慢性乙醇中毒患者EMG及NCV检测

目的观察电生理检测对慢性乙醇中毒的诊断价值。方法对32例慢性乙醇中毒患者的临床特征进行分析,并作神经电图（NCV）肌电图（EMG）检测进行分析。结果32例慢性乙醇中毒患者的EMG检查经综合判断提示神经源性损害;MCV异常率为65.6％,≥SCU异常率为83．3％．结论EMG,NCV能反映慢性乙醇中毒引起的周围神经系统的弥漫性损害,为临床提供电生理检测的客观指标。     

CFS的诊治及其运动处方的应用

查阅了近十几年的HIGHWIRE和MEDLINE上有关慢性疲劳综合症预后的文献,进行了系统的综述,介绍了慢性疲劳综合症(CFS)的诊断标准及病理机制,同时对各疗法效果进行了比较.结果表明,科学的制定运动处方,采用"阶梯运动疗法"能有效改善患者疲劳程度,减轻并发症状,提高运动能力.同时没有任何副作用.建议采用"阶梯运动疗法"治疗CFS,并对运动疗法处方的构成进行了归纳.     

Malnutrition-inflammation-atherosclerosis syndrome in Chronic Kidney disease

Chronic kidney disease is becoming a major health problem globally and in India an alarming number of about 8 million people are suffering from this disease. Patients undergoing hemodialysis have a high prevalence of protein-energy malnutrition and inflammation. As these two conditions often occur concomitantly in hemodialysis patients, they have been referred together as ‘malnutrition-inflammation-atherosclerosis syndrome’ to emphasize the important association with atherosclerotic cardiovascular disease. The three factors related to the pathophysiology in these patients are dialysis related nutrient loss, increased protein catabolism and hypoalbuminemia. Inflammation in Chronic Kidney disease is the most important factor in the genesis of several complications in renal disease. Pro-inflammatory cytokines like IL-1 and TNF-alpha play a major role in the onset of metabolic alterations in Chronic Kidney disease patients. Atherosclerosis is a very frequent complication in uremia due to the coexistence of hypertension, hyperhomocysteinemia, inflammation, malnutrition and increased oxidative stress, generation of advanced glycation end products, advanced oxidation protein products, hyperlipidemia and altered structural and functional ability of HDL. LDL-cholesterol, apolipoprotein (A), apolipoprotein (B), and Lp(a) are also associated with atherosclerosis. Studies have now provided enormous data to enable the evaluation of the severity of malnutrition-inflammation-atherosclerosis syndrome as well as effective monitoring of these patients.     

Oxidative stress and antioxidant status in patients with chronic myeloid leukemia

Chronic myeloid leukemia is a myeloproliferative disorder with a unique rearrangement, the Philadelphia chromosome. Oxidative stress, a pervasive condition of an increased number of reactive oxygen species, is now recognized to be prominent feature of various diseases and their progression. Thus antioxidants, which control the oxidative stress state, represent a major line of defense regulating overall true state of health. The relationship between antioxidants status and levels of well-known markers of oxidative stress that are measured as lipid peroxides and oxidized proteins reflect better health indices and postures. The aim of this study was to evaluate the role of oxidative stress in pathophysiology of Chronic myeloid leukemia by measuring the circulating plasma lipid peroxide levels in terms of malonyldialdehyde, total lipid hydroperoxide and oxidized proteins as protein carbonyl whereas antioxidant status were estimated in terms of reduced glutathione and total thiol in plasma of Chronic myeloid leukemia patients. The present study included 47 Chronic myeloid leukemia patients and 20 age-and sex-matched healthy subjects. Out of 47 Chronic myeloid leukemia patients, 31 were in chronic phase (CML-CP) and 16 in accelerated phase (CML-AP). The median age of Chronic myeloid leukemia patients was 33 years and that of controls was 32 years. Oxidative stress and antioxidant status in plasma were evaluated by spectrophotometric procedures. There was a significant increase (p<0.05) in plasma malonyldialdehyde, total lipid hydroperoxide and protein carbonyl levels in Chronic myeloid leukemia patients as compared to healthy subjects. Our results also showed that plasma malonyldialdehyde and protein carbonyl levels were markedly elevated (p<0.05) in both chronic phase (CML-CP) and accelerated phase (CML-AP) as compared to healthy volunteers. Antioxidant status was found to be significantly decreased (p<0.05) in Chronic myeloid leukemia patients and its phases as compared to healthy participants. It could be concluded that oxidative stress may be associated with the pathophysiology of Chronic myeloid leukemia.     

