405例乳腺疾病术中冰冻切片病理诊断分析

调查了上海市奉贤区中心医院乳腺疾病的术中冰冻切片的正确性、及时性情况，分析影响其正确性、及时性的原因，为乳腺疾病术中冰冻切片的质量提供科学依据；将开展冰冻切片以来的所有乳腺疾病405例进行分析，探求延迟报告及误诊原因，96．79％左右的乳腺疾病术中冰冻切片病理诊断可以正确、及时发出报告。     

果树病虫害防治的几个关键时期

笔者根据多年经验对果树病虫害主要种类及发生趋势、病虫害的防治等几个关键时期作一简要介绍。     

Separation and identification of thyroid autoantibodies in patients with thyroid disorders by hydrophobic column

A method has been developed to separate and identify thyroglobulin autoantibody (TgAb) and thyroid peroxidase autoantibody (TPOAb) in serum obtained from normal and autoimmune thyroid diseases using phenyl Sepharose CL-4B hydrophobic column. The protein peaks obtained from hydrophobic column were identified as TgAb and TPOAb by comparing the elution profile of commercially purified standard thyroid autoantibodies. The similarity of the inhibitory effects of eluted proteins and of standard thyroid autoantibodies on lectin concanavalin A-RBC interaction confirmed the separation of TPO-Ab and TgAb by the hydrophobic, column. The eluted fractions from the hydrophobic column were estimated by the radio immunoassay (RIA) to confirm the presence of both auto-antibodies. This hydrophobic column method offers an advantage of visual inspection of this autoantibodies by graphic representation of peak height along with their estimation in autoimmune thyroid disorders.     

长链非编码RNA（1ncRNAs）的研究策略及其在中枢神经退行性疾病中的研究进展

长链非编码RNA（IncRNAs）是真核细胞中转录本长度超过200nt的非编码RNA。近年来的研究表明lncRNAs具有一系列的重要功能,包括影响转录、RNA剪切、翻译、核因子转运、基因重排及染色质修饰等,lncRNAs的异常表达常与肿瘤、神经退行性疾病、心血管系统疾病等的发生发展密切相关,因此对lncRNAs的研究将有助于对机体生理病理反应的内在机制形成更为系统的认识。该文就lncRNAs的研究策略及其在神经退行性疾病中的研究进展进行了综述,以期为神经系统调控网络的建立及神经退行性疾病的防治提供新的思路。     

药用植物金银花病虫害种类及综合防治

金银花是重要的药用植物,在中医临床上应用具有悠久的历史.本文就金银花病虫害的种类、危害特点及其防治技术进行了研究和总结,旨在为人工种植金银花的病虫害防治提供参考.     

大学生门诊常见疾病的预防及健康教育

文章结合大学生门诊常见疾病的预防措施,强调在高校中开展健康教育的意义,通过普及卫生保健知识,促进大学生自愿地采用健康行为,指导自己正确的生活方式,从而提高大学生身心健康水平。     

中国早期对疾病的认识与治疗

先秦时期是中国医学的萌芽阶段,这一阶段,中华先民已经对呼吸系统、消化系统等内科疾病,痈疽、痤疽、痔疾、踝厥及外伤性疾病,妇科、儿科、五官科、传染性疾病的病理等已有了较为科学的认识,巫术治疗、药物治疗及技术治疗等对疾病控制的手段,从一个侧面反映了先秦时期医学的发展历程和成就.     

Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood

Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. The aim of this study is to assess associations of various types of psychosocial adversity and cumulative adversity in childhood, with multiple CVD risk factors in mid-life. At study enrolment, women from the Avon Longitudinal Study of Parents and Children (N = 3612) retrospectively reported: lack of maternal care, maternal overprotection, parental mental illness, household dysfunction, sexual abuse, physical and emotional abuse, and neglect in childhood. Approximately 23 years later, body mass index (BMI), waist circumference, systolic and diastolic blood pressure, plasma glucose, insulin, triglycerides, low and high density lipoprotein cholesterol, C-reactive protein, carotid intima-media thickness (cIMT) and arterial distensibility were assessed (mean age 51 years). We examined associations of each specific type of psychosocial adversity and cumulative adversity with CVD risk factors. No specific type of psychosocial adversity was consistently associated with the CVD risk factors. There was evidence that a one standard deviation greater cumulative psychosocial adversity was associated with 0.51 cm greater waist circumference (95% confidence interval [CI]: 0.02 cm, 1.00 cm, p = 0.04) and a lower arterial distensibility, even after adjustment for age, ethnicity and childhood and adult socioeconomic position. We found no consistent evidence that any specific type of psychosocial adversity, or cumulative psychosocial adversity in childhood, is associated with CVD risk factors in adult women.     

疾病的道德化解读及其文化意义

中外医学史上存在着对疾病进行道德化解读的传统,疾病成为反映特殊时代和文化的价值与信仰的一种隐喻。在生物-心理-社会医学模式转型条件下,疾病的道德阐释获得了新的生长点,在敬畏生命、终极关照等层面上更加厚博、宏远,指向守护他人身心健康、守望自身精神家因的最终医学目的。社会文化背景下,疾病的道德解读,产生了深远的文化冲击,最为直接的就是指导从医者展开文化反思、拓展从医者生命伦理关注范畴、提供从医者人文关怀的维度,间接地启示从医者关注政治权利与医患的独特关系、主动担当推进历史进程的重任、认真思考哲学上的医患、审视医患文学的繁荣。     

浅谈学生群体冬季呼吸道传染疾病的预防

呼吸道传染疾病是冬季的多发疾病。大学生居住和学习环境相对集中,做好该类疾病的预防具有重要意义。本文针对呼吸道传染疾病的发生特点和有效可行的预防方法作了阐述。