Evaluation of Oxidative Stress and hsCRP in Polycystic Ovarian Syndrome in a Tertiary Care Hospital

PCOS is a heterogeneous endocrine disorder with diverse clinical presentation. Oxidative stress plays a key role in the pathophysiology of this disease. Serumhigh sensitive C-reactive protein (hsCRP), a marker of chronic low grade inflammation, is indicative of future development of cardiovascular disease. Our aim is to evaluate the oxidant status and hsCRP levels in PCOS. The study involved 61 cases and 61 controls in the age group of 18–40 years diagnosed with PCOS. Erythrocyte malondialdehyde (MDA), superoxide dismutase (SOD), serum hsCRP, gonadotrophins, thyroid stimulating hormone, prolactin, glycemic status and lipid profile were estimated. Erythrocyte MDA (p < 0.001), SOD (p = 0.007) and serum hsCRP (p < 0.001) were significantly elevated in PCOS patients than controls. Oxidative stress is present in women with PCOS along with elevated hsCRP.     

导致古代木质沉船腐蚀的生物类群及其腐蚀历程

海洋出水木质文物和陆地考古发掘出土木质文物相比,生物类病害表现得特别明显。借鉴海洋工程学和“南海I号”相关研究成果,我们将导致古代木质沉船腐蚀的生物分为三大类:海洋植物、海洋动物和海洋微生物。船体的腐蚀过程主要分为三个阶段:固相表面形成生物膜阶段;大型污损生物等的幼体附着于前期形成的生物膜之上阶段;群落趋于稳定、船体木质逐步降解阶段。沉船腐蚀过程中不同生物类群之间共生或寄生在一起形成动态平衡,因此,对于出水木质文物的生物修复应该在保证生物群落稳定的状态下进行,避免单一种群剧烈发展对文物造成的二次损害。     

浅析高校突发事件的应急处置——以急病事件为例

大学生突发事件严重威胁到大学生生命财产安全,是影响高校安全稳定的重大因素。本文通过分析大学生面对急病事件时的无助与措手不及的原因,结合探索和实践给出具体的处置指引,帮助学生在面对突发事件如何及时有效的应对,把握好救人的黄金时间点,挽救生命。     

有氧健美操对女大学生心血管功能的影响

研究目的：研究有氧健美操对女大学生心血管功能的影响。研究方法：将参加一学年健美操训练的女大学生作为试验组，未系统参加健美探训练的女大学生作为对照组，进行安静时和运动负荷达125w时的心率、每博输出量、心输出量，以及测定运动训练中，心率达到170次／min时的稳定状况下做的功率(PWCl70)值进行比较。结果表明试验组无论在安静状态下，还是运动负荷达到125w时的心率都比对照组缓慢。在运动负荷达125w时每博输出量试验组明显高于对照组，结论：实验组女大学生心脏泵血功能通过健美操训练获得明显提高。     

对高校教职工血脂水平的调查分析

对高校8100例教职工血脂水平进行了调查分析,血脂(CHOL和TG)参考值测定结果与原参考值相比水平有所提高,CHOL超过均值上限和低于下限的比例基本相同,约15%,而TG超过的均值上限的比例(9 8%)明显高于下限的比例(0 03%),各年龄组间TG和CHOL水平存在显著性差异(P<0.01及0.05)。     

浅析健身气功防病治病机理与作用

健身气功通过调心、调身、调息,在心理上调节改善人的不良心理状态,在生理上可疏通经络,保证人体气血畅通。通过特定的形体运动、呼吸,以心为主导的整体养生具有保精、养气、存神的作用。由于精、气、神存在,健身气功可以平衡阴阳、调和气血、疏通经络,从而达到扶正祛邪、防病治病的作用。     

体育舞蹈训练对心血管系统影响的实验研究

以先进的临床实验技术，应用彩色B—型超声方法，通过对38名健康女性，分为正常人组、经常锻炼组与业余训练组的心血管系统变化进行分析比较，发现体育舞蹈训练可以增强心血管系统的功能，心血管系统的变化接近于耐力项目，正常人组、经常锻炼组与业余训练组的实验结果出现了非常明显差别。     

Myeloperoxidase in Chronic Kidney Disease

Numerous lines of evidence implicate a role of myeloperoxidase (MPO) in the pathogenesis of cardiovascular disease (CVD). It is a well accepted fact that patients with chronic kidney disease (CKD) are at an increased risk for CVD. MPO is a pro-oxidant enzyme which could be involved in the increased susceptibility of these patients to CVD. Hence, the levels of plasma MPO was determined in healthy controls as well as in patients with CKD [stratified with the level of their kidney failure as CKD stages II–V (end stage renal disease)]. Plasma MPO was assayed by a spectrophotometric method. Serum urea and creatinine were estimated on a clinical chemistry analyzer using standard laboratory procedures. The mean plasma MPO levels were significantly lower with advancing stages of renal failure (P < 0.001). There was a positive correlation between MPO and GFR (r = +0.89, P < 0.001) and a negative correlation with urea (r = −0.85, P < 0.001) and creatinine (r = −0.82, P < 0.001). While an inverse association was observed between plasma MPO and urea in CKD patients, such an association was not observed in control subjects (P = 0.43). In conclusion, the decline in plasma MPO levels may be due to the inhibitory effect of uraemic toxins on the enzyme.     

Using clinical guidelines to assess the potential value of laboratory medicine in clinical decision-making

IntroductionIt is often quoted that 70% of clinical decisions are based on laboratory results, but the evidence to substantiate this claim is lacking. Since clinical guidelines aim to document best-practice decision making for specific disease conditions, inclusion of any laboratory test means that the best available evidence is recommending clinicians use it. Cardiovascular disease (CVD) is the world’s most common cause of mortality, so this study reviewed all CVD guidelines published by five national/international authorities to determine what proportion of them recommended laboratory testing.Materials and methodsFive leading CVD guidelines were examined, namely the European Society of Cardiology (ESC), the UK National Institute for Health and Clinical Excellence (NICE), the American College of Cardiology (ACC), the Australian Heart Foundation (AHF) and the Cardiac Society of Australia and New Zealand (CSANZ).ResultsA total of 101 guidelines were reviewed. Of the 33 individual ESC guidelines relating to CVD, 24/33 made a direct reference to the use of clinical laboratory tests in either diagnosis or follow-up treatment. The same applied to 15/20 of NICE guidelines, 24/32 from the ACC and 15/16 from the AHF/CSANZ. Renal function and blood count testing were the most recommended (39 and 26 times), with lipid, troponin and natriuretic peptide measurement advocated 25, 19 and 19 times respectively.ConclusionsThis study has shown that laboratory testing is advocated by between 73% and 94% of individual CVD guideline recommendations from five national/international authorities. This provides an index to assess the potential value of laboratory medicine to healthcare.     

健身运动处方锻炼对男大学生心泵功能与血压的影响

影响体质与健康的重要因素之一是心血管功能。纵观全国三次大规模的大学生体质测试结果,都显示大学生心功能有下降的趋势。因此,如何有针对性的通过体育锻炼提高大学生心血管功能,是我们应该重视并尽快解决的问题。本研究研制不同性质的健身运动处方,指导男大学生进行课外体育锻炼,观察不同性质健身运动处方锻炼对心血管功能的影响。结果表明:本研究制定的速度、耐力、篮球、足球、排球与全面锻炼6套健身运动处方对增强男大学生的心泵血功能有较强的作用,力量、耐力、健美操及排球运动处方对改善血管功能有较好的效果。