Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Discrete Choice Modeling in Education: An Innovative Method to Assess Teaching Practices

Self‐reported measures are an easy, time‐efficient, and low‐cost way to collect research data compared to other assessment methods. They are, however, characterized by several limitations regarding the quality and the clarity of the data they produce, especially when they are implemented in education. The main purpose of the current study was to use a method called discrete choice modeling (DCM) in education, in order to develop a self‐reported instrument that will reduce the bias for socially desirable responses and to assess teachers’ practices in physical activity. DCM method has the ability to overcome the respondents’ tendency to answer in a socially desirable way. A nationally representative sample of 531 Greek early educators participated in this study and were administered a self‐assessment questionnaire based on DCM. Results showed that the DCM based newly developed instrument manages to assess effectively educators’ practices and provided evidence of the applicability of the method in education. Further implications and future recommendations regarding the effective application of DCM in education are discussed.     

Evaluating the international dimension in an undergraduate curriculum by assessing students’ intercultural sensitivity

This formative, outcome-oriented, theory-based evaluation research study assessed the effectiveness of requiring an international (‘I’) course by measuring students’ intercultural sensitivity (IS) at the start and end of a semester. Findings revealed that students’ IS scores did not change regardless of the type of class in which the student was enrolled and were not significantly different based on gender, age, ethnicity, undergraduate classification, or number of ‘I’ courses taken. There were significant differences in IS based on religion, traveling outside the US, participating in a study abroad course, and the number of cultural events in which the student had participated. Regression analysis confirmed that religious affiliation and number of times traveled outside the US were significant predictors of IS. This study is an example of the use of theory-based evaluation in an educational system and provides important insights into what experiences affect college students’ IS.     

高职院校顶岗实习管理机制构建探析

顶岗实习是实现高职人才培养目标的重要途径。鉴于当前高职顶岗实习中学校、学生及教师各层面都存在的问题,重新设计了顶岗实习的流程体系,通过校、企、师、生、家五方联动,构建了五途径保障实习岗位、两维度驱动实习成效、四层次规范实习管理、三主体强化实习评价的“五二四三”顶岗实习模式,实现学生、企业、教师、家长、导师和学校的六方共赢。     

下一代图书馆系统平台的实践与思考

[目的/意义]大数据与人工智能等技术为图书馆智慧服务带来机遇与挑战，图书馆新系统平台建设刻不容缓。旨在探讨下一代图书馆系统平台发展现状及对策，为建设一流高校智慧图书馆提供实践案例与参考依据。[方法/过程]梳理图书馆系统平台发展脉络，在盘点现有的国内外下一代图书馆系统平台的研究与实践的基础上，以南京大学为例，探索图书馆新系统平台的建设方案。[结果/结论]智慧图书馆将通过建设一体化电子资源管理平台并打造NLSP，提升图书馆资源管控和知识服务水平，构建开放共享的智慧图书馆服务体系。     

图书情报学领域学科交叉及其国家差异的动态分析

[目的/意义]领域知识的跨学科交叉研究能够打破学科间的壁垒,有助于发现重大科学问题的解决方案。[研究设计/方法]基于图书情报学领域文献题录信息构建轻量级领域知识图谱,从中提取学科信息、国家信息、时间信息及其关联,采用时间与空间相结合的多维度分析方法,对学科交叉的演化进程以及国家差异进行跟踪与分析。[结论/发现]图书情报学领域内学科交叉现象日渐显著,各国家的学科交叉程度与倾向存在差异,一些目前尚不突出的交叉学科方向值得关注。[创新/价值]采用多维度视角分析学科交叉现象,相关结论可以为国家科技战略制定及学科发展规划提供有益参考。     

消费时代澳门半岛滨水空间形态重塑

随着消费社会的深化发展,现代消费已成为影响城市空间形态演化的重要因素。以此为出发点,以消费文化的视角来考察城市空间,揭示20世纪80年代以来澳门半岛滨水空间形态的演化特征。研究表明:消费时代,城市主要根据经济诉求组织空间的生产,借助资本的熔铸,澳门半岛滨水空间建设呈现出博彩旅游化、高层豪宅化和空间巨构化等特征,并最终实现空间形态的重塑。在此基础上进行批判性反思,如城市消费空间与传统城市意象的协调发展、城市空间的阶级化和滨水空间的公共性等问题。     

锻炼与针刺组合对退行性膝关节炎微循环血流灌注量的影响

目的：锻炼与针刺组合对退行性膝关节炎微循环血流灌注量的影响。方法：研究对象40例随机分为2组，分别是针刺组（单纯针刺）和锻炼组（站桩与针刺组合），对其实验前后疼痛程度（VAS）、微循环血流灌注量（MBPU）及皮肤温度的变化进行检测分析。结果：两组实验后，VAS评分明显降低（P<0.01），锻炼组优于针刺组（P<0.05）；MBPU降低（P<0.01），锻炼组优于针刺组（P<0.05）；局部温度明显提高（P<0.05）。结论：锻炼与针刺组合可以明显缓解退行性膝关节炎的疼痛症状，降低局部微循环血流灌注量，提高皮肤温度；优于单纯针刺疗法。     

中国共产党领导下的大连福岛纺织株式会社工人大罢工

1926年4月27日,因无法忍受日本资本家的残酷压榨和剥削,大连福岛纺织株式会社1000余名工人举行了声势浩大的罢工。罢工过程中,日本资本家采取了种种惨无人道的压迫手段逼迫工人复工。在中国共产党的领导下,工人们团结一致,坚定信念,最终取得罢工斗争的胜利,充分展示了中国工人阶级的强大力量,而中国共产党的领导对此次罢工的胜利起到了决定性的作用。     

大学生孤独感对手机成瘾倾向的影响:生命意义感的调节作用

为了探究大学生孤独感、手机成瘾倾向和生命意义感之间的关系,采用UCLA孤独量表、大学生手机成瘾倾向量表、人生意义感问卷,选取408名大学生作为被试进行问卷调查。结果发现:(1)孤独感与手机成瘾倾向呈显著性正相关,生命意义感与手机成瘾倾向呈显著性负相关,孤独感和生命意义感相关性不显著;(2)孤独感和生命意义感都显著预测手机成瘾倾向,生命意义感在孤独感和手机成瘾倾向之间的调节效应显著,低生命意义感大学生的孤独感对手机成瘾倾向的预测力更强。因此,大学生的孤独感能正向预测手机成瘾倾向,生命意义感能调节二者之间的关系,低水平的生命意义感会加剧孤独感对手机成瘾倾向的预测作用,而高水平的生命意义感会使孤独感对手机成瘾倾向的影响较小。