Chronic iliofemoral vein obstruction – an under-recognized cause of exercise limitation‡

Local symptoms of chronic venous insufficiency after deep vein thrombosis (DVT) are well described, but little is known about the effect of residual venous obstruction on exercise capacity. We tested our hypothesis that chronic residual iliofemoral vein occlusion (IFVO) after DVT may impair exercise capacity. Nine post-DVT patients with residual IFVO and effort intolerance were studied; a comparison cohort consisted of 11 healthy volunteers. Exercise tolerance was assessed by bimodality incremental symptom-limited cardiopulmonary testing, using leg and arm ergometers. In healthy subjects, leg vein obstruction was modelled by application to the thighs of cuff tourniquets inflated to 30–40?mmHg. Leg exercise tolerance as measured by oxygen uptake at peak exercise (peak ?’O₂) was reduced in patients (median 50% predicted (range 36–83%) vs. 88% predicted (67–129%) in normal subjects, p?2 was 0.95 (0.77–1.43) in patients vs. a normal ratio of 0.73 (0.6–1.0) in healthy subjects (p?2 in leg exercise to 76% predicted (range 55–108%; p?相似文献   

Urinary protein thiols in different grades of proteinuria

Total thiol status of plasma, especially thiol groups over protein contributes maximum to the plasma antioxidant status of the body. Serum protein thiols were found to be decreased in various disease conditions including chronic renal failure patients. Only few studies determined the levels of urinary protein thiols in disease conditions. The current study was designed to know the levels of urinary protein thiols in patients with different grades of proteinuria. The study was conducted on urine of 40 healthy controls and 61 cases with proteinuria. Based on proteinuria cases were further divided into two groups; group I - microproteinuria (150–300 mg protein/d), 32 cases, group II - frank proteinuria (>300 mg protein/d), 29 cases. Urinary thiol levels were determined by spectrophotometric method using dithionitrobenzoic acid. A significant decrease (p<0.01) in urinary thiol in group I and group II cases was observed in present study and this decrease was associated with proteinuria.     

Adverse childhood experiences,chronic diseases,and risky health behaviors in Saudi Arabian adults: A pilot study

Adverse childhood experiences (ACEs) have been linked with risky health behaviors and the development of chronic diseases in adulthood. This study examined associations between ACEs, chronic diseases, and risky behaviors in adults living in Riyadh, Saudi Arabia in 2012 using the ACE International Questionnaire (ACE-IQ). A cross-sectional design was used, and adults who were at least 18 years of age were eligible to participate. ACEs event scores were measured for neglect, household dysfunction, abuse (physical, sexual, and emotional), and peer and community violence. The ACE-IQ was supplemented with questions on risky health behaviors, chronic diseases, and mood. A total of 931 subjects completed the questionnaire (a completion rate of 88%); 57% of the sample was female, 90% was younger than 45 years, 86% had at least a college education, 80% were Saudi nationals, and 58% were married. One-third of the participants (32%) had been exposed to 4 or more ACEs, and 10%, 17%, and 23% had been exposed to 3, 2, or 1 ACEs respectively. Only 18% did not have an ACE. The prevalence of risky health behaviors ranged between 4% and 22%. The prevalence of self-reported chronic diseases ranged between 6% and 17%. Being exposed to 4 or more ACEs increased the risk of having chronic diseases by 2–11 fold, and increased risky health behaviors by 8–21 fold. The findings of this study will contribute to the planning and development of programs to prevent child maltreatment and to alleviate the burden of chronic diseases in adults.     

牙周炎与冠心病关系的META分析

目的:应用META分析技术定量评价慢性牙周炎与冠心病的联系。方法:检索中国期刊网、维普、万方数据等医学数据库,手工检索相关杂志并追查参考文献。独立筛选、评价文献和提取数据。对数据进行异质性检验后,借助Revm an4.2分析软件并根据其文献来源是否为同质总体而选择不同的M eta分析。结果:纳入6篇文献(794例病例)。冠心病组慢性牙周炎患病率为50.5%,而对照组仅为32.6%,两者差异有统计学意义(P<0.001)。单因素分析,慢性牙周炎与冠心病密切相关(OR=2.34,95%C I:1.16~4.73)。慢性牙周炎和冠心病不仅有统计学上的关联,还具有明显的剂量反应关系。结论:慢性牙周炎可能是冠心病的独立危险因素。     

Study of sEGF level in chronic atrophic gastritis with either Chinese traditional medicine or western medicine

This study was aimed to investigate the level of sEGF in CAG with different therapies of either Chinese traditional medicine or western medicine. Patients were divided into spleen-reinforcingⅠ, spleen-reinforcing Ⅱ,dampness-resolving and western medicine group by Differentiation Syndrome. Healthy volunteers acted as controls. The sEGF was investigated before and after treatment. The level of sEGF in CAG was higher than that in control group(P<0.01). In patients of spleen-reinforcingⅠgroup and spleen-reinforcing Ⅱgroup, the symptoms and pathological manifestations were improved dramatically (P<0.01) and sEGF dropped markedly after treatment(P<0.01 and P<0.05).The level of sEGF in the dampness-resolving group increased after treatment (P<0.05). But the level of sEGF in the western-medicine group dropped a little after treatment (P>0.05). The inflammation of gastric mucosa may cause the elevation of sEGF in CAG reflectively. After being effectively treated with Chinese traditional medicine, the symptoms of CAG improved simultaneously with the return of sEGF. SEGF is a sensitive index to prognosis of CAG.     

