Being Open without Talking about It: A Rhetorical/Normative Approach to Understanding Topic Avoidance in Families after a Lung Cancer Diagnosis

The present study uses a rhetorical/normative perspective to examine families' communication and coping in response to a parent's diagnosis of, and eventual death from, lung cancer. Through in-depth, semistructured interviews with 35 adult children, we identified two broad areas of communicative avoidance (avoiding information and avoiding emotion) and three general ways of managing avoidance and openness (denial, segmentation, and being open while avoiding). The interviews suggested that denial was a particularly dissatisfying means of managing competing goals, whereas being open while avoiding appeared to be functional for family members. The discussion focuses on our understanding of reasons why people avoid in this context, implications for rhetorical/normative approaches and theories of information management, and practical implications of the current findings.     

A Multiple Goals Perspective on Topic Avoidance and Relationship Satisfaction in the Context of Breast Cancer

Using a multiple goals perspective on interpersonal communication as a theoretical framework, this study examined the circumstances under which topic avoidance might predict lower relationship satisfaction among women coping with breast cancer. Results gathered from questionnaire responses of women who had recently undergone treatment for breast cancer (N=140) indicated that the association between topic avoidance and relationship satisfaction was moderated by patients' own reasons for avoidance, and by perceptions of partners' reasons for avoidance. The findings of this study contribute to recent scholarship suggesting the importance of considering the motivations for and interpretations of topic avoidance in order to better understand how patterns of topic avoidance predict relational wellbeing.     

Mapping the Health Communication Infrastructure in Rural Senegal: an Assessment to Support Cervical Cancer Screening

Cervical cancer is the leading cause of women's cancer deaths in Senegal, but few medical personnel are trained to perform cervical cancer screening. In rural areas, the situation is worse. To remedy this, a collaborative of researchers and stakeholders trained local health-care workers in cervical cancer screening through the “training-of-trainers” method. However, lack of cancer screening knowledge, barriers, and a hard-to-reach population may jeopardize the collaborative's efforts. The purpose of this study is to map the health communication infrastructure by applying communication infrastructure theory to assess general health and cancer screening knowledge, as well as attitudes and barriers toward screening. Results from focus groups and interviews show that women have minimal knowledge of cervical cancer. Moreover, health workers report detrimental attitudes in menopausal women. Our findings identified routes for information dissemination and attitude change including community radio and local health talks.     

Review：Proteomic technology for biomarker profiling in cancer： an update

CANCER BIOMARKERS: CURRENT STATUS Despite advances in diagnostic imaging technol-ogy, surgical management, and therapeutic modalities,cancer remains a major cause of mortality worldwide.Currently, it is estimated that cancer kills over 6 mill-ion people per year worldwide, with over 10 millionnew cases being diagnosed every year. Mortality ismainly attributed to dissemination of primary cancerto distant organs, on which no effective treatment isavailable. The dilemma in oncology p…     

Information requirements of cancer center researchers focusing on human biological samples and associated data

This study was undertaken to characterize the information requirements of cancer researchers who were specifically interested in human biological specimens at a comprehensive cancer center, and to determine if existing information systems could meet those needs. Information required by the cancer center researchers at the University of Pittsburgh Cancer Institute (UPCI, Pittsburgh, PA) was identified through interviews, query analysis, and analysis of publications. For topical matters, the study found that the most frequent types of questions were the following: clinical (50.18%), prognosis (17.87%), diagnosis/disorder-based (50.72%), and research-oriented (51.9%) queries. In terms of the required data elements, pathology data (17.32%) was the most frequently required, followed by clinical history and outcomes (15.18%). In addition, the study identified the 10 main questions, concerning human biological samples, and the majority of the questions were represented in a fairly discrete set of information spaces that could be well mapped into the conceptual data model created through the study. The results found in this study can be used for an initial data modeling, when creating a biomedical research data warehouse that would support the majority of the transitional research requirements of the UPCI.     

Mothers,Sons and Testicular Cancer: An Exploratory Investigation of Health Communication

This study highlights the importance of parent-child communication of sensitive health-related issues, specifically the importance of cancer prevention discussions. For females, communication about breast cancer has been desensitized; yet, testicular cancer is not being discussed among males, even though it is highly curable when caught early. Testicular cancer primarily impacts males ages 15–40, so introducing the conversation early is important. In this exploratory study, mothers (N = 22) participated in three focus group discussions and described communication with their sons about general health issues and testicular cancer. While the mothers discussed a number of health issues with their sons, they did not mention testicular cancer and believed their sons knew very little about testicular cancer. Mothers' communication about testicular cancer with their sons was characterized by uncertainty and ambiguity. Findings from this study shed light on how little mothers know about testicular cancer as well as the need for comprehensive testicular cancer campaigns that target intervening publics.     

