Reliability of arterial spin labelling measurements of perfusion within the quadriceps during steady-state exercise

Arterial spin labelling (ASL) provides a potential method to non-invasively determine muscle blood flow and examine the impact of interventions such as supplementation and training. However, it's a method with intrinsically low signal, leading to limitations in accuracy and temporal resolution. To examine these limitations, the current study measured perfusion via ASL on three occasions in the rectus femoris of 10 healthy adults, during light and moderate exercise, over three different exercise durations. For data sampled over 9 min, light intensity exercise gave an average perfusion of 35.0 ± 5.1 ml/min.100g^?1 with a coefficient of variation (COV) of 16% and single intraclass correlation coefficient (ICC) of 0.67. For the moderate bout, perfusion was 51.3 ± 5.6 ml/min.100g^?1 (COV 10%, ICC 0.82). When the same data were analyzed over 5 min 24 s, perfusion was 37.8 ± 11.13 (COV 30%, ICC 0.13) during light and 49.5 ± 8.8 ml/min.100g^?1 (COV 18%, ICC 0.52) during moderate exercise. When sampling was reduced to 1 min 48 s, perfusion was 41.2 ± 13.7 (COV 33%, ICC 0.26) during light and 49.5 ± 13.6 ml/min.100g^?1 (COV 28%, ICC 0.04) during moderate exercise. For 9 min a significant perfusion difference was found between the exercise intensities; however, this was not the case for sampling over 5 min 24 s or 1 min 48 s. Such findings illustrate the potential of ASL to non-invasively monitor muscle perfusion under steady-state conditions, but highlight that extended exercise protocols are necessary in order to generate date of sufficient reliability to be able to discriminate intervention dependent perfusion differences.     

吸血蛭与非吸血蛭间的氨基酸比较研究

为探究传统中药水蛭的药用成分，更好地开发利用蛭类资源，本文通过高效氨基酸分析仪，分析了云南四种蛭类的氨基酸组成．结果表明吸血蛭与非吸血蛭在氨基酸组成上有明显差异．结合以往实验，分析了非吸血蛭活血化瘀的可能药用成分，为合理开发利用蛭类资源提供了资料和建议．     

便携式多参数监护仪的研制

本介绍了一种便携式人体多参数监护仪的研制方法，包括：心电检测、血压检测、血氧饱和度检测、呼吸检测模拟电路的设计，以及存储单元、A／D转换器、USB通讯口等接口模块的设计。     

凉血活血中药治疗重度黄疸型肝炎的疗效观察

目的:观察大剂量凉血活血中药对重度黄疸型肝炎的疗效;方法:将重度黄疸型肝炎随机分为治疗组和对照组,治疗组除常规使用西药护肝外加用大剂量凉血活血中药(大黄、丹参、赤芍等)治疗,与常规西药护肝治疗对照;结果:治疗组退黄降酶总有效率为88.89％,优于单用西药护肝组(58.46％),P<0.01。结论:大剂量凉血活血中药结合常规西药护肝治疗重度黄疸型肝炎对于退黄、降酶的疗效明显优于单用西药治疗,且无明显副作用。     

改进血型实验方法,培养学生综合能力

改进血型定性实验为综合性实验,试制血型诊断抗体和诊断红细胞悬液,满足中学生血型实验试剂需求。自正常A、B型血样分离血清或红细胞,玻片法定性倍比稀释定量检测抗A、抗B,滤菌后冷藏;生理盐水洗涤红细胞,离心沉淀,冷藏。用自制诊断抗体和诊断红细胞悬液与标准试剂对比检测样本60例。自制诊断抗体与诊断红细胞悬液的诊断结果与标准试剂无显著性差异。大学生自制诊断抗体与诊断红细胞悬液基本达到生物制品诊断试剂的标准,大大降低学校用血型试剂成本,也有利于培养大学生综合技能。     

鱼类与哺乳类血液及循环生理比较之浅见

就鱼类与哺乳类在血液及循环生理方面作一简单比较．     

246例体检儿童超重或肥胖与血脂异常调查

目的调查苏北地区儿童的体质指数(BMI)水平和血脂水平,探讨儿童的超重或肥胖与血脂异常的关系。方法统计分析246例体检儿童的BMI指数和血脂水平,以BMI指数水平将246例体检儿童分为正常组和超重或肥胖组,比较两组间多种血脂水平异常的发生率。结果本地区儿童的血脂水平:TC 3.65±0.61 mmol/L,TG 0.96±0.41mmol/L,LDL-C 1.82±0.57 mmol/L,HOL-C 1.47±0.32 mmol/L。BMI水平17.1±2.5。超重或肥胖组血脂异常的发生率:TC 20.0%,TG 53.3%,LDL-C 33.3%,三种血脂水平异常的发生率均显著高于正常组(P<0.01)结论在进行心脑血管疾病早期预防时,应将肥胖或超重儿童这一群体作为重点干预对象,积极预防和治疗肥胖或超重儿童的血脂异常。     

张承志小说宗教情结的文学表述

张承志的宗教情感来自于民族血脉和对伊斯兰坚忍不屈的感动。由于是在汉文化背景下长大的作家，他的初期创作受不同宗教思想的影响，经历了文化追寻后，找到了精神故乡皈依了伊斯兰。文学和宗教有许多共同之处，《心灵史》实现了文学和宗教的联姻。新时期的文学宗教热，表现了对人生意义和价值的文化思考。     

Study of Resistin gene expression in peripheral blood mononuclear cell and its gene polymorphism in a small range population

INTRODUCTION Recently discovered as an endocrine organ, adi-pose tissue can secrete many cytokines such as Re-sistin, adiponectin and free fatty acids, and receives much attention in the study of insulin resistance and type 2 diabetes mellitus (T2DM). As a peptide hor-mone secreted by adipocyte, Resistin is considered to be the linkage between obesity and insulin resistance (Steppan et al., 2001). Most studies on Resistin in-vestigate adipose tissue. In this experiment we de-tected t…     

The Role of History and Ethics of Anatomy in Medical Education

While time spent on anatomical education in medical school curricula has been diminishing over the last decades, the recognized role of anatomical dissection has expanded. It is perceived by many students and faculty not only as the means of learning the structure and function of the human body, but also as an opportunity for the acquisition of professional competencies such as team work, patient–doctor interaction, medical epistemology, self-awareness, and an understanding of medical ethics. This viewpoint article proposes that this learning process can be supported effectively through studying examples from the history of anatomy, as insights from this history can help illuminate contemporary ethical issues in anatomy and medicine. Anatomical education can thus provide not only the opportunity of gaining awareness of ethical questions, but also a chance to practice these new insights within the protected environment of the laboratories, in interaction with the dead and the living. Consequently, a new role has developed for anatomists, which includes the interweaving of the scholarly exploration of the history and ethics of anatomy with the practical application of research results into a reframed concept of anatomical education. Anatomy, as a foundational discipline in the medical curriculum, can thus provide a first step on the educational path of empathetic and humane medical caregivers.