针灸治疗慢性踝关节扭伤145例疗效观察

145例患随机分成傍刺温针灸组83例和单一针刺组62例，治疗2个疗程，观察比较2组的疗效。结果显示：傍刺温针灸组的总有效率为98.8％，治愈率80．72％，单一针刺组为88．7％，51．61％，经统计检验，差异显或极显(P＜0．05，P＜0．01)。傍刺温针灸治疗该病的临床疗效优于单一针刺疗法。     

Communicating About Chronic Caregiving in the Workplace: Employees’ Disclosure Preferences,Intentions, and Behaviors

A growing number of Americans are living with chronic health conditions that require informal, ongoing care from family members who are also in the paid labor force. In this exploratory study, communication privacy management is used to make sense of chronic caregiving (N = 48–64) and noncaregiving (N = 174–178) employees’ disclosure preferences, intentions, and behaviors in the workplace. We find that workers in general anticipate that they would disclose to many individuals at work about their caregiving, but employees actually disclose much less information to far fewer people at work when they occupy the chronic caregiver role. For chronic caregivers, positive perceptions about coworker supportiveness predict increased disclosure behaviors. Finally, future research directions as employers, workers, and policy makers prepare for the complex challenges associated with negotiating paid work and unpaid chronic caregiving are provided.     

Off-pump coronary artery bypass grafting versus on-pump coronary artery bypass grafting: which is better in patients with chronic obstructive pulmonary disease?

To evaluate the clinic outcome of off-pump coronary bypass grafting (OPCABG) of patients with coronary heart disease and chronic obstructive pulmonary disease, we collected and analyzed 1998-2002 data on 28 patients with these two diseases who had received off-pump coronary bypass operation in our hospital, and compared with data on those who also had the same two diseases but received on-pump coronary artery bypass at same time. There were no operation-related death;one died of respiratory failure 14 days after operation while staying in hospital; there were more respiratory complications in the conventional coronary artery bypass grafting group (CCABG) than in the OPCABG group; and the PaO2/FiO2 in the CCABG group was higher than that in the OPCABG group during operation because of CPB, but lower than that in the OPCABG group 6-12 hours after operation. OPCABG seemed more suitable than CCABG for coronary artery disease patients with chronic obstructive pulmonary disease due to less damage to their oxygen-exchange capability and the fewer respiratory complications.     

双环醇治疗慢性乙型病毒性肝炎肝纤维化及其作用机制

[目的]观察双环醇对慢性乙型病毒性肝炎患者肝纤维化程度以及肝组织内转化生长因子β1(TGF-β1)和Ⅰ、Ⅲ型胶原含量的影响.[方法]20例慢性乙型病毒性肝炎患者以双环醇75~150 mg/d治疗24周,治疗前后分别肝活检进行常规病理学检查,并应用免疫组化技术和多媒体彩色病理图文分析系统观察双环醇治疗前后肝组织内TGF-β1和Ⅰ、Ⅲ型胶原含量的变化.[结果]慢性乙型病毒性肝炎肝纤维化患者经双环醇治疗后,肝组织炎症和纤维化程度明显改善,肝组织内TGF-β1和Ⅰ、Ⅲ型胶原含量均较治疗前明显降低,差异有显著性(P<0.05).[结论]双环醇治疗可以减轻慢性乙型病毒性肝炎患者肝脏炎症反应,同时明显降低慢性乙型病毒性肝炎患者肝组织内TGF-β1和Ⅰ、Ⅲ型胶原的含量,从而发挥抗纤维化作用.     

Effect of tadalafil in chronic renal failure rabbits: relevance to erectile dysfunction

It is of great importance to investigate an effective and reliable medication against chronic renal failure (CRF)-related erectile dysfunction (ED), which aims to improve patients’ life qualities. The concentrations of cyclic guanosine monophosphate (cGMP) in the corpus cavernosal smooth muscle of both CRF and control rabbits were measured. The effects of various concentrations of tadalafil, papaverine, and sodium nitroprusside on the relaxation responses of corpus cavernosal smooth muscle pre-contracted with phenylephrine in CRF rabbits were observed. There was significant difference in the concentration of cGMP between CRF and control rabbits (P<0.01). Tadalafil had the greatest impacts on CRF rabbits when given the same concentration of papaverine or sodium nitroprusside and particularly significant differences were identified under the concentration levels of 10⁻⁵ and 10⁻⁴ mol/L (P<0.01). The results suggest that the cGMP concentrations of the corpus cavernosum had been greatly reduced in CRF rabbits compared with control rabbits and that tadalafil may be an ideal medication for use in the treatment of CRF-related ED.     

Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model

Background and Objectives  

Chronic kidney disease (CKD) is a growing public health problem with an urgent need for new pharmacological agents. Cordyceps cicadae is widely used in traditional Chinese medicine (TCM) and has potential renoprotective benefits. The current study aimed to determine any scientific evidence to support its clinical use.     

柴芍六君子汤加味治疗慢性乙型病毒性肝炎的临床观察

目的:观察柴芍六君子汤加味治疗慢性乙型病毒性肝炎(肝郁脾虚型)的临床疗效。方法:将120例符合纳入标准的患者随机分为治疗组60例和对照组60例,对照组予恩替卡韦分散片治疗,治疗组在对照组基础上给予柴芍六君子汤加味治疗,治疗12周为1个疗程。结果:1个疗程结束后,治疗组总有效率为83.33%,对照组总有效率为60%,两组比较,治疗组优于对照组(P0.05)。结论:柴芍六君子汤加味联合恩替卡韦分散片治疗CHB疗效确切,值得推广。     

中医药保肝降酶治疗慢性乙型病毒性肝炎进展

慢性乙型肝炎患者,因HBV在体内不断复制,肝脏出现炎症坏死及其肝纤维化,导致病情进展、恶化,因此,对于ALT明显升高者或肝组织学明显炎症坏死者,在抗病毒治疗的基础上,当选用抗炎保肝药物尤其重要。中医药在慢性肝炎的保肝降酶治疗方面,积累了丰富的经验,提供了坚实的临床基础,文章从中医防治慢性乙型肝炎的理论基础、慢性乙型肝炎的辨证分型与肝功能的关系、中药复方及中药单体成分对慢性乙型肝炎的保肝降酶作用等方面,将近年来中医药对慢性乙型肝炎的保肝降酶的研究进行了综述。     

运动干预改善慢性肾病的研究进展

慢性肾脏疾病是复杂的威胁公共健康的疾病。慢性肾病与高致死率、高发病率、高治疗费用相关。肾脏纤维化是肾脏慢性病变的病理形态表现,是指在各种致病因子如炎性因子,机械性损伤,药物等导致的细胞外基质（extracellarmatrix。ECM）合成增多降解减少,肾小球基底膜增厚,最终影响肾脏功能。目前关于慢性肾病的研究重要集中在药物筛选方面,而运动是否能改善慢性肾脏疾病的研究较少。本文通过文献资料法与逻辑推理相结合的方法总结运动与慢性肾脏疾病的研究,总结指出：1适当的运动通过减弱肾脏病变引起的纤维化程度,改善慢性肾脏疾病。2运动可以通过调解TGF-β1／Smad信号通路改善慢性肾脏疾病