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Fadhaa A. Ghafil Bassim I. Mohammad Hussain S. Al-Janabi Najah R. Hadi Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81
Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses. 相似文献
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袁秋凤 《宁德师专学报(自然科学版)》2011,23(2):164-167
Proteus和Keil作为单片机系统开发的主流工具,具有节约硬件成本、缩短研发周期、提高设计成功率的特点.以AT89C52、DS1302和LCD1602为主要元器件,设计和仿真一个数字电子钟系统. 相似文献
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介绍AT45DB161大容量SPI串行FLASH存储器在PHILIPS的ARM7系列单片机LPC213X/214X中的应用,重点介绍硬件电路设计及软件编程方法。 相似文献
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基于STC89C55,使用模拟调频技术,设计了一种单工无线呼叫数据传送系统,在30~40 MHz频段上,实现了话筒输入和线路输入语音信号的小功率远距离单工发送和接收.其数据通信采用FSK调制方式,主、从机可实现智能控制通信,可连接多达256个从站,构成一点对多点的单工无线呼叫系统. 相似文献
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在物理学及电子学的研究过程中,经常要对运动物体经过某两点的时间间隔进行测量,以研究物体在整个运动过程中的状态或规律。研究自由落体运动时需测量物体经过相等距离的相邻两点之间的时间间隔;研究刚体转动惯量时需测量扭摆装置两次经过光电门的时间间隔,研究动态电路时也经常要测量两个状态之间的时间间隔。从测量时间间隔的范围看,大的到小时、几天甚至更大,小的到秒、毫秒、微秒甚至更小。文章以AT89S52单片机为核心,对时间间隔测量仪从硬件及软件两方面进行了研究设计,并在实践中得到了验证。 相似文献
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通过实例详细介绍了Authorware与单片机进行多机通讯的原理和方法,既有硬件原理图,又有程序清单,具有一定的实用价值. 相似文献
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本文设计的数字电压表具有高精度、低成本和便携的特性。使用ADC0809作为A/D转换芯片,能将模拟电压信号通过逐次比较的方式输出8位二进制;通过AT89S52对其进行处理,转换为十进制数,由LCD1602液晶显示出数字电压;利用+9V蓄电池与LM7805组成稳压电路,保证系统电源为+5V稳定输入;设计的数字电压表能测量一路0~+5V的电压,精度为0.020V。 相似文献
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霓虹灯控制器由于应用广,故追求较高的性价比。由AT89C51单片机结合双向晶闸管输出型的光电耦合器MOC3021来实现的控制器功能,时间常数易修改,使用灵活,电路易实现,成本低,控制芯片更换方便。 相似文献