Naming and Claiming Cancer among African American Women: An Application of Problematic Integration Theory

This study examines how a sample of African American women understands the uncertainties fundamental to cancer risk communication. Utilizing data from four focus groups, Problematic Integration (PI) theory is applied as an interpretive lens for illustrating their felt difficulties of talking openly about cancer and breast cancer in everyday life. The women describe worry about cancer and its prevalence among African American women; ambivalence and uncertainty; belief that what is not uncertain is certain and awful; fear and avoidance; contradictions in “claiming” and “rebuking” cancer; and hopefulness.     

Communication anxiety and signing effectiveness: Testing an interference model among deaf communicators

Couples coping with cancer are often told to talk about feelings, yet there is limited theoretical, empirical, or intervention research to justify this advice. We interviewed 19 patients and 16 partners about their communication. In a mixed methods analysis, we found talk about feelings was associated with distress and functioning, even after controlling for marital satisfaction, perceived constraint from discussing cancer, or physical functioning; however, patients and partners who focused on feelings and personal issues had worse outcomes than those who focused on facts and medical issues. Through qualitative analysis, we found multiple ways to cope that did not require talking about feelings as well as ways that higher levels of distress affected talk about feelings. Our findings suggest we should reconsider advice to couples, encouraging multiple ways of communicating, and considering contextual factors that influence the timing and desirability of talk about feelings.     

P53基因蛋白在消化道肿瘤中的表达同浸润深度与转移的相关性观察

目的探讨P53基因表达与胃癌、肠癌、食管癌的相互关系.方法采用SP免疫组化染色方法.检测了消化道癌中(胃癌22例、肠癌22例、食管癌60例)P53蛋白的表达率.结果P53蛋白在胃癌中表达率最高达63.6%,肠癌中表达率为55.0%,食管癌中的表达率为61.7%.结论P53蛋白在消化道肿瘤中普遍表达并且当癌浸润较深和有淋巴结转移者阳性率较高.     

表观遗传修饰和代谢重编程对乳腺癌干细胞的调控

概乳腺癌已居我国女性恶性肿瘤死亡率首位。近来研究表明,乳腺肿瘤组织内有少量具有自我更新和分化潜能的肿瘤干细胞,这些肿瘤干细胞在乳腺癌发生、发展、转移及复发过程中起关键作用。深入研究乳腺癌干细胞的调控机制对乳腺癌的预防和治疗具有十分重要意义。本文综合近期的研究成果,概括了表观遗传修饰和代谢重编程对上皮间质转化及乳腺癌干细胞的调控机制,且系统地分析与总结了表观遗传修饰、代谢重编程、上皮间质转化和乳腺癌干细胞之间的相互关系。     

Stability of total and free prostate specific antigen in serum samples at different storage conditions

The present preliminary study was performed to find out stability of total prostate specific antigen (PSA) and free prostate specific antigen (FPSA) in serum of healthy males as well as in patients of benign and malignant disorders of prostate at various freezing and nonfreezing temperatures and at different duration of time. The results of our study indicated long-term stability of both the analytes in frozen serum. Serum total and free PSA were stable only for three to four days in regular refrigerators in unfrozen states. Clotted blood kept at room temperature (25°C–30°C) did not cause change in concentrations of both the analytes for twenty four hours.     

A study of serum zinc, selenium and copper levels in carcinoma of esophagus patients

The association of serum trace elements like selenium, zinc and copper has been found in different types of cancer. This study was conducted to see the serum level of these three trace elements in cancer esophagus patients. Biopsy confirmed cancer esophagus, 24 patients (12 males, 12 females, mean age 54.5±11.65 year with 23 healthy subjects (16 males, 7 females, mean age 44 ±13.82 years) were included in this study. Both control and study group patients were of same socio-economic status and dietary habits. Serum zinc and copper level were estimated using standard absorption spectrometer technique and serum selenium by Hydride generation method. We observed significant low serum levels of zinc and selenium while high level of serum copper in carcinoma esophagus patients, as compared with normal healthy controls. This shows an association of serum selenium zinc and copper with cancer esophagus.     

单克隆抗体在肿瘤治疗中的应用

随着一些单克隆抗体获准被应用于临床,单抗在肿瘤治疗中的运用得到了快速发展。其中代表性的有抗血管内皮生长因子的单抗bevacizumab(Avastin),和抗表皮生长因子的cetuximab(Erbitux)。结合常规的化疗,bevacizumab能够显著延长结肠癌、乳腺癌及肺癌患者的生命。Cetuximab无论与化疗联合使用或单独使用对于对化疗有耐药性的结肠癌直肠癌均有显著的临床意义。     

乳腺癌106例临床病理分析

目的 :探讨张家口地区乳腺癌的发病规律。方法 :对我科 2 0 0 1～ 2 0 0 2年收集的 10 6例乳腺癌进行回顾性分析。结果 :36～ 5 5岁者占 70 %以上 ,2 6岁以下和 6 6岁以上患者极少 ;浸润性导管占 75 .4 7% ,淋巴结总转移率为 4 0 .6 %。结论 :乳腺肿物早就诊对乳腺癌的早期诊断与预后有重要的意义。