Glycoprotein components in the serum of patients with cancer breast

The levels of total sialic acid, lipid bound sialic acid and fucose were estimated in the sera of patients with benign and malignant tumours of breast. An increase was noted in all the three parameters, with a more marked increase in malignancy, when compared with benign and controls. Consequent to surgery, there was an elevation in the serum levels of the above parameters than the values prior to surgery and a decline was noted two months after surgery although none of the values reached the normal range. These results suggest a close association of the glycoproteins with the tumour burden and further signify their role in early detection and staging of cancer breast.     

Colorectal cancer screening and adverse childhood experiences: Which adversities matter?

Adverse Childhood Experiences (ACEs) have been associated with an increased risk of a variety of diseases, including cancer. However, research has not paid enough attention to the association between ACEs and cancer screening. As such, the present study examined the association between ACEs and ever using colorectal cancer (CRC) screening, among adults age 50 and over. Analyses used the 2011 Behavioral Risk Factor Surveillance System (n = 24,938) to model odds of ever engaging in CRC screening from nine different adversities. Bivariate and multivariate models were fit. In bivariate models, physical abuse, having parents that were divorced or separated, and living in a household where adults treated each other violently were associated with lower odds of engaging in CRC. In multivariate models that accounted for potential confounders, emotional and sexual abuse were each associated with higher odds of engaging in CRC. Results suggest potential pathways by which early childhood experiences can impact future health behaviors. Future research should examine this association longitudinally.     

Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications

Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells seriously limit the efficacy of various anticancer drugs. Autophagy, a self-degradative system that maintains cellular homeostasis, universally operates under normal and stress conditions in cancer cells. The roles of autophagy in cancer treatment are still controversial because both stimulation and inhibition of autophagy have been reported to enhance the effects of anticancer drugs. Thus, the important question arises as to whether we should try to strengthen or suppress autophagy during cancer therapy. Currently, autophagy can be divided into four main forms according to its different functions during cancer treatment: cytoprotective (cell survival), cytotoxic (cell death), cytostatic (growth arrest), and nonprotective (no contribution to cell death or survival). In addition, various cell death modes, such as apoptosis, necrosis, ferroptosis, senescence, and mitotic catastrophe, all contribute to the anticancer effects of drugs. The interaction between autophagy and these cell death modes is complex and can lead to anticancer drugs having different or even completely opposite effects on treatment. Therefore, it is important to understand the underlying contexts in which autophagy inhibition or activation will be beneficial or detrimental. That is, appropriate therapeutic strategies should be adopted in light of the different functions of autophagy. This review provides an overview of recent insights into the evolving relationship between autophagy and cancer treatment.     

Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects

Translationally controlled tumor protein (TCTP) is a highly conserved multifunctional protein localized in the cytoplasm and nucleus of eukaryotic cells. It is secreted through exosomes and its degradation is associated with the ubiquitin-proteasome system (UPS), heat shock protein 27 (Hsp27), and chaperone-mediated autophagy (CMA). Its structure contains three α‍-helices and eleven β‍-strands, and features a helical hairpin as its hallmark. TCTP shows a remarkable similarity to the methionine-R-sulfoxide reductase B (MsrB) and mammalian suppressor of Sec4 (Mss4/Dss4) protein families, which exerts guanine nucleotide exchange factor (GEF) activity on small guanosine triphosphatase (GTPase) proteins, suggesting that some functions of TCTP may at least depend on its GEF action. Indeed, TCTP exerts GEF activity on Ras homolog enriched in brain (Rheb) to boost the growth and proliferation of Drosophila cells. TCTP also enhances the expression of cell division control protein 42 homolog (Cdc42) to promote cancer cell invasion and migration. Moreover, TCTP regulates cytoskeleton organization by interacting with actin microfilament (MF) and microtubule (MT) proteins and inducing the epithelial-mesenchymal transition (EMT) process. In essence, TCTP promotes cancer cell movement. It is usually highly expressed in cancerous tissues and thus reduces patient survival; meanwhile, drugs can target TCTP to reduce this effect. In this review, we summarize the mechanisms of TCTP in promoting cancer invasion and migration, and describe the current inhibitory strategy to target TCTP in cancerous diseases.