E-cadherin在涎腺粘液表皮样癌的表达及其与浸润转移的关系

目的:细胞粘附功能下降是恶性肿瘤发展的关键因素,为探讨E-cadherin在涎腺粘液表皮样癌发病机制中的作用,我们研究了E-cadherin在涎腺粘液表皮样癌的表达情况,并分析其与临床病理特征的关系。方法:采用免疫组织化学S-P法对46例涎腺粘液表皮样癌进行E-cadherin的检测。结果:E-cadherin在涎腺粘液表皮样癌中的表达强弱与癌组织的分化程度及淋巴结转移有关(P<0.05),而与患者的性别、年龄无关(P>0.05)。结论:E-cadherin表达与涎腺粘液表皮样癌的浸润转移有关,可作为一种新的肿瘤标志物,其表达对判断预后有一定的价值。     

BRCA1/2 associated hereditary breast cancer

Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes,focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial;further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.     

GST-π在乳腺癌中的表达及意义

目的:探讨GST-π在乳腺癌中的表达及意义.方法:采用免疫组化的方法对GST-π在47例乳腺癌中的表达及临床意义进行研究.结果:GST-π总的阳性率为61.70%(29/47),在浸润性导管癌、单纯癌、髓样癌中的阳性率分别为62.06%、83.33%、50.00%.GST-π在乳腺癌中的表达与年龄、病理学类型及淋巴结转移无明显相关性.结论:GST-π在乳腺癌中的表达率较高,且与耐药有关,应重视对乳腺癌中GST-π表达的检测,以便优化化疗方案.     

乳腺癌组织中c-erbB-2、p53和nm23蛋白表达及相互关系和意义

目的　探讨c erbB 2、p53和nm2 3蛋白在乳腺癌组织中的表达与乳腺癌临床病理参数、雌激素受体 (ER)、孕激素受体 (PR)的关系。方法　应用免疫组化ABC法对 5 5例乳腺癌组织中的c erbB 2、p53和nm2 3蛋白表达进行检测。结果　 5 5例乳腺癌中c erbB 2、p53及nm2 3的阳性率分别为 49 1 % (2 7/5 5 )、47 3 % (2 6 /5 5 )和 49 1 % (2 7/5 5 ) ,c erbB 2和p53蛋白在乳腺癌中的阳性率与肿瘤病理分级及淋巴结转移有显著意义 (P <0 0 5 ) ,与雌孕激素受体状况呈负相关 (P <0 0 1 )。nm2 3蛋白在乳腺癌中的阳性率与肿瘤病理分级、淋巴结转移有密切的关系 (p <0 0 5 ) ,与雌孕激素受体状呈正相关 (p <0 0 1 )。 70 9% (3 9/5 5 )肿瘤有上述蛋白的异常表达 ,其中 49 1 % (2 7/5 5 )的肿瘤同时有多个蛋白异常表达。结论　肿瘤的多因素分析比单因素分析更有价值 ,癌基因c erbB 2、nm2 3和抑癌基因p53蛋白的表达异常及协同作用在乳腺癌的发生发展中起重要使用     

405例乳腺疾病术中冰冻切片病理诊断分析

调查了上海市奉贤区中心医院乳腺疾病的术中冰冻切片的正确性、及时性情况，分析影响其正确性、及时性的原因，为乳腺疾病术中冰冻切片的质量提供科学依据；将开展冰冻切片以来的所有乳腺疾病405例进行分析，探求延迟报告及误诊原因，96．79％左右的乳腺疾病术中冰冻切片病理诊断可以正确、及时发出报告。     

淋巴血管在肿瘤转移和免疫生物学中的作用（英文）

淋巴系统被认为是肿瘤转移的重要途径之一,所以通常情况下肿瘤引起的淋巴血管增生会降低肿瘤预后,治疗上也建议淋巴清扫。但是最新的研究显示,淋巴系统可能对肿瘤免疫治疗有促进作用。这篇综述的主要目的是对相关领域做一个简短总结,以期待将来有更多的研究来关注淋巴系统对肿瘤治疗的影响。文章首先介绍肿瘤淋巴血管增生和淋巴转移的分子机制,然后介绍淋巴系统在肿瘤免疫中的作用,最后利用最新研究来证明淋巴系统有增强肿瘤免疫治疗的作用。     

Vascular architecture:is it a helpful histopathological biomarker for hepatocellular carcinoma?

Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the world.Although originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of different liver in-flammatory,fibrotic,and ischemic conditions.Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue,and discuss why this parameter might provide additional information regarding cancer behavior.The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation,and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process.     

有氧运动对癌症患者康复作用的研究现状

在文献资料研究的基础上,从生理心理等角度综述了有氧运动对癌症患者康复的作用,阐述了有氧运动对于防止癌症发生,抑制肿瘤细胞生长有积极作用,并能帮助癌症患者减少癌症不适症状和并发症,维持和提高生理功能,改善体脂、体重指数和机能代谢,增强机体免疫功能,从而使癌症患者改善心理状态,恢复职业和社交活动能力,提高生存机率和生活质量。结果提示有氧运动可以成功地帮助众多不同阶段和不同性质种类的癌症患者进行安全有效的康复治疗。     

Induced pluripotent stem cell-related genes influence biological behavior and 5-fluorouracil sensitivity of colorectal cancer cells

Objective  

We aimed to perform a preliminary study of the association between induced pluripotent stem cell (iPS)-related genes and biological behavior of human colorectal cancer (CRC) cells, and the potential for developing anti-cancer drugs targeting these genes.     

Being Open without Talking about It: A Rhetorical/Normative Approach to Understanding Topic Avoidance in Families after a Lung Cancer Diagnosis

The present study uses a rhetorical/normative perspective to examine families' communication and coping in response to a parent's diagnosis of, and eventual death from, lung cancer. Through in-depth, semistructured interviews with 35 adult children, we identified two broad areas of communicative avoidance (avoiding information and avoiding emotion) and three general ways of managing avoidance and openness (denial, segmentation, and being open while avoiding). The interviews suggested that denial was a particularly dissatisfying means of managing competing goals, whereas being open while avoiding appeared to be functional for family members. The discussion focuses on our understanding of reasons why people avoid in this context, implications for rhetorical/normative approaches and theories of information management, and practical implications of the current findings.