COVID-19, digital privacy,and the social limits on data-focused public health responses

The implementation of digital contact tracing applications around the world to help reduce the spread of the COVID-19 pandemic represents one of the most ambitious uses of massive-scale citizen data ever attempted. There is major divergence among nations, however, between a “privacy-first” approach which protects citizens’ data at the cost of extremely limited access for public health authorities and researchers, and a “data-first” approach which stores large amounts of data which, while of immeasurable value to epidemiologists and other researchers, may significantly intrude upon citizens’ privacy. The lack of a consensus on privacy protection in the contact tracing process creates risks of non-compliance or deliberate obfuscation from citizens who fear revealing private aspects of their lives – a factor greatly exacerbated by recent major scandals over online privacy and the illicit use of citizens’ digital information, which have heightened public consciousness of these issues and created significant new challenges for any collection of large-scale public data. While digital contact tracing for COVID-19 remains in its infancy, the lack of consensus around best practices for its implementation and for reassuring citizens of the protection of their privacy may already have impeded its capacity to contribute to the pandemic response.     

Locked-down digital work

Covid-19 and the related lockdown in many countries made digital work no longer just an option, but the new norm for many office workers who began to make sense of a new range of benefits of digital work tools. Based on my own observations and on observations shared by executives in New Zealand and Europe, I illustrate in this article how the lockdown acted as a facilitator for digital work. Further, I show how the lockdown gave many individuals a flawed impression of digital work, i.e. their experience occurred during exceptional circumstances and led them to draw false conclusions about digital work. I examine some misconceptions of locked-down digital work and discuss the implications of locked-down digital work for research and practice.     

自然法理论在18—19世纪的失落

自然法理论在18—19世纪的失落主要体现在三个方面：一是卢梭、黑格尔、休谟和边沁等人对自然法推理论证体系的否定;二是奥斯丁和萨维尼等人对自然法法律理论的否定;三是休谟和孔德等人对自然法理性哲学观的否定。在近代思想家批判自然法理论的过程中,不仅在近代资产阶级革命中发挥了巨大影响的自然法政治理论几乎被全盘否定,甚至连自然法观念本身也被一起抛弃了。     

CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement

Since it was first recognized in bacteria and archaea as a mechanism for innate viral immunity in the early 2010 s,clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas) has rapidly been developed into a robust, multifunctional genome editing tool with many uses. Following the discovery of the initial CRISPR/Cas-based system, the technology has been advanced to facilitate a multitude of different functions. These include development as a base editor, prime editor, epigenetic editor, and CRISPR interference(CRISPRi) and CRISPR activator(CRISPRa) gene regulators. It can also be used for chromatin and RNA targeting and imaging. Its applications have proved revolutionary across numerous biological fields, especially in biomedical and agricultural improvement. As a diagnostic tool, CRISPR has been developed to aid the detection and screening of both human and plant diseases, and has even been applied during the current coronavirus disease 2019(COVID-19) pandemic. CRISPR/Cas is also being trialed as a new form of gene therapy for treating various human diseases, including cancers, and has aided drug development. In terms of agricultural breeding, precise targeting of biological pathways via CRISPR/Cas has been key to regulating molecular biosynthesis and allowing modification of proteins, starch, oil, and other functional components for crop improvement. Adding to this, CRISPR/Cas has been shown capable of significantly enhancing both plant tolerance to environmental stresses and overall crop yield via the targeting of various agronomically important gene regulators. Looking to the future, increasing the efficiency and precision of CRISPR/Cas delivery systems and limiting off-target activity are two major challenges for wider application of the technology. This review provides an in-depth overview of current CRISPR development, including the advantages and disadvantages of the technology,recent applications, and future considerations.     

Is remote near-peer anatomy teaching an effective teaching strategy? Lessons learned from the transition to online learning during the Covid-19 pandemic

In response to the Covid-19 pandemic, medical educators have transformed pre-clerkship anatomy curricula into online formats. The purpose of this study was to evaluate the effectiveness and student perceptions of an online near-peer anatomy curriculum. The classes of 2022 and 2023 completed identical foundational anatomy curricula in-person, whereas the class of 2024 completed an adapted curriculum for remote online learning. Quantitative and qualitative responses were used to compare attitudes between instructional methods. Assessment scores and evaluation survey responses were collected from the classes of 2022 (n = 185), 2023 (n = 184), and 2024 (n = 183). Mean assessment scores (±SD) for the classes of 2022, 2023, and 2024 were 93.64% (±5.86), 93.75% (±4.09), and 92.04% (±4.83), respectively. Post hoc group comparisons showed the class of 2024 scored significantly lower than the two previous classes [2022: (H(1) = 18.58, P < 0.001), 2023: (H(1) = 18.65, P < 0.001)]. Mean survey results concerning curriculum quality were 4.06/5.00 for the class of 2023 and 3.57/5.0 for the class of 2024 (t(365) = 2.67, P = 0.008). Considering a small effect size (η² = 0.034), there was no meaningful difference in student assessment scores. A potential drawback of online near-peer anatomy teaching remains in student perceptions of course quality; qualitative feedback suggested technological limitations and perceptions of online course instructors were partly responsible for lower student satisfaction. Following the Covid-19 pandemic, medical educators should incorporate the lessons learned from this unique educational inflection point to improve curricula moving forward.     

14-19岁青少年教育:21世纪初英国教育战略分析

英国21世纪青少年教育战略强调全员受教与个性化发展相结合,提高综合素质与关键能力,发展职业教育.在"卓越"与"共生"意识的指导下,该战略包含许多切实有效的措施,但同时也存在着一些问题.本文通过分析该战略,以期对我国基础教育政策的制订有所启示.     

Teaching first‐year statistics students with COVID‐19 real‐world data: Graphs

It is said that a picture is worth a thousand words, but what about graphs? Although graphs have the potential to bring data to life, numerous studies show that learners struggle with graphical comprehension. Furthermore, many textbook examples on graphs are boring and appear meaningless to students. Students want to know more about something which is interesting, meaningful, and worth knowing, in other words, something relevant. With the outbreak of the novel coronavirus in December 2019, COVID‐19 is dominating the news worldwide, and the internet is flooded with visual presentations about the virus. To make statistics more fascinating and exciting, relevant and real‐world data such as these can be used in the classroom to stimulate the learning of important statistical concepts such as graphs. Curcio's three levels of graphical comprehension were used as a framework in this study, while the importance of developing a global view on distributions was also emphasized.     

Intersecting barriers to adolescents’ educational access during COVID-19: Exploring the role of gender,disability and poverty

This article explores the social determinants of adolescents’ access to education during the COVID-19 pandemic in three diverse urban contexts in Bangladesh, Ethiopia and Jordan. It provides novel empirical data from the Gender and Adolescence: Global Evidence longitudinal study, drawing on phone surveys (4441), qualitative interviews with adolescents aged 12–19 years (500), and key informant interviews conducted between April and October 2020. Findings highlight that the pandemic is compounding pre-existing vulnerabilities to educational disadvantage, and that gender, poverty and disability are intersecting to deepen social inequalities. The paper concludes by reflecting on policy implications for inclusive distance education in emergencies.