浅谈中医防治慢性前列腺炎

慢性前列腺炎中医属于＂淋证＂、＂尿浊＂等范畴。其病因主要为湿热下注。中医辨证分为湿热蕴结型、肝气郁滞型、瘀血阻滞型、脾肾阳虚型、肾阴亏虚型。外治法有针刺疗法、灸法、按摩法、坐浴疗法、中药煎汤保留灌肠。慢性前列腺炎应未病先防,中医辨证论治效果良好。     

真菌与慢性鼻窦炎伴鼻息肉发病的关系探讨

目的：探讨真菌与慢性鼻窦炎伴鼻息肉发病的关系。方法：回顾分析2005．1-2005．8月在我科住院48例慢性鼻窦炎伴鼻息肉患者的临床资料。结果：48例患者真菌过敏原皮试阳性9例；鼻分泌物涂片嗜酸细胞阳性31例，真菌阳性13例，鼻窦CT窦腔实变，呈云雾状或有散在钙化点6例，其中1例上颌窦腔扩大，窦壁骨质吸收；病理检查均证实鼻息肉诊断，真菌阳性6例，变应性真菌性粘蛋白阳性4例，组织内均无真菌侵袭。所有48例患者术后随访6个月以上，有效率为93．8％。结论：真菌是鼻窦炎鼻息肉的致病因素之一，术前确诊变应性真菌性鼻窦炎非常必要。     

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

The present study aims to assess and compare the biochemical oxidative stress markers in male smokers and non-smokers with chronic periodontitis. One hundred thirty-four male chronic periodontitis patients and 64 apparently healthy male volunteers were recruited for the study. The periodontal status was evaluated by measuring gingival index, plaque index, papillary bleeding index and clinical attachment loss using UNC-15 probe. The biochemical markers estimated were total antioxidant capacity, RBC-superoxide dismutase, glutathione peroxidase, vitamin C, malondialdehyde and C-reactive protein. The obtained results indicate higher oxidative stress in chronic periodontitis. Smokers with chronic periodontitis show significantly higher periodontal clinical parameters and relatively higher systemic oxidative stress. Vitamin C estimation may be an important biochemical parameter in conjunction with clinical parameters for diagnosis of chronic periodontitis in smokers.     

Combining physical and cognitive training to improve kindergarten children’s executive functions: A cluster randomized controlled trial

Considering the convincing evidence that executive functions predict academic achievement significantly, strategies to foster executive functions in the early school years are highly requested. Besides traditional cognitive training, combined physical and cognitive interventions are intended to be a feasible way of enhancing both children’s daily physical activity and executive functions. The purpose of the present study was therefore to test the effectiveness of a six-week combined physical-cognitive intervention, and to compare it to both a sedentary cognitive intervention and a waitlist control group. Using a between-subjects experimental design, 189 children aged between four and six years (M = 5.34, SD = 0.59) were recruited from 14 kindergarten classes, which were randomly assigned to one of three experimental conditions: (a) combined physical and cognitive training, (b) sedentary cognitive training or (c) waitlist control group. Before and after the interventions, all three core executive functions of updating, inhibition and shifting were measured. Physical activity was objectively measured using accelerometers during one intervention session. Linear mixed models revealed that children from both the combined physical-cognitive and the sedentary cognitive intervention improved their updating performance compared to the children of the control group. Inhibition and shifting remained unaffected by both interventions. With respect to children’s daily physical activity, linear mixed models showed that only the combined physical-cognitive intervention could significantly increase the amount of step counts. The results underline the feasibility of combined physical-cognitive interventions to enhance children’s daily physical activity and their cognitive performance.     

40例慢性鼻窦炎功能性鼻内窥镜手术治疗临床观察

目的观察应用功能性鼻内窥镜手术治疗慢性鼻窦炎的临床疗效。方法 2006年6月至2008年8月利用鼻内窥镜手术治疗慢性鼻窦炎40例。结果 40例患者中治愈28例,好转12例,效果满意。结论功能性鼻内窥镜手术微创,可视,手术边界清,减少损伤,彻底清除病变,疗效确切。今后应在功能性鼻内镜手术过程中向微创、无创精细程度上发展。