胰腺巨大实性假乳头状瘤1例

报道了完整切除1例5.5kg重的巨大实性假乳头状瘤.病理诊断:胰腺实性假乳头状瘤,浸润包膜,低度恶性.     

原来,手术这么痛苦

你们千万不要误会啊,我从小到大,一次手术都没有做过哦!但是前几天,我老爸做了阑尾切除手术,光听大伙的口头叙述,我就全身起鸡皮疙瘩了,但他们还说这是手术中最简单的一种!我差点就瘫在了地板上……     

对流行健康理念的颠覆

新谷弘实,现居纽约,美国最权威的内视镜外科医师;在医学界首次利用新谷式大肠内镜插入法,不开腹而直接将内视镜深入患者肠胃并成功切除肿瘤,为医学界做出了巨大贡献:曾经在日本利用大肠内视镜诊断了大约三十万例肠胃病患者,并且对九万多名患者成功实施了肿瘤切除手术,在医学界成为这一领域的权威.     

辽东楤木对过度训练大鼠肝脏氧化损伤的预防作用

目的:以大鼠因过度训练而造成的机体损伤为模型,观察辽东楤木提取物对大鼠肝组织脂质过氧化、超氧化物歧化酶(SOD)活性和血清谷丙转胺酶(GPT)活性的影响。方法:将雄性Wistar大鼠随机分4组,即安静对照组(A)、运动组(B)、楤木低剂量加运动组(D)、楤木高剂量加运动组(E)。将大鼠按训练计划进行6周的游泳训练,并对D、E组分别灌服低、高剂量辽东楤木提取物,最后测定MDA含量、GPT活性及SOD活性。结果:过度训练后大鼠肝组织MDA含量和血清GPT活性显著上升(P<0.05),肝组织中SOD活性显著下降(P<0.05),而低剂量楤木提取物可显著抑制这种趋势的发生(P<0.05)。高剂量楤木提取物的作用效果不明显。结论:低剂量辽东楤木提取物对过度训练后大鼠肝脏的氧化损伤具有一定的预防作用。     

A novel way of liver preservation improves rat liver viability upon reperfusion

Background/aim： Currently, the liver is cold-preserved at 0-4 ℃ for experimental and clinical purposes. Here, we investigated whether milder hypothermia during the initial phase of the preservation period was beneficial for liver viability upon reperfusion. Methods： In the first set of experiments, rat livers were preserved either conventionally in clinically used histidine-trypthopan-ketoglutarate （HTK） solution （Group A： 45 min and Group B： 24 h） or by slow cooling HTK solution （from 13 ℃ to 3 ℃） during the initial 45 min of preservation （Group C： 24 h）. In the second set of experiments, additional groups of livers were evaluated： Group BB-preservation according to Group B and Group CC-preservation according to Group C. Further, some livers were preserved at 13 ℃ for 24 h. Livers were then reperfused using a blood-free perfusion model. Results： Bile production was approximately 2-fold greater in Group C compared to Group B. Alanine transaminase （ALT） and aspartate transaminase （AST） release into perfusate were 2-3-fold higher in Group B compared to Group C. No significant differences were found in ALT and AST release between Group C and Group A. Livers in Group CC compared to Group BB exhibited significantly lower portal resistance, greater oxygen consumption and bromosulfophthalein excretion into bile and lower lactate dehydrogenase （LDH） release into perfusate. Histological evaluation of tissue sections in Group BB showed parenchymal dystrophy of hepatocytes, while dystrophy ofhepatocytes was absent in Group CC. Livers preserved at 13 ℃ for 24 h exhibited severe ischemic injury Conclusion： These results suggest that the conventional way of liver preservation is not suitable at least for rat livers and that slow cooling of HTK solution during the initial phase of cold storage can improve liver viability during reperfusion.     

雌激素与阿尔茨海默病大鼠发病机制的关系

目的:采用双侧卵巢切除的方法制作阿尔茨海默病(Alzheimer,disease AD)模型,观察AD模型大鼠脑内皮层区,海马CA1区,杏仁复合体区和Meynert核区酪氨酸激酶原癌基因(tyrosine kinase proto-onco-geneA,TrkA)的表达与对照组比较有何变化,以探讨雌激素的变化与AD发病机制的关系。②方法:取健康雌性Wistar大鼠20只,随机分成四组,每组各5只;对照组;卵巢切除组(去势组);在脑立体定位仪上,切除大鼠双侧卵巢,建立模拟AD的动物模型。应用免疫组织细胞化学技术对trkA免疫阳性细胞染色。观察AD模型组大鼠脑皮层区,海马CA1区,杏仁复合体区和基底前脑Meynert核区等部位trkA阳性细胞的表达与对照组比较是否不同。③结果:对照组大鼠脑内的各观察区内trkA表达无明显改变;AD模型组大鼠脑内的皮层区,海马CA1区,杏仁复合体区和基底前脑Meynert核区trkA的阳性细胞显著减少(P<0.05)。④结论:AD模型组大鼠脑内皮层区,海马CA1区,杏仁复合体区和基底前脑Meynert核区内trkA的阳性细胞显著减少,提示雌激素缺乏使trkA的表达减少可能与老年性痴...     

组胺对人肝星状细胞合成Ⅰ型胶原的影响

研究组胺对人肝星状细胞(HSC-T6)合成Ⅰ型胶原的影响,探讨肥大细胞(MC)在慢性肝疾病中的作用机理。采用不同浓度(5×10-6、10×10-6、50×10-6、100×10-6mol/L)组胺刺激体外培养的HSC-T6;并设立不同时间点(24、36、48h)分别收集培养上清液,ELISA法测定培养上清液中的Ⅰ型胶原含量。结果表明,组胺能明显促进HSC合成分泌Ⅰ型胶原,且存在一定的时效关系和量效关系,MC可以通过其分泌的生物活性介质(组胺)增强HSC-T6分泌Ⅰ型胶原,而参与慢性肝病发生发展过程。     

产妇“死”而复生，医生为何见死不救

因误信电视上天花乱坠的广告宣传,临盆产妇裴传琴住进了安徽含山县天城医院。在剖腹产手术中,裴传琴因子宫大出血生命告急,医院没有备足血浆,家属几次要求转院,都被医院拒绝。医生没有征得病人家属同意,将裴传琴子宫切除,宣布她因抢救无效死亡。可一个小时后,裴传琴却突然发出了“快救救我,我疼”的呼救声,见妻子没有死,唐泽志立即跑去找医生来救妻子。     

一例胸椎肿瘤全椎体切除的手术配合

目的：探讨肿瘤全椎体切除植骨椎弓根钉内固定手术配合体会。方法：加强术前访视、术中护理配合,积极采取针对性的护理措施,预防术中并发症的发生。结果手术配合默契,术后病情好转,出院3个月随访,患者功能恢复良好,未出现并发症和不良反应。结论：术前完善的准备、术中紧密的医护配合及术后并发症的观察是手术成功的重要保证。