3种甘草酸苷对慢性乙肝患者血糖及肝功能病毒影响的临床研究

[目的]了解甘草酸苷对慢性乙肝患者血糖的影响.[方法]把95例确诊为慢性乙型肝炎的患者随机分为A、B、C三组,分别给予复方甘草酸苷80 m l、复方甘草酸单铵120 m l、甘草酸二铵40 m l静脉点滴,用药前、用药2周及4周观察三组患者的空腹血糖、肝功能、HBVM、HBV-DNA定量.[结果]治疗前三组患者空腹血糖的均数分别为5.28±1.75、5.32±1.66及5.65±1.82 mmol/L,在用药2周时,三组患者空腹血糖的均数即已有所下降,至用药4周其空腹血糖的均数分别为4.5 1±1.6 5、4.6 8±1.3 7及4.9 8±1.87 mmol/L,与治疗前相比三组患者空腹血糖的均数都有不同程度下降,但治疗前后的差异无显著性(P>0.05),各组之间下降的差异亦无显著性(P>0.05).[结论]甘草酸苷对慢性乙肝患者的血糖没有升高作用,反而在一定剂量下有降低的作用.     

δ-ALA levels in serum and urine—A diagnostic tool for possible lead poisoning

We present 2 cases of lead poisoning, the first of a child playing with painted toys and the second of an adult on local medicine. The former presented with acute abdomen and the latter with peripheral muscle weakness. We propose that raised serum δ-amino leavulinic acid (δ-ALA) levels strongly point towards the possibility of lead poisoning.     

慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机的舒适护理效果观察研究

目的:探讨慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机的临床护理方法及其疗效。方法:随机选择2012年1月~2014年2月广西中医药大学第一附属医院收治的100例慢性阻塞性肺疾病合并呼吸衰竭使用无创呼吸机进行治疗的患者,将所有患者随机分为研究组与对照组,每组50例患者。研究组患者给予舒适护理治疗,对照组患者给予常规护理治疗,分析两组的最终护理效果。结果:研究组患者在治疗积极配合率、并发症发生率以及不良情绪发生率上明显优于对照组,研究组患者的PaO2、PH与对照组对比,都明显高于对照组,PaCO2明显低于对照组,两组对比差异有统计学意义(P0.05)。结论:对慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机患者给予舒适护理治疗,可有效改善症状,提高临床疗效,值得推广。     

慢性乙型肝炎中医药治疗进展

慢性乙型肝炎（chronic hepatitis B,CHB）是临床的常见病、多发病,中医药在治疗慢性乙型肝炎有着丰富的临床经验。文章通过近几年来中医药在诊治慢性乙型肝炎的有关著作与文献资料的分析概括,阐述了慢性乙型肝炎的病因病机,辨证分型,专方专药治疗,总结了中医药的临床治疗近况。     

氨溴索治疗慢性支气管炎急性发作的疗效分析

目的：探讨氨溴索治疗慢性支气管炎急性发作的临床疗效及不良反应.方法：选取慢性支气管炎急性发作患者92例,随机分为对照组44例和观察组48例.对照组患者给予抗感染、祛痰、镇咳、平喘等常规治疗,观察组在对照组基础上加用盐酸氨溴索葡萄糖注射液滴注.结果：观察组临床控制率和总有效率均明显高于对照组（P＜0.05）,观察组平均住院天数明显少于对照组（P＜0.05）,两组均未出现明显不良反应.结论：氨溴索治疗慢性支气管炎急性发作临床疗效佳,且用药安全,可推广应用.