Effect of felodipine on the serum lipid profile of patients with hypertension

Forty patients suffering from mild to moderate degree of hypertension were put on felodipine. Their lipid profile was analysed before the start of their therapy and consecutively at two and four months after starting felodipine. There was a statistically significant fall in the levels of serum cholesterol, serum triglycerides and serum total lipids; though no appreciable variation was observed in HDL and LDL cholesterol levels. At baseline there were a few patients who had higher than the normal range of the serum lipid profile. Analysis of these patients showed a highly significant fall in the levels of serum cholesterol, serum triglycerides, serum LDL-cholesterol and serum total lipids i.e. felodipine modified the lipid profiles of hypertensive patients in a positive way.     

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Conditions like hypertension, atherosclerosis and diabetes are known to be the result of endothelial dysfunction which could begin early in the life of an individual. The markers of endothelial dysfunction studied in the present work are plasma hemoglobin, serum high sensitivity C-reactive protein (hsCRP) and plasma nitrite and nitrate. We studied the onset of endothelial dysfunction with increase in age as well as in disease condition like newly detected hypertensives and of hypertensive diabetic patients. The mean plasma hemoglobin and hsCRP values were found to increase with age. hsCRP and plasma hemoglobin levels were significantly higher in patient groups as compared to aged-matched controls. On the other hand nitrate and nitrite was significantly higher in patients who suffered from both diabetes and hypertension together and nitrate values were significantly lower in patients who suffered from hypertensive alone. Plasma hemoglobin and hsCRP are associated with endothelial dysfunction and increases both with age as well as in disease condition.     

我国高血压及冠心病患者的运动处方

对高血压和冠心病的概念、病因和运动对二者的作用等进行了讨论，对高血压及冠心病患者的特点，提出了一些有效的运动处方。     

高血压病患者动态血压与左心室舒张功能的关系

目的:探讨高血压病患者动态血压与左心室舒张功能的关系.方法:应用无创动态血压监测系统及彩色多普勒超声心动描记技术对76例老年高血压病患者(高血压组)和20例老年健康体检志愿者(对照组)进行检测,并对检测结果进行分析.结果:①高血压组患者发现有收缩功能不全者11例,占14.5%;舒张功能下降者41例,占53.9%; ②根据二尖瓣血流A峰速度(A)与E峰速度(E)的大小分组,A>E组患者的白天、夜间及24h平均收缩压均高于A相似文献   

健身气功·马王堆导引术锻炼改善高血压患者生存质量的实验研究

运用健身气功·马王堆导引术对高血压患者进行运动干预,能够达到以下效果：生理领域方面,改善患者的疲倦状态和睡眠质量,提高精力水平;心理领域方面,改善患者的心理健康,降低一定的消极思想,能够对他们的学习、记忆及注意力方面有所提高;社会关系领域方面,对患者练习来说简单易行,容易接受,同时能够改善人际关系,对积极降低血压有着十分重要的作用。     

内皮型一氧化氮合酶基因多态性与原发性高血压关系的研究进展

内皮型一氧化氮合酶(eNOS)是一氧化氮(NO)合成的限速酶,NO 是外周与中枢神经系统的神经递质,在心血管系统具有维持血管张力,调节血压等功能.一旦 eNOS 突变,NO 生成不足,即可引起高血压.文章对 eNOS 基因 G894T、T786C 和27 bpVNTR 的多态性与原发性高血压关系的研究进展作一综述.     

江苏省成年人肥胖与高血压的分布变化趋势

目的:了解江苏省成年人肥胖与高血压的关系及分布变化趋势,为肥胖与高血压的防治工作提供科学依据。方法:利用3次国民体质调查资料,分析高血压与肥胖的分布及关系;并建立江苏省国民体质监测GIS数据库,采用空间局部内插分析方法构建江苏省成年人高血压与肥胖空间分布的数字高程模型。结果:共调查85 371人,男性高血压患病率为21.4%,高于女性的14.1%(P<0.01)。农村成年人发生高血压的比例为21.5%,高于城镇的15.7%(P<0.01);高血压患病率随着年龄和体重指数的增加而上升(P<0.01)。肥胖是导致高血压的危险因素,且年龄越小,肥胖致高血压的风险越高。成年人肥胖导致高血压总的OR值为2.66(P<0.01),其中女性为2.42(P<0.01),男性为2.69(P<0.01)。高血压的空间分布图显示,2000年成年人高血压的高发地区主要聚集与江苏北部,在江苏南部同时存在着高血压患病率相对较高的区域。在随后的10年间,北部的高发区域已经逐步蔓延到江苏中部地区,而江苏南部高血压人群的范围虽然没有明显扩大,但是高血压患病率却有明显上升。肥胖的空间分布图显示,2000年江苏省成年人肥胖高发区域主要集中在北部地区,从北部向南部肥胖率逐渐下降,从西部向东部肥胖率也呈现下降趋势。但在随后的10年间,北部与中部两个高发区域范围进一步扩大,而且,有逐渐融合的趋势。结论:江苏省成年人肥胖与高血压的患病率存在空间分布差异,且两者的高发区域都在逐渐扩大,提示肥胖与高血压的防控形势不容乐观。     

