性和精确性。最后通过GSM／GPRS无线网络数字传输技术,将下位机采集到的电机参数发送给上位机中心专家诊断端系统,进行在线实时故障诊断和排除。     

Response and interventions into harmful sexual behaviour in schools

Internationally young people report experiencing sexual abuse and violence within schools. Developments within the field of adolescent sexual harm are increasingly recognising the need for ecological approaches to harm. Yet, to date, interventions with young people displaying harmful sexual behaviours have prioritised individual behaviours and characteristics over place-based interventions.This article presents empirical evidence from a mixed-methods study aimed at understanding the enablers and barriers to preventing and responding to harmful sexual behaviour in schools. Research was carried out in seven schools and four multi-agency partnerships in England, UK. Using evidence from focus groups, observations, case reviews and policy analysis the article outlines nine components that enable, or are barriers to, effective responses and interventions into harmful sexual behaviour in schools. The paper concludes that responses and interventions into harmful sexual behaviour must move beyond responding to individual behaviours to intervening within factors within schools themselves.     

Professionals’ preferences and experiences with inter-organizational consultation to assess suspicions of child abuse and neglect

This study addresses the following questions in cases of suspected child abuse and neglect (CAN) in children up to four years of age: 1) How many professionals intend to seek inter-organizational consultation? 2) What types of organizations do professionals prefer to consult? and 3) What factors can be identified as facilitator(s) or barrier(s) regarding inter-organizational consultation, based on professionals’ experiences? Professionals working with children in 101 organizations in a medium-sized Dutch city were invited to fill in an online questionnaire. The questionnaire included a vignette about a suspected case. Quantitative, qualitative, and social network analysis approaches were used to analyze the data. Seventy-eight questionnaires were available for analysis. Fifty-five respondents (71%) intended to seek inter-organizational consultation. Ten different organization types were mentioned. The most frequently mentioned organization was preventive child healthcare. In total, 82 text fragments from 39 participants were available to analyze barriers and facilitators to inter-organizational consultation, 60 fragments that entailed a facilitator and 22 fragments that entailed a barrier. The text fragments were subdivided into twelve factors. The three factors that were most often identified as a facilitator were ‘support’, ‘undertaking action’, and ‘regard’. Barriers were found in relation to all twelve factors. No specific barrier(s) stood out. This study demonstrated that most professionals are inclined to seek inter-organizational consultation when they suspect CAN. They are especially likely to seek consultation from preventive child health care organizations. Their experiences mainly revealed facilitators and few barriers. The implications for research and practice are also discussed.     

The association between perceived injunctive norms toward corporal punishment,parenting support,and risk for child physical abuse

The use of corporal punishment (CP) is a strong risk factor for many poor outcomes for children including child maltreatment. The use of CP occurs within social contexts which are important to understand. Although it is known that perceived social norms regarding CP are related to its use, the specific role that a mother’s primary support person plays in influencing attitudes toward and use of CP remains unknown. The current study assessed linkages between maternal perceived social support in parenting and perceived injunctive norms of CP from her primary source of support, with maternal attitudes toward and use of CP. Survey data were collected from female primary caregivers (N = 436) of children age 2 to 7 years (mean age = 3.7) enrolled in Special Supplemental Nutrition Program for Women, Infants and Children (WIC) clinics in Southeastern Louisiana. Most frequently, the biological father of the child (37.9%) and the maternal grandmother of the child (24.2%) were identified as the participant’s primary source of social support in parenting. Perceived injunctive norms of this support person toward CP use were significantly and positively associated with attitudes toward, AOR = 5.97, 95% CI = [4.04, 8.82], and use of CP, AOR = 3.77, 95% CI = [2.55, 5.59]. However, perceived social support was not associated with these outcomes and also did not moderate these associations. Findings suggest that efforts to reduce maternal risk for child physical abuse and use of CP must include the mother’s primary source of social support if they are to be successful.     

From childhood emotional maltreatment to depressive symptoms in adulthood: The roles of self-compassion and shame

BackgroundEmotional abuse is a form of maltreatment that most strongly predicts adult depressive symptoms in community samples. Introject theories suggest that some depressive symptoms stem from survivors having learned to treat themselves the way they were treated by their perpetrators.ObjectiveMalevolent introjects may undermine self-compassion, which may subsequently maintain feelings of shame. Thus, we hypothesized that self-compassion and shame would mediate the path from retrospective reports of maltreatment to concurrent depressive symptoms in adulthood.Participants and SettingParticipants were 244 adult community members and college students living in a Southwestern American metroplex.MethodWe ran a multiple mediator path model with emotional abuse as the independent variable. We specified four covariates: physical abuse, sexual abuse, physical neglect, and emotional neglect, and held constant the variance they explained in self-compassion, shame, and depression.ResultsOur final model accounted for 53.1% of the variance in adult depressive symptoms. A significant indirect effect from emotional abuse passed through both mediators and ended in adult depressive symptoms. We also found an indirect path from emotional neglect to depression passing through both mediators.ConclusionsIt appears emotional abuse and emotional neglect can undermine the formation of self-compassion. Low self-compassion predicts greater shame and depressive symptoms. Our model suggests self-compassion may be a particularly effective intervention point for survivors of emotional maltreatment.     

基于B/S模式的机械类金工课程网络教学平台的建设

金工课程是机械大类的专业基础课,理论性、实践性和工艺性都很强,学习方法不易掌握.针对这一情况研究开发的机械类金工课程网络教学平台,旨在较好地帮助提高教与学的质量和效率,有效改善教学效果.