More Than Just a Student Voice: Facilitating Student Leadership Development Through the Library Student Liaison Program

This article explores how the library-student liaison program at Eastern Washington University (EWU) Libraries has evolved into an opportunity for students to develop leadership skills. Originally designed to foster better communication between the EWU Libraries and students enrolled at the university, we recognized that the process of achieving established goals for the program provided a vehicle for students' leadership-skill development. To facilitate the leadership process, librarians employed the Social Change Model. Designed specifically for college students, this model engages the student to develop individual capacities to strengthen group activities that foster positive changes in the community and society.     

电子健康网站用户信息披露行为影响因素研究

[目的/意义]旨在确定信息披露行为影响因素,优化电子健康网站生态环境,间接助力"健康中国2030"战略目标的实现。[方法/过程]采用质性研究方法,对访谈资料进行三级编码,抽取影响电子健康网站用户信息披露的17个主范畴及5个核心范畴,并构建电子健康网站用户信息披露行为影响因素模型。[结果/结论]电子健康网站用户信息披露行为主要受到用户感知效用、感知风险、主观规范、服务质量和病情特征影响。其中,感知效用是最重要影响因素,感知风险是次重要影响因素,主观规范是较重要影响因素,服务质量和病情特征是相对不重要影响因素。据此,从政府部门、电子健康网站和用户3个维度,总结相关启示。     

Why Users Share the News: A Theory of Reasoned Action-Based Study on the Antecedents of News-Sharing Behavior

Social media have become an integral part of online news use, affecting how individuals find, consume, and share news. By applying the Theory of Reasoned Action (TRA), this study investigates the effects of motives, attitude, and intention on news-sharing behavior among German social media users (n = 333). Findings show that news-sharing attitude and subjective norms have a positive effect on news-sharing intention, which in turn has a positive effect on actual news-sharing behavior. Taken together, we see that a new media behavior in the early phases of its societal diffusion—like social media news sharing in Germany in 2015—can mainly be explained by a rational choice logic and is rooted in the motives of socializing and information seeking. This finding thus reflects the double nature of social media as a means for both information retrieval and social grooming.     

Managing a Biomedical Library’s Instruction Program: Redefining Scope

The National Institutes of Health (NIH) library instruction program provides training services to staff, clinicians, and researchers across NIH and several Department of Health and Human Services (HHS) operating divisions. The audience, training needs, and training topics are diverse and constantly changing. The NIH library has developed several new services and class topics to meet the needs of its NIH and HHS communities. Context, strategies, and future directions for the NIH library instruction program are described.     

Health science libraries in Sweden: new directions,expanding roles

Librarians in Sweden are facing huge challenges in meeting the demands of their organisations and users. This article looks at four key areas: coping with open science/open access initiatives; increasing demands from researchers for support doing systematic reviews; understanding user experiences in Swedish health science libraries; and the consequences of expanding roles for recruitment and continuing professional development. With regard to changing roles, there is an increasing shift from the generalist towards the expert role. The authors raise the issue as to how to prepare those new to the profession to the changing environment of health science libraries.     

Combination of Se-methylselenocysteine,D-α-tocopheryl succinate, β-carotene,and L-lysine can prevent cancer metastases using as an adjuvant therapy

ObjectivePrimary tumor treatment through surgical resection and adjuvant therapy has been extensively studied, but there is a lack of effective strategies and drugs for the treatment of tumor metastases. Here, we describe a functional product based on a combination of compounds, which can be used as an adjuvant therapy and has well-known mechanisms for inhibiting cancer metastases, improving anti-cancer treatment, and enhancing immunity and antioxidant capacity. Our designed combination, named MVBL, consists of four inexpensive compounds: L-selenium-methylselenocysteine (MSC), D-‍α‍-tocopheryl succinic acid (VES), β‍-carotene (β‍-Ca), and L-lysine (Lys).MethodsThe effects of MVBL on cell viability, cell cycle, cell apoptosis, cell migration, cell invasion, reactive oxygen species (ROS), and paclitaxel (PTX)-combined treatment were studied in vitro. The inhibition of tumor metastasis, antioxidation, and immune enhancement capacity of MVBL were determined in vivo.ResultsMVBL exhibited higher toxicity to tumor cells than to normal cells. It did not significantly affect the cell cycle of cancer cells, but increased their apoptosis. Wound healing, adhesion, and transwell assays showed that MVBL significantly inhibited tumor cell migration, adhesion, and invasion. MVBL sensitized MDA-MB-231 breast cancer cells to PTX, indicating that it can be used as an adjuvant to enhance the therapeutic effect of chemotherapy drugs. In mice, experimental data showed that MVBL inhibited tumor metastasis, prolonged their survival time, and enhanced their antioxidant capacity and immune function.ConclusionsThis study revealed the roles of MVBL in improving immunity and antioxidation, preventing tumor growth, and inhibiting metastasis in vitro and in vivo. MVBL may be used as an adjuvant drug in cancer therapy for improving the survival and quality of life of cancer patients.     

Transportation of AIE-visualized nanoliposomes is dominated by the protein corona

Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of nanomaterials, once liposomes are incubated in a biological milieu, their surface can be immediately cloaked by biological components to form a protein corona, which confers a new ‘biological identity’ and modulates downstream interactions with cells. However, it remains unclear how the protein corona affects the transportation mechanism after liposomes interact with cells. Here, we employed home-made aggregation-induced-emission-visualized nanoliposomes TR4@Lipo as a model to investigate transportation with or without the protein corona by optical imaging techniques. The results show that the protein corona can change the cellular transportation mechanism of TR4@Lipo from energy-independent membrane fusion to energy-dependent endocytosis. The protein corona also modulates the intracellular distribution of loaded cargoes. This knowledge furthers our understanding of bio-nano interactions and is important for the efficient use of cationic liposomes.     

一种基于视频的DEW水印算法

采用差分能量水印(DEW)算法,对视频数字作品进行了数字水印的嵌入、检测和提取研究。实验结果表明,该算法计算简单、速度快、易于实现,视频信号里可编码的数据量大,可以隐藏较多的信息,并且还可以满足水印的实时嵌入和提取。