动态心电图在高血压病中的临床价值

目的研究原发性高血压与心律失常的关系。费料与方法将襄樊市中心医院住院确诊为原发性高血压的80例患者进行24h动态心电图（DCG）检测,并把同期门诊诊治的高血压前期且伴有头晕心悸的31例患者作为对照组进行检测。结果高血压组DCG除2例外均有心律失常发生（98％）。结论：高血压患者进行动态心电图监测易发现心律失常。对高血压患者而言,在有效控制血压的基础上,防止左房左室扩大,改善心肌供血状况,是降低心律失常发生率的一个重要手段。     

Correlation between lipid peroxidation and non-enzymatic antioxidants in pregnancy induced hypertension

The present study was designed to evaluate the lipid peroxidation and non-enzymatic antioxidants in pregnancyinduced hypertension (PIH) compared with healthy normal pregnant and non-pregnant as controls. 75 cases were studied of which 25 were normal healthy controls (Group A), 25 healthy pregnant women (Group B) of third trimester and 25 were PIH (Group C) of the same trimester. In PIH, malondialdehyde a lipid peroxidation product was significantly increased as compared to normal pregnant and non-pregnant controls. The nonenzymatic antioxidants like reduced glutathione, Vitamin-E, Vitamin-C and Vitamin-A were significantly decreased in normal pregnants as compared to controls. A further significant decrease was noticed in PIH compared to normal pregnants. A significant negative correlation was detected between lipid peroxidation and non-enzymatic antioxidant levels. Our study clearly indicates a relationship between elevated lipid peroxidation, decreased non-enzymatic antioxidant in PIH. The measurement of non-enzymatic antioxidants in plasma may be useful predictor of the likely development of PIH.     

Tai Ji Quan as antihypertensive lifestyle therapy: A systematic review and meta-analysis

BackgroundProfessional health organizations are not currently recommending Tai Ji Quan alongside aerobic exercise to treat hypertension. We aimed to examine the efficacy of Tai Ji Quan as antihypertensive lifestyle therapy.MethodsTai Ji Quan interventions published in English and Chinese were included when they involved healthy adults, reported pre- and post-intervention blood pressure (BP), and had a non-exercise/non-diet control group. We systematically searched 11 electronic databases for studies published through July 31, 2018, yielding 31 qualifying controlled trials. We (1) evaluated the risk of bias and methodological study quality, (2) performed meta-regression analyses following random-effects assumptions, and (3) generated additive models representing the largest possible clinically relevant BP reductions.ResultsParticipants (n = 3223) were middle-aged (56.6 ± 15.1 years of age, mean ± SD) adults with prehypertension (systolic BP (SBP) = 136.9 ± 15.2 mmHg, diastolic BP (DBP) = 83.4 ± 8.7 mmHg). Tai Ji Quan was practiced 4.0 ± 1.4 sessions/week for 54.0 ± 10.6 min/session for 22.3 ± 20.2 weeks. Overall, Tai Ji Quan elicited significant reductions in SBP (–11.3 mmHg, 95%CI: –14.6 to –8.0; d₊ = –0.75) and DBP (–4.8 mmHg, 95%CI: –6.4 to –3.1; d₊ = –0.53) vs. control (p < 0.001). Controlling for publication bias among samples with hypertension, Tai Ji Quan trials published in English elicited SBP reductions of 10.4 mmHg and DBP reductions of 4.0 mmHg, which was half the magnitude of trials published in Chinese (SBP reductions of 18.6 mmHg and DBP reductions of 8.8 mmHg).ConclusionOur results indicate that Tai Ji Quan is a viable antihypertensive lifestyle therapy that produces clinically meaningful BP reductions (i.e., 10.4 mmHg and 4.0 mmHg of SBP and DBP reductions, respectively) among individuals with hypertension. Such magnitude of BP reductions can lower the incidence of cardiovascular disease by up to